Saratov JOURNAL of Medical and Scientific Research

immunotoxycity

Change in function of thl - and th2-lymphocytes and cytokine profile at chronic intoxication of ethanol

Year: 2010, volume 6 Issue: №2 Pages: 307-309
Heading: Anaesthesiology and Reanimatology Article type: Original article
Authors: A.A. Svistunov, P.F. Zabrodsky V.G. Lim, V.A. Grishin
Organization: Saratov State Medical University
Summary:

It has been established during the experiments carried on noninbred rats that chronic intoxication of ethanol (30 days, total dose - 6,0 LD50) essentially reduces concentration of cytokines (IFNy, IL-2, IL-4, IL-6,IL-10) in blood, reduces interrelation of IFNy/IL-4 in comparison with the control, suppresses immune reactions, indicating the greater lesion of Th1-cells in comparison with Th2-lymphocytes

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Activation of р-450-depended monooxygenases changing immunotoxicity of phosphoroorganic compounds due to their metabolism character

Year: 2010, volume 6 Issue: №1 Pages: 046-048
Heading: Physiology and Pathophysiology Article type: Original article
Authors: P.F. Zabrodsky, V.F. Kirichuk, V.G. Lim, I.Kh. Yafarova
Organization: Saratov State Medical University, Saratov Military Institute of Biological and Chemical Safety
Summary:

It was established that the application of the monooxygenase system inductors (MSI) of phenobarbital and benzonal up to acute poisoning of animals by trichlorfom in a dose of 1,0 LD50, metabolized in the organism till production of compounds with higher toxicity caused its immunotoxic properties increase. The experiment was carried out on outbred white rats. the acute dimethyldichlorvinylphosphate (1,0 LD50) poisoning, biotransformation of which proceeded with formation of less-toxic and non-toxic compounds after MSI introduction, caused its decrease of suppression influence on immunity system indices

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