Saratov JOURNAL of Medical and Scientific Research

Shuldyakov A.A.

Saratov State Medical University n.a. V.I. Razumovskiy, Head of Department of Infectious Diseases, Professor, Doctor of Medical Science

Neuroinfection in patient with HIV: case report

Year: 2018, volume 14 Issue: №1 Pages: 168-173
Heading: Neurology Article type: Case report
Authors: Sotskova V.A., Bachilo Е.М., Shuldyakov А.А., Kolokolov O.V., Barylnik Yu.B., Potemina L.P., Krajnova O.N.
Organization: Saratov Regional Centre for Disease Prevention and Control of AIDS
Summary:

Toxoplasmosis is one of the most common opportunistic infections in HIV-positive patients. The onset of HIV-infection with cerebral toxoplasmosis makes this disease a multidisciplinary problem and requires the participation of doctors of various specialties (infectious disease specialists, neurologists, neurosurgeons, general practitioners, etc.). Early diagnosis and treatment of this disease will reduce the risk of deaths and severe consequences. We carry out an analysis of the clinical case of toxoplasma encephalitis in a HIV-infected patient. We have identified errors in the establishing diagnosis. We have given a detailed account a patient management plan. We also comment on some of the problem early disease detection HIV-infection.

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Features of epi-demiological situation on HIV-infection in Saratov region

Year: 2017, volume 13 Issue: №3 Pages: 489-494
Heading: Infectious Diseases Article type: Original article
Authors: Sotskova V.A., Shuldyakov А.А., Kolokolov O.V., Abramyan T.L., Potemina L.P., Tsareva T.D., Perminova Т.А.
Organization: Saratov Regional Centre for Disease Prevention and Control of AIDS, Saratov State Medical University
Summary:

Objective: to perform analysis of HIV-infection epidemic in the Saratov region in the period from 1996 to 2015. Material and Methods. Epidemiological and static methods have been used, retrospective epidemiological analysis of HIV-infection progression on the territory of the region has been performed. Results. Excess incidence and prevalence of HIV-infection in the region has been noticed. The main virus routes are injections of narcotic drugs and sexual transmission. From 2009 the persons over 30 years old have been involved in the epidemical process to a greater extent. The increase in the number of women of fertile age among incident cases of HIV-infection has been registered. Increasing incidence rate of HIV-infection among rural people occurred. Conclusion. In the Saratov region, as well as in the Russian Federation, high burden of HIV-infection continues to persist, that imposes more detailed study of the problem.

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Rare forms neurological disorders in an HIV-infected patient

Year: 2016, volume 12 Issue: №2 Pages: 296-299
Heading: Neurology Article type: Case report
Authors: Sotskova V.A., Kolokolov O.V., Shuldyakov А.А., Makarov N.S.
Organization: Saratov State Medical University
Summary:

The study aims paying the attention of specialists in rare cases of pathology of the nervous system in HIV-infected patients. The clinical case of brain abscess in a 32 year-old HIV-positive patient. Against the background of the surgical and antiretroviral treatment of brain abscess in HIV-positive patients it managed to achieve a virologic response and regression of neurological symptoms. Presented clinical case can be useful for specialists in determining the tactics of treatment of brain abscess in HIV-infected patients.

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Depressive disorders development in connection with gut microflora and dietary factors

Year: 2016, volume 12 Issue: №2 Pages: 168-174
Heading: Psychiatry Article type: Review
Authors: Shuldyakov А.А., Barylni Y.B., Lyapina Е.Р., Ramazanova K.Kh., Filippova N.V.
Organization: Saratov State Medical University
Summary:

The morbidity of depressive disorders and their role in the formation of different human pathologies emphasize the actuality of searching for new approaches in the prophylaxis and treatment of depressions. The modification of gut microbiota may be a perspective direction of clinical investigation. Development in this area is based on the review of trials which confirm the significance of gut microflora composition in regulation of mental functions in particular mood and behavior as well as the role of diet in the development of depressions. The hypothesis of the role of gut microbiota in the development of depressive conditions was discussed.

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Formation of competency-based model in professional training of a doctor

Year: 2013, volume 9 Issue: №4 Pages: 754-756
Heading: Pedagogics and Education Article type: Short message
Authors: Romantzov M.G., Shuldyakov A.A., Melnikova I.Yu., Satarova S. A., Lisko O.B., Perminova T.A.
Organization: Saratov State Medical University, North-West State Medical University n.a. I.I. Mechnikov, Department of Neuropathology Assistant Professor, Candidate of Medical Science
Summary:

The shift in priorities in the system of Russian education, transition from reproductive learning to learner-centered approach, incorporation of competency-based approach into the educational standards of "the third generation" require the training of a competitive specialist with professional competency. Types of competencies are characterized. The competency presenting certain requirements is studied. The mastering of the requirements will enable to train qualified specialists. The quality of education directly influences the level of professional activity through the training of specialists and the development of sciences. Competence-oriented modules approach and adherence to pedagogic requirements in education enables the efficacy of professional training. Innovative techniques and approaches to organizing educational process in their active form stimulate the process of studying.

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Improvement of prophylax and treatment of acute respiratory viral infections

Summary:

The aim of the study is to estimate prophylactic and clinical efficacy of cycloferon concerning acute respiratory viral infection among military men in the period of formation of military units. Material and methods. 1300 military men were under observation in the period of formation of military units. There was calculated efficiency coefficient. Index of efficiency, and severity of disease, frequency of development and character of complications were established. Results. It is established that application of both prophylactic and clinical course of tablet of cycloferon in the period of seasonal increase of morbidity of acute respiratory viral infection in the period of formation of military units enables to increase significantly efficiency of prophylactic and clinical activities, to decrease morbidity, frequency of severe and complicated forms of disease. Conclusion. According to these results, the perspectives of cycloferon use in prophylaxis and treatment of acute respiratory viral infection in the closed units were worked out.

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New approaches to therapy of oral inflammatory diseases

Year: 2013, volume 9 Issue: №3 Pages: 467-469
Heading: Stomatology Article type: Original article
Authors: Soboleva L.A., Bulkina N.V., Shuldyakov A.A., Pospelov A.N.
Organization: Saratov State Medical University
Summary:

The purpose of the work is to prescribe combined treatment in order to determine the efficiency of cycloferon liniment. Materials and methods. 80 patients suffering from such inflammatory disease of parodentium as herpetic stomatitis and periodontitis have been examined and treated. Results. Cycloferon liniment used in the combined treatment of stomatitis and periodontitis reduces the infection load in gingival pockets, decreases local inflammation, normalizes immunity parameters, decreases endotoxemia and reduces relapse rates. Conclusion. Cycloferon liniment is an efficient medication restoring the parameters of local nonspecific immune response.

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Efficacy of cikloferon liniment in complex therapy of secondary herpes associated with psoriasis

Year: 2013, volume 9 Issue: №2 Pages: 197-200
Heading: Infectious Diseases Article type: Original article
Authors: Shuldyakov A.A., Barchatova Т.S, Lisko О.В., Satarova S.A., Perminova Т.A., Tsareva T.D.
Organization: Saratov State Medical University
Summary:

The aim of the study: Modification in the treatment of patients with herpes associated with psoriasis. Materials and methods: 30 patients were included in the study divided into two groups. In the 1st group the patients received standard treatment for herpes and two daily applications of cikloferon liniment for seven days. In the 2nd group the patients received only standard treatment for herpes. The patients were followed-up for six months. The study was open-label randomized. Results: The results obtained show that general infectious symptoms of herpes subsided considerably faster in the 1st group of patients treated with cikloferon liniment. The applications with the topical immunomodulator enhanced more dynamic disappearance of erosions. During the six months follow-up exacerbations of herpes were noted in 10% of patients in the 1st group and in 30% of patients in the second group. Cikloferon liniment was well tolerated and no side effects were noted. Conclusion: Cikloferon liniment used for the treatment of patients with herpes exacerbation associated with psoriasis contributes to more dynamic disappearance of infectious syndrome, enhances epithelization of herpetic erosions, and lowers the duration of erosions and local inflammation as well as the number of exacerbations in catamnesis.

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Improvement of complex therapy of patients with pathology of scrotal organs formed by chronic brucellosis infection

Year: 2013, volume 9 Issue: №2 Pages: 165-170
Heading: Infectious Diseases Article type: Original article
Authors: Glybochko Р. V., Evdokimov A.M., Liapina Е.Р., Shuldiakov A. A., Ponukalin A.N., Blyumberg В.I., Sedova L.N.
Organization: First Moscow State Medical University n.a. I.M. Sechenov, Saratov State Medical University
Summary:

The aim of the study is to improve the treatment of patients with male reproductive organs pathology, formed by chronic brucellosis infection. Material and methods: We have analyzed the dynamics of the clinical manifestations of diseases of the scrotal organs, data of physical and ultrasound studies, semen parameters, the quality of life in 22 patients with chronic brucellosis and the presence of orchitis / orchiepididymitis against conventional therapy (10 patients), and combined treatment with the inclusion of cycloferon (i/m, 2 injection rate from 5 (0.25g) with a break 10 days) — 12. Results: We have proved ability of cycloferon to reduce the severity of the inflammatory process in the testis and epididymis, with improving of spermatogenesis and the quality of life for patients. We have marked the reduction in the number of exacerbations of chronic orchitis / orchiepididymitis 2.4 times after the course of cycloferon, its good tolerability of patients, no side effects. Conclusion: Using these results, the presence of anti-inflammatory and immunomodulatory potencies, cycloferon can be recommended in treatment of inflammatory lesions of the scrotal organs in patients with chronic brucellosis.

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Effciency of HIV-infected patients detection in neurological hospitals of large industrial center

Year: 2012, volume 8 Issue: №2 Pages: 563-567
Heading: Neurology Article type: Short message
Authors: Shuldyakov A.A., Kolokolov O.V., Potemina L.P., Abramova T.P., Kolokolova A.M., Lukina E.V., Sholomov I.I., Be-lousov M.I., Gryaznеv R.А., Salina E.A., Ornatskaya N.А., Mysovskaya O.V., Shmelev V.V., Eystrakh V.A., Shumilova A.V., Sotskova V.A.
Organization: Clinical hospital n.a. S. R. Mirotvortsev SSMU, Clinical Hospital № 12, Saratov, Clinical Hospital № 9, Saratov, Saratov State Medical University
Summary:

Aim of the study: to evaluate the effciency of detection for HIV-infection in patients of neurological departments of Saratov. Materials and methods. We retrospectively analyzed 25 250 medical histories of patients hospitalized into neurological departments of Saratov hospitals between January 2007 and April 2012. Results. Blood samples of 2010 patients (7,96 %) were tested for the presence of HIV-antibodies. 37 patients were HIV-positive (1,84 % of examined patients and 0,15 % of the total number of patients). Conclusion. Increasing popularity and variety of clinical manifestations of HIV-infection requires the expansion of neurological patients whom serum test for antibodies against HIV is needed.

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