Saratov JOURNAL of Medical and Scientific Research

diabetes

Medical and social aspects of diabetes and diabetic retinopathy.

Year: 2017, volume 13 Issue: №3 Pages: 453-457
Heading: Health Service Organization Article type: Original article
Authors: Velichko Р.В., Osmanov Е.М., Manyakov R.R.
Organization: "Eye Microsurgery" n.a. academician S. N. Fedorov, Volgograd branch, Tambov State University n. a. G.R. Derzhavin
Summary:

The aim of the article: to study the medical and social aspects of diabetes mellitus and diabetic retinopathy at the regional level. Material and Methods. The prevalence, structure and dynamics of diabetes and diabetic retinopathy (DR) were analyzed among the population of the Tambov region for a seven-year period from 2010 to 2016 based on statistical compendiums on the main indicators of health facilities and the health of the population of the Tambov region (2010-2016) Russian statistical yearbooks (2010-2016), data from the regional State register of patients with diabetes. Results. In 2016 in the Tambov region, the prevalence of DR in type 1 diabetes is 53.2%, with type 2 diabetes 31.2%, significantly higher than all-Russian indicators, which were registered at 27.2% in patients with type 1 diabetes and 13.0% of patients with type 2 diabetes. Conclusion. The results of the comparative analysis of the level and structure of diabetes and DR indicate a negative trend among the population of the Tambov region, which dictates the need to develop effective and inexpensive methods for preventing the development and progression of DRs and making management decisions based on them.

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. Effect of the venous outflow ways from pancreatic transplant on carbohydrate metabolism after autotransplantation of pancreas in the experiment

Year: 2013, volume 9 Issue: №4 Pages: 951-954
Heading: Surgery Article type: Original article
Authors: Voskanyan S.E.., Degtyarev V.S., Korsakov I.N., Naydenov E.V., Artemiev A.I.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

The aims: to compare the state of carbohydrate metabolism in animals after pancreatectomy with autotransplantation of the pancreatic segment and with organization of the venous outflow in the inferior vena or portal vein. Material and methods. Proximal resection of the pancreas (group 1), pancreatectomy with autologous transplantation of the pancreas and with reconstruction of the venous outflow from the transplant into the inferior vena cava (group 2) and pancreatectomy with autologous transplantation of the pancreas and with reconstruction of the venous outflow from the transplant into the portal vein (group 3) were performed in 45 animals in the experiment. Examining the status of carbohydrate metabolism was performed by intravenous test for glucose tolerance. Results. Primary higher increase in glucose concentrations as compared to the values obtained at the intact animals and its slower decrease have been observed in animals after pancreatectomy with autotransplantation of the segment of the pancreas on iliac vessels (group 2), as well as on the mesenteric vessels (group 3). Higher blood glucose compared to animals subjected proximal pancreatectomy after 40 minutes after administration of glucose was detected in animals undergoing autotransplantation of the pancreas on iliac vessels (group 2) and in animals after autotransplantation of the pancreas on mesenteric vessels (group 3)— 11.82 (11,39-12,26) mmol/l and 10.65 (10,03-11,32) mmol/l, respectively. The glucose concentration in the blood plasma was lower in the animals of groups 2 and 3 below in comparison with the animals in group 1 to 120 minutes of the experiment. Significant differences in plasma glucose concentration between animals of groups 2 and 3 were not found. Conclusion. Significant effects of the ways of organization of the venous outflow from pancreatic transplant on the concentration of the glucose in the blood plasma by the carbohydrate load after pancreatectomy with autotransplantation of the pancreas were not found.

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Comparative assessment of efficacy of different methods of treatment of pancreatogenic diabetes mellitus in alcoholic and biliary forms of chronic pancreatitis

Year: 2012, volume 8 Issue: №3 Pages: 859-862
Heading: Endocrinology Article type: Original article
Authors: Kunitsyna М.А., Kashkina E.I.
Organization: Saratov State Medical University
Summary:

Aim: the study was devoted to the analysis of efficacy of different methods of treatment of pancreatogenic diabetes mellitus (DM) in alcoholic and biliary forms of chronic pancreatitis (CP). Material and methods. We have observed 86 patients with CP and first diagnosed DM. The assessment of carbohydrate metabolism compensation via HbA1 с level was done using analyzer IMX «Abbot» (USA). Results. At the 1st step of DM treatment we recommended the lifestyle modification and usage of creon 30-60.000 units daily. At the 2d step of treatment if necessary we added glyclazide. Conclusion. We have detected that irrespective of duration of alcoholic form of CP in case of subsequent DM development the lifestyle modification together with replacement ferment therapy in 90% of cases were non-effective. In the result of the research it was established, in case of 3 and more relapses per year in alcoholic form of CPthe probability of achievement of target HbA1 с level in complex with lifestyle changes and replacement ferment therapy was twice low, in connection with that fact the indication of oral anti-diabetic agents became necessary.

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Optimization of surgical treatment of diabetic foot syndrome in Saratov region

Year: 2012, volume 8 Issue: №1 Pages: 145-149
Heading: Surgery Article type: Original article
Authors: Osintsev E.Yu., Melsitov V.A.
Organization: Saratov State Medical University
Summary:

The research goal is to estimate the results of multidisciplinary approach to treatment of diabetic foot syndrome in the conditions of specialized hospital centre. Materials and methods: The clinical part of work is based on the study of surgical assistance range, recurrence of infectious complications of diabetes mellitus and mortality rate in 226 diabetic foot syndrome patients. Optimum results of treatment have been received in a group of patients with neuropathic forms of lower extremities damage. Conclusion: Use of multidisciplinary approach to the treatment of patients with complications of diabetes mellitus has improved survival rate (x2=12,1; p=0,002) and quality of life of patients with diabetic foot syndrome in Saratov region

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Features of clinical course and quality of life in patients with chronic pancreatitis and diabetes mellitus

Year: 2011, volume 7 Issue: №1 Pages: 087-091
Heading: Internal Diseases Article type: Original article
Authors: Kunitsyna М.А., Kashkina E.I.
Organization: Saratov State Medical University
Summary:

Clinical and life quality features of 183 patients with chronic pancreatitis and diabetes mellitus were studied. We have found that the incidence of exacerbations increased by 36,7% after the appearance of diabetes mellitus, the number of days of loss of ability to work increased by 27,8%, the quality of life decreased

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Hemopoiesis indices in patients with diabetes type II with and without vascular complications

Year: 2010, volume 6 Issue: №4 Pages: 783-786
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Bondar Т.Р., Anfinogenova O.I., Bondar M.V., Soldatov А.А.
Organization: Stavropol State Medical University
Summary:

The article presents data of 1470 case histories and laboratory findings of 290 patients with diabetes and 82 donors who have done such procedure for the first time. Changes of morphological and biophysical indices of erythrocytes, thrombocytes and leukocytes are determined. The analysis of laboratory findings among patients with diabetes complicated by vascular disorders, with diabetes without complications and healthy representatives of the investigation has been carried out. It has revealed significant changes in indices

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Immunological Indices At Gerontological Patients With Ischemic Heart Disease, Metabolic Disturbances And Osteoporosis

Summary:

Gerontological patients with ischemic heart disease which is not accompanied by such pathology as diabetes (SD) and osteoporosis (OP) with normal or increased body weight (females) generally have got «the highest potential of health». It has been proved by phase portraits and autoantibodies (AAb) and cytokines indices. Adaptative disturbances in these groups have been revealed at the age of 95 and 89 accordingly. The presence of such accompanying pathology as SD and OP causes dysadaptation. It is evident by means of autoantibodies (AAb) and cytokines indices and phase portraits of «temporary dependence of general cholesterol levels - its first derivative»

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