Saratov JOURNAL of Medical and Scientific Research

Gaydukova I.Z.

Saratov State Medical University n.a. V.I. Razumovskiy, Department of Hospital Therapy of Therapeutic Faculty, Post- graduate

Occurrence and features of uveitis in patients with rheumatic diseases: current peculiarities of clinical examination and patient management.

Year: 2017, volume 13 Issue: №2 Pages: 358-361
Heading: Ophtalmology Article type: Original article
Authors: Dzhalavyan Y.V., Kamenskikh T.G., Gamayunova K.A., Gaydukova I.Z.
Organization: Saratov State Medical University
Summary:

The objectives of the study are to establish the occurrence of uveitis in patients with rheumatic diseases, to assess the features of the uveitis in rheumatic disease in children and adults, and to analyze the effectiveness of theirtreatment. Materials and Methods. The study included 670 people with RH (stage I) and 35 patients who had uveitis and / or rheumatic fever who agreed to undergo additional ophthalmologic bleeding (stage II), including a standard ophthalmological examination including visiometry, biomicroscopy of the anterior segment, ophthalmoscopy of the posterior segment of the eye, refractometry, optical coherence tomography in angiomode(tomograph-angiograph CIRRUS HD-OCT MODEL 5000 (Carl Zeiss, Germany), dopplerography of the vessels of the eye. Results. The prevalence of uveitis in rheumatic diseases was established in 21%, which is higher than that in the general population. Uveitis in rheumatic diseases is recurrent and well-treated condition with frequent and complete improvement of visual acuity, and angiographycal features of uveitis, p <0,05 for all parameters. Conclusions. The high incidence of uveitis and relapsing their course in rheumatic diseases lead to necessity of an ophthalmologist's examination every 6 months. It is desirable to perform a comprehensive angiographic examination of uvea for the timely detection of erased and subclinical forms of uveitis.

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. Chronic kidney disease in patients with chronic back pain taking non-steroidal anti-inflammatory drugs

Year: 2016, volume 12 Issue: №1 Pages: 40-44
Heading: Internal Diseases Article type: Original article
Authors: Gaydukova I.Z., Rebrov А.Р., Lebedinskaya О.А., Polyanskaya O.L., Patrikeeva D.A., Aparkina A.V.
Organization: Saratov State Medical University
Summary:

The aim of the study was to evaluate the incidence of chronic kidney disease (CKD) in patients with chronic back pain and nonsteroidal anti-inflammatory drugs (NSAIDs) intake not less than a year, and to study the interrelation between CKD, peculiarities of pain and its treatment. Material and Methods. 91 patients with axial spondyloarthri-tis — ax-SpA(ankylosing spondylitis and non-radiographic ax-SpA) and 35 patients with degenerative diseases of the spine (DDS) with NSADs intake not less than 1 year were involved in the study. The control group included healthy volunteers who did not took NSAIDs during the last year (n=51). By age, gender, factors of cardiovascular risk, GFR
in patients with ax-SpA, DDS and controls were comparable. The activity of pain was evaluated according to the accepted recommendations. The index of NSAID intake as calculated for the preceding year. Results. GFR in patients with ax-SpAwas 87,0 [77,25; 102,0] ml/min/1,73 m2, 11 (18%) patients showed a reduction in GFR of less than 60 ml/ min/1,73m2. In patients with DDS GFR was 87,5 [65,5; 97,0] ml/min / 1,73 m 2 (p=0,27), decreased GFR of less than 60 ml/min / 1,73 m2 was detected in 3 (15%) patients. The ratio of albumin / creatinine urine in patients with ax-SpA was 35,8 [25,46; 43,4] mg/g, in patients DDS —207,1 [91,66; 244,59] mg/g (p

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Remote monitoring in patients with spondylitis

Year: 2014, volume 10 Issue: №2 Pages: 314-317
Heading: Proceedings of all-Russia week of science with international participants Article type: Original article
Authors: Akulova A.l., Gaydukova I.Z.
Organization: Saratov State Medical University
Summary:

Objective: to evaluate the adherence to therapy and treatment outcomes in patients with spondylitis (SpA) in which activity of the disease managed remotely. Material and Methods. 193 patients with axial SpA were randomized into 3 groups with the different ways of the disease activity monitoring: 96 patients were managed in free way, 26 patients visited rheumatologist every 12 weeks, 69 patients managed remotely — we called them every 4 weeks. After the first year of follow up we made 3-month break in the telephone monitoring. The data on the treatment and SpA activity (indexes BASDAI, PASS, ESR, CRP) were collected. Results. In patients managed in a free way SpA activity was severe after a year. In groups managed remotely and once in 3 month the significant reduction in the disease activity was achieved with maximal decrease in remote monitoring group. Positive PASS group 3 was found in 15 patients (57.69%, n=26), in group 2 — in 4 patients (20%, n=20), in group 1 — no patients (0%). NSAIDs intake was arbitrarily changed by 5 (19.23%, n=26), 15(75%, n=20), and 93(96.87%, n=96) patients of groups 3, 2 and 1, respectively. After a 3- month break in remote monitoring in 13 patients with initial BASDAI>4 disease activity significantly increased, in 33 patients with BASDAK4 disease activity decreased. 17 (51.5%) patients independently changed the drug intake regimen after the break in monitoring. Conclusion. Remote monitoring is associated with better adherence to therapy and the best results of treatment of patients with SpA than the other modes of observation. Remote monitoring frequency must be determined individually.

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Exrtraarticular manifestations of psoriatic arthritis in patients with low clinical and laboratory activity of disease

Year: 2011, volume 7 Issue: №1 Pages: 107-111
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Gaidukova I.Z., Kargalskaya O.G., Rebrov A.P.
Organization: Saratov State Medical University
Summary:

The research goal is to present the clinical observation that shows possibility of combination of low clinical and laboratory activity of psoriatic arthritis with 1) a large amount of exrtaarticular manifestations; 2) severe lesion of internal organs; 3) development of nephritis and hepatitis; 4) cardiovascular system pathology. The possibilities of different diagnostic and therapeutic methods have been considered in the article

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Peculiarities of dyslipidemia in patients with psoriatic arthritis: connection with atherosclerosis, cardiovascular risk factors and inflammation activity

Year: 2010, volume 6 Issue: №3 Pages: 592-596
Heading: Internal Diseases Article type: Original article
Authors: Rebrov A.P., Gaydukova I.Z.
Organization: Saratov State Medical University, Saratov Regional Clinical Hospital
Summary:

Objective: to found the dyslipidemia in patients with psoriatic arthritis and to study the connection between dyslipidemia and cardiovascular risk factors, atherosclerosis and inflammation activity. 40 persons with PsA without cardiovascular diseases were involved in the study, 25 healthy people were examined like controls. Activity of PsA was learned by DAS, Likert index, Ritchie Arthicular Index, Number of swelling joints (NSJ), ESR, C-reactive protein (CRP) and fibrinogen. Total cholesterol, triglycerides, low and high density lipoprotein cholesterol, hypertension, body mass index, individual cardiac history were performed like cardiovascular risk markers. The ultrasound measuring the thickness of intima-media layer (IML) in carotid arteries was performed to subclinical atherosclerosis study. Increase of total cholesterol, triglycerides and low density lipoprotein cholesterol level was found in patients with PsA comparative with controls. There was prevalence of high and moderate increase of total cholesterol in patients with PsA, and in controls only low increase was measured. Correlation between total cholesterol and NSJ, fibrinogen, hypertension and IML was found. Low density lipoproteins were tingly interrelated with ESR, hypertension and IML. Very low density lipoproteins were connected with age of disease beginning, hypertension and IML, and triglycerides-with hypertension, enthesitis and dactilitis. Dyslipidemia in patients with PsA characterizes by total cholesterol, triglycerides, low density lipoprotein cholesterol increase, but not high density lipoprotein decrease. There is the connection between dyslipidemia in PsA and inflammation activity, arterial hypertension and IML

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Endothelium Damage And Arterial Rigidity In Patients With Psoriatic Arthritis

Year: 2009, volume 5 Issue: №4 Pages: 544-548
Heading: Internal Diseases Article type: Original article
Authors: А.Р. Rebrov, I.Z. Gaydukova
Organization: Saratov State Medical University
Summary:

The research goal is to study the connection between activity of systemic inflammation, endothelium damage and arterial rigidity in patients with psoriatic arthritis (PsA). Expression of arterial damage (the level of circulation of endothe-liocytes (CEC)) and indices of arterial rigidity have been studied in 32 patients with PsA. Methods used in the investigation are oscillography, photopletismography and occlusion test. Control group consisted of 22 practically in good health state volunteers. Patients with PsA had endothelium dysfunction, damage of endothelium and higher arterial rigidity. These findings were related to PsA activity and observed in patients with serious joint damage

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