Saratov JOURNAL of Medical and Scientific Research


A rare case of Loeffler endocarditis associated with eosinophilic granuloma-tosis with polyangiitis

Year: 2017, volume 13 Issue: №4 Pages: 823-828
Heading: Internal Diseases Article type: Case report
Authors: Skryabina E.N., Safonova V.N., Agareva Т.А.
Organization: Saratov State Medical University

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare disease that affects small and medium-sized blood vessels of different organs, characterized by asthma, prominent peripheral blood eosinophilia. Cardiac involvement was reported in 20-50% and it is the major cause of mortality. A case of EGPA in a 43-year-old female, who had endocarditis, associated with thrombus formation in left ventricle, thromboembolic syndrome and recurrent stroke has been reported. The described case has showed that it is of crucial importance to perform the full cardiac imaging even in asymptomatic patients with suspected EGPA. The early identification of cardiac involvement may lead to better prognosis.

2017_04_823-828.pdf1.29 MB

Resonance radio wave diagnosis of localized sclerodermia: pilot study

Year: 2017, volume 13 Issue: №3 Pages: 585-590
Heading: Dermatovenerology Article type: Original article
Authors: Moiseev A.A., Utz SR.
Organization: Saratov State Medical University

The purpose of the research was to study the diagnostic possibilities of the use of the active radiometry method for localized scleroderma (LS), both for monitoring the results of therapy, and for a comprehensive assessment of the functional state of body tissues in the study area, as well as the possibility of determining new foci of the disease. Material and Methods. In a pilot study, patients were presented with different forms of lesions and their different localization, as well as with different disease activity. The method of resonance wave diagnostics is implemented in the diagnostic complex "Aquafon". Results. The primary registration of wave activity in different types of foci may differ. The activity of the foci and the possibility of the appearance of new foci can be said not so much by the data of the initial measurements as by the integral data on their difference before and after the illumination procedure, which requires further study. Conclusion. It is necessary to improve the measurement technique, avoid places where the sensor is not well attached to the skin or minimize this effect. The research also aimed to conduct studies with simultaneous use of other methods.

2017_03-1_585-590.pdf1.39 MB

Clinical and morphological features of diagnosis and treatment of various forms of primary hyperparathyorosis

Year: 2017, volume 13 Issue: №3 Pages: 541-543
Heading: Surgery Article type: Original article
Authors: Kovalenko Yu.V., Tolstokorov A.S., Kravchenya A.R., Khubolov A.M., Manakhov G.A.
Organization: Scientific Research Institute of Traumatology Orthopedics and Neurosurgery of Saratov State Medical University n.a. V.I. Razumovsky

Objective: optimization of the diagnostic algorithm and treatment methods for different clinical forms of the primary hyperparathyroidism. Material and Methods. The article presents the results of examination and operative treatment of 59 patients diagnosed with the primary hyperparathyroidism, such patients having symptoms specific for the disease or having no symptoms of the same. Results. We have not revealed intraoperative complications after surgical interference; laboratory findings have been normalized in 96.6% of cases. The patients having undergone the surgery have been followed up for 12 months with no relapse. 11.9% of the patients have been diagnosed with the asymptomatic primary hyperparathyroidism. Conclusions. Parathyroidectomy is the only radical and effective treatment for the primary hyperparathyroidism. Parathyroidectomy performed surgically to the proper extent, prevents the relapse as well as development of diseases resulting from the primary hyperparathyroidism.

2017_03_541-543.pdf276.83 KB

Revisiting of etiology, clinical picture and diagnosis of the Kleine-Levin syndrome.

Year: 2017, volume 13 Issue: №1 Pages: 181-187
Heading: Neurology Article type: Case report
Authors: Ulyanova О.V., Kutashov V.A.
Organization: Voronezh State Medical Academy

Objective: to draw the attention to the Kleine - Levin syndrome (SKL), a rare, poorly understood disease, not only in Russia but throughout the world. We analyzed the case of the 23-year old patient M, with the Kleine — Levin syndrome. SKL belongs to the group of recurrent hypersomnia and is characterized by long bouts of sleep lasting an average of 10-14 days, beginning with the imperative and difficulty awakening. During bouts of sleep observed unusual behavior of patients: hyperphagia; hypersexuality in males; irritability, restlessness, impaired mental activity; aggression; feeling of unreality of it all; confusion, hallucinatory episodes and depression in females. During wakefulness, marked dyspho-ria, emotional stupefaction, loss of memory. The syndrome develops in 4 times more often in men than in women, aged 12-25 years. Etiological factors: brain tumor, head trauma, metabolic disorders, acute infectious diseases with fever. Often the development of the syndrome is preceded by hyperemia and hypothalamic-pituitary dysfunction. The article discussed the etiology, diagnosis, and possible combinations of clinical manifestations in SKL.

2017_01-1_181-187.pdf276.47 KB

The modern view of the examination and treatment of patients with intracranial cystic formations

Year: 2017, volume 13 Issue: №1 Pages: 147-149
Heading: Neurology Article type: Author's opinion
Authors: Kolesov V.N., Lukina Е.М., Chekhonatsky А.А.
Organization: Saratov State Medical University

Objective: to determine the diagnostic and treatment policy (conservative and operative) in patients with intracranial cysts of various origins. We observed 116 patients with different brain cystic formations. Diagnostic tactics and principles of treatment were refined. The evaluation of treatment results was made.

2017_01-1_147-149.pdf220.99 KB

Innovation in diagnostics and treatment of epilepsy

Year: 2017, volume 13 Issue: №1 Pages: 143-147
Heading: Neurology Article type: Review
Authors: Kalinin V.A., Poverennova I.E., Yakunina A.V., Beketova E.M.
Organization: Samara State Medical University, Municipal Hospital No. 1 n.a. N. I. Pirogov, Samara

The aim of the review is try to systematize the innovative achievements of modern epileptology and indicate the levels of diagnosis and treatment of epilepsy that are not sufficiently developed, from our point of view. Applied to epileptology, the innovation process is realized at all levels. In principle, you can divide the entire process into a diagnostic and treatment level. Promising in the diagnosis of epilepsy should be considered the analysis of age characteristics, new methods of EEG analysis and evoked potentials, innovative methods of functional neuroimaging, genetic testing. New anticonvulsants with the original mechanism of action allow to overcome pharmaco-resistance of epilepsy in a number of observations. In rare cases it is necessary to use minimally invasive surgical methods of treatment.

2017_01-1_143-147.pdf242.49 KB

Modern methods of a localized scleroderma diagnostics

Year: 2016, volume 12 Issue: №3 Pages: 481-484
Heading: Dermatovenerology Article type: Review
Authors: Moiseyev А.А., Utz S.R.
Organization: Saratov State Medical University

Localized scleroderma (LS) is a disease that is characterized by the appearance of inflammatory, sclerotic and/or atrophic changes in the affected areas of the skin and underlying tissues. In ICD-10, the disease is considered under category L94 "Other localized connective tissue changes". This paper presents the classification of the disease developed for federal guideline 2015, for management of patients with localized scleroderma. Also, a brief description of the various methods of diagnosis of the disease, including laboratory tests, instrumental methods and disease severity scale are presented.
Keywords: scleroderma, diagnostics, dermatology.

2016_03-1_481-484.pdf245.31 KB

Diagnosis and combined treatment of patients with locally advanced prostate cancer

Year: 2015, volume 11 Issue: №3 Pages: 317-322
Heading: Urology Article type: Review
Authors: Popkov V.M., Kim T.D., Ponukalin A.N.
Organization: Saratov State Medical University

Prostate cancer is one of the most urgent problems of modern oncology. The article provides an overview of the methods of treatment of locally advanced prostate cancer, comparative characteristics, the advantages of both independent and combined methods. The results of multicenter studies have been stated.

2015_03_317-322.pdf298.2 KB

Modern strategy of diagnostics and treatment of NSAID-induced enteropathy in elderly

Year: 2015, volume 11 Issue: №1 Pages: 052-056
Heading: Gerontology and geriatrics Article type: Original article
Authors: Lipatova Т.Е., Dudaeva N.G.
Organization: Saratov State Medical University

The aim of the research is to improve the efficiency of diagnosis and treatment of NSAID-induced enteropathy at elderly patients with chronic pain (osteoarthritis, dorsopathy). Material and Methods. 300 elderly with osteoarthritis or dorsopathies regularly (8 weeks or more) receiving diclofenac at 75 mg per day were inspected. Clinical features, morphology, components of the diffuse endocrine system of the small intestine were studied. Results. It is defined, that at elderly patients with regular use of NSAIDs in 25% of cases postbulbar erosive duodenitis, in 75% of cases inflammatory and atrophic changes of the distal duodenum were diagnosed. Diagnosis of NSAID-induced enteropathy at elderly should include faecal calprotectin and morphology analysis of postbulbar area of the duodenum. Use meloxicam and sulfasalazine at older patients helps to eliminate or reduce intestinal dyspepsia, malabsorption, and intestinal inflammation on the results of faecal calprotectin and of histology of the small intestine. Conclusion. Elderly patients are at high-risk group for NSAID-induced enteropathy due to functional disturbances in the neuroendocrine system of the small intestine.

2015_01_052-056.pdf427.11 KB

Modern methods of early diagnostics of juvenile arthritis

Year: 2013, volume 9 Issue: №2 Pages: 308-313
Heading: Pediatrics Article type: Review
Authors: Chernenkov Y.V., Zakharova N.B., Kuzmina А.А., Spivakovsky Y.M.
Organization: Saratov State Medical University

The problem of inflammatory diseases of joints is one of the most important issues in the pediatrics. Nowadays the significant attention in this sphere is paid to the search of new accurate criteria of diagnostics. It will help estimate the severity of disease, determine the prognosis, choose the method of treatment and monitoring and evaluate the efficacy of the therapy.

2013-02_308-313.pdf279.99 KB