Saratov JOURNAL of Medical and Scientific Research

HIV infection

Clinical features of psoriasis in patients with chronic viral hepatitis and HIV infection

Year: 2018, volume 14 Issue: №4 Pages: 765-769
Heading: Dermatovenerology Article type: Case report
Authors: Tlish M.M., Kuznetsova T.G., Naatyzh Zh.Yu.
Organization: Kuban State Medical University
Summary:

Psoriasis is a chronic dermatosis which manifests itself as benign hyperproliferation of epithelial cells with disrupted differentiation and keratinization. In dermatology polymorbidity is quite widespread and relevant, but at the same time it is not sufficiently studied. Psoriasis in patients with HIV infection is often very severe and poorly amenable to standard methods of therapy, which makes study of clinical and immunological specifics of psoriasis natural history in such patients relevant. The disease significantly worsens quality of life, leads to disability and impairs social life of patients. The paper presents a clinical case in which altered clinical presentation and aggressiveness of psoriasis are related to comorbidities, which requires interdisciplinary therapeutic and diagnostic approach.

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Neuroinfection in patient with HIV: case report

Year: 2018, volume 14 Issue: №1 Pages: 168-173
Heading: Neurology Article type: Case report
Authors: Sotskova V.A., Bachilo Е.М., Shuldyakov А.А., Kolokolov O.V., Barylnik Yu.B., Potemina L.P., Krajnova O.N.
Organization: Saratov Regional Centre for Disease Prevention and Control of AIDS
Summary:

Toxoplasmosis is one of the most common opportunistic infections in HIV-positive patients. The onset of HIV-infection with cerebral toxoplasmosis makes this disease a multidisciplinary problem and requires the participation of doctors of various specialties (infectious disease specialists, neurologists, neurosurgeons, general practitioners, etc.). Early diagnosis and treatment of this disease will reduce the risk of deaths and severe consequences. We carry out an analysis of the clinical case of toxoplasma encephalitis in a HIV-infected patient. We have identified errors in the establishing diagnosis. We have given a detailed account a patient management plan. We also comment on some of the problem early disease detection HIV-infection.

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A clinical case of Stevens-Johnson syndrome in a patient with pustular psoriasis

Year: 2017, volume 13 Issue: №3 Pages: 646-648
Heading: Dermatovenerology Article type: Original article
Authors: Utz S.R., Bakulev A.L., Morrison A.V., Igonina I.A., Ardalina O.O.
Organization: Saratov State Medical University
Summary:

Saratov Journal of Medical Scientific Research 2017; 13 (3): 646-648. The article presents a clinical case of Stevens — Johnson syndrome and generalized pustular patient with HIV-infection. The characteristic of anamnestic, clinical, laboratory data is present. The cause of acute allergic reactions and the formation of severe dermatosis in a patient with HIV-infection are considered.

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Features of epi-demiological situation on HIV-infection in Saratov region

Year: 2017, volume 13 Issue: №3 Pages: 489-494
Heading: Infectious Diseases Article type: Original article
Authors: Sotskova V.A., Shuldyakov А.А., Kolokolov O.V., Abramyan T.L., Potemina L.P., Tsareva T.D., Perminova Т.А.
Organization: Saratov Regional Centre for Disease Prevention and Control of AIDS, Saratov State Medical University
Summary:

Objective: to perform analysis of HIV-infection epidemic in the Saratov region in the period from 1996 to 2015. Material and Methods. Epidemiological and static methods have been used, retrospective epidemiological analysis of HIV-infection progression on the territory of the region has been performed. Results. Excess incidence and prevalence of HIV-infection in the region has been noticed. The main virus routes are injections of narcotic drugs and sexual transmission. From 2009 the persons over 30 years old have been involved in the epidemical process to a greater extent. The increase in the number of women of fertile age among incident cases of HIV-infection has been registered. Increasing incidence rate of HIV-infection among rural people occurred. Conclusion. In the Saratov region, as well as in the Russian Federation, high burden of HIV-infection continues to persist, that imposes more detailed study of the problem.

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Comorbid diseases at patients with HIV-induced neurological disorders

Year: 2016, volume 12 Issue: №3 Pages: 388-390
Heading: Neurology Article type: Original article
Authors: Sholomova E.l., Rebrov К.А., Sholomov I.I.
Organization: Saratov City clinic №11, Saratov State Medical University
Summary:

Objective: to estimate the structure and frequency of detection of secondary diseases in patients with neurological manifestations of HIV infection. Materials and methods. The study involved 304 patients infected with HIV. Results. The defeat of the nervous system in HIV infection occur encephalopathy, cerebral vascular lesions, meningitis, subacute encephalitis, secondary CNS lesions. The number of CD4-lymphocytes in HIV-infected patients with neurological disorders was significantly lower. Most of them have comorbid diseases. The most commonly diagnosed hepatitis С and B, herpes, cytomegalovirus infection, chlamydia, Candida, toxoplasmosis and tuberculosis, mixed infection. Hepatitis В and С and herpes are the most widely represented in patients with HIV-induced encephalopathy and cerebrovascular form of HIV. The presence of cytomegalovirus infection is correlated with the development of subacute encephalitis. Conclusion. Manifestations of nervous system pathology in HIV polymorphic and correlated with the presence of secondary comorbid pathology. Such conditions are due to underlying disease immunological parameters.

Rare forms neurological disorders in an HIV-infected patient

Year: 2016, volume 12 Issue: №2 Pages: 296-299
Heading: Neurology Article type: Case report
Authors: Sotskova V.A., Kolokolov O.V., Shuldyakov А.А., Makarov N.S.
Organization: Saratov State Medical University
Summary:

The study aims paying the attention of specialists in rare cases of pathology of the nervous system in HIV-infected patients. The clinical case of brain abscess in a 32 year-old HIV-positive patient. Against the background of the surgical and antiretroviral treatment of brain abscess in HIV-positive patients it managed to achieve a virologic response and regression of neurological symptoms. Presented clinical case can be useful for specialists in determining the tactics of treatment of brain abscess in HIV-infected patients.

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Assesment of mineral metabolism in patients with HIV-infection, chronic hepatitis с and co-infection HIV/ chronic hepatitis С

Year: 2014, volume 10 Issue: №4 Pages: 617-622
Heading: Infectious Diseases Article type: Original article
Authors: Yurko Е.М.
Organization: Kharkov National Medical University
Summary:

Research Objective: Evaluate the indicators of mineral metabolism in HIV-infected patients, patients with chronic hepatitis С and co-infection HIV/HCV. Material and Methods: The content of microelements (zinc (Zn), copper (Cu), iron (Fe)) in serum was determined by atomic absorption spectrophotometry. The study involved 99 patients: with chronic hepatitis С — 32 patients, with HIV infection — 34 and co-infection of HIV/HCV — 33 patients. Results: Microelements and metal-dependent proteins metabolic disorders as a reduction of the zinc, haptoglobin contents, and an increase of copper, iron, and ceruloplasmin contents were identified in patients with chronic hepatitis С In HIV-infected patients and patients with co-infection HIV/HCV were identified reducing zinc, copper, iron, haptoglobin, ceruloplasmin. in patients with co-infection HIV/HCV compared HIV-infected patients lower zinc, haptoglobin, ceruloplasmin contents (p

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The characteristics of personality profile of patients with HIV-associated psoriasis

Year: 2013, volume 9 Issue: №3 Pages: 552-556
Heading: Dermatovenerology Article type: Original article
Authors: Morrison А.V., Utz S.R., Davydova А.V., Grishina V.B., Platonova A.N., Shtoda U.M.
Organization: Saratov State Medical University
Summary:

The goal: to give a characteristic of the personality profile, a comparative evaluation of psychosomatic changes in patients with psoriasis and HIV-associated psoriasis. Materials and methods. The study involved 27 patients aged
18-65 years with psoriasis and HIV-associated psoriasis, and isolated comorbid mental disorders and patients without skin disease, formed the control group. The survey in all patients was conducted with clinical-dermatological method, supplemented by psychometric methods (Hospital Anxiety and Depression Scale (HADS), the Hamilton Scale for Depression (HDRS)). Results. Analysis of the psychological status of patients with psoriasis demonstrated a high frequency of mental disorders in these patients.

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Microbial translocation and systemic inflammatory response in HIV-infection

Year: 2013, volume 9 Issue: №3 Pages: 508-512
Heading: Infectious Diseases Article type: Original article
Authors: Khasanova G.K., Bikkinina О.I., Anokhin V.A.
Organization: Kazan State Medical University
Summary:

The purpose of the research was detection of markers of systemic inflammatory response syndrome together with levels of markers of gram-negative endotoxinemia in HIV-patients for evaluation of role of endotoxin in immune system hyperactivation and progression of disease. Material and methods. Evaluation of levels of endotoxin, sCD14, interleu-kin 1(3, TNF-a and C-reactive protein was done in 232 HIV-positive patients. LAL-test, ELISA and biochemical tests were used. Results. The statistically significant increase of levels of all markers of systemic inflammatory response which were investigated was detected in the group of HIV-positive patients, comparing to group of healthy individuals. Direct correlation of sCD14 level with most of markers of systemic inflammatory response was found. Increased level of sCD14 was associated with more prominent clinical and laboratory signs of immunosupression. Conclusion. These results confirm a role of endotoxin which is a marker of microbial translocation and highly active biological substance in pathogenesis of immune system hyperactivation and progression of HIV-infection.

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Effciency of HIV-infected patients detection in neurological hospitals of large industrial center

Year: 2012, volume 8 Issue: №2 Pages: 563-567
Heading: Neurology Article type: Short message
Authors: Shuldyakov A.A., Kolokolov O.V., Potemina L.P., Abramova T.P., Kolokolova A.M., Lukina E.V., Sholomov I.I., Be-lousov M.I., Gryaznеv R.А., Salina E.A., Ornatskaya N.А., Mysovskaya O.V., Shmelev V.V., Eystrakh V.A., Shumilova A.V., Sotskova V.A.
Organization: Clinical hospital n.a. S. R. Mirotvortsev SSMU, Clinical Hospital № 12, Saratov, Clinical Hospital № 9, Saratov, Saratov State Medical University
Summary:

Aim of the study: to evaluate the effciency of detection for HIV-infection in patients of neurological departments of Saratov. Materials and methods. We retrospectively analyzed 25 250 medical histories of patients hospitalized into neurological departments of Saratov hospitals between January 2007 and April 2012. Results. Blood samples of 2010 patients (7,96 %) were tested for the presence of HIV-antibodies. 37 patients were HIV-positive (1,84 % of examined patients and 0,15 % of the total number of patients). Conclusion. Increasing popularity and variety of clinical manifestations of HIV-infection requires the expansion of neurological patients whom serum test for antibodies against HIV is needed.

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