Saratov JOURNAL of Medical and Scientific Research

optical coherent tomography

The far long-wave ultraviolet lichen planus therapy with the use of clearing agents

Year: 2017, volume 13 Issue: №3 Pages: 579-585
Heading: Dermatovenerology Article type: Original article
Authors: Artemina ЕМ, Utz SR, Zimnyakov DA, Slesarenko NA, Yuvchenko SA.
Organization: Saratov State Technical University n.a. Yu.A. Gagarin, Saratov State Medical University
Summary:

 The goal: to increase the effectiveness of far long-wave ultraviolet therapy in patients with lichen planus using immersion agents. Materials and Methods. The study included 50 patients aged from 18 to 65 years with typical and hypertrophic forms of lichen planus who had received UVA1-therapy. All the patients were divided into 2 groups: in the 1-st group before the phototherapy on the elements of lichen planus caused an clearing agent propylene glycol (PG) and in the 2nd group PG was not used. The dynamics of the enlightenment of the skin was assessed using optical coherence tomography. After the end of treatment was a decrease in mean group values of ILP 96% of the original value, pruritic index 98%, DLQI 87% respectively. Results. In the 1-st group patients occurred more rapid resolution of the pathological process, the rate of phototherapy was 15-20 procedures. In the 2nd group to complete resolution of the pathological process, required an increase in the number of procedures to 20-25. Conclusion. Far long-wave UV therapy showed high efficacy and compliance in patients with lichen planus, the use of the 1,2-PG allowed to shorten the duration of treatment of patients.

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Experience of antiangiogenic and corticosteroid therapy of a diabetic macular edema

Year: 2017, volume 13 Issue: №2 Pages: 383-388
Heading: Ophtalmology Article type: Original article
Authors: Kamenskikh T.G., Batishcheva Yu.S., Kolbenev I.O., Tsipyashchyk A.F., Andreychenko O.A., Gileva E.M., Vasil'yeva T.V., Zakharova N.B.
Organization: Saratov State Medical University
Summary:

Diabetic macular edema (DME) is a leading cause of blindness in patients with diabetes. The purpose of the research is to evaluate the effectiveness of treatment of patients with DMOs resistant to the administration of ranibi-zumab, using the intrauritreal implant "Ozurdex". Material and Methods. 66 patients (98 eyes) are examined. All of the patients were divided, into three groups, depending on a stage of a diabetic retinopathy. The patients underwent a complex of examinations: along with traditional methods, optical coherence tomography, fluorescence angiography of the fundus, multifocal electroretinography, determination of the content of VEGF-Aand cytokines in serum were used. Results. According to ОСТ of a retina and a visometry there are differences in efficiency of treatment depending on a condition balance of cytokine. Conclusion. The use of the intrauretic implant "Ozurdex" was more effective in patients with DMO in the stage of p re-pro I iterative diabetic retinopathy and in patients resistant to anti-VEGF therapy.

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Computer analysis of epiretinal membrane parameters

Year: 2017, volume 13 Issue: №2 Pages: 350-358
Heading: Ophtalmology Article type: Original article
Authors: Daurov S.K., Dolinina O.N., Kamenskikh T.G., Batischeva Yu.S., Kolbenev I.O., Andreychenko O.A., Potemkin S.A., Proskudin R.A.
Organization: Yuri Gagarin State Technical University of Saratov, Saratov State Medical University
Summary:

Objective: to develop algorithms of processing of video images of optical slices of the eye retina to quantify the degree of folding of the epiretinal membranes and of the central fossa. Material and methods. The object of the study was the video image of the retina obtained by optical coherence tomography. To develop methods of determining the degree of folding epiretinal membrane was formed mathematical model of the profile consisting of a base profile (low frequency component) and folding (high frequency part). Results. There had been developed two alternative methods of estimation of folding epiretinal membrane: retinal-averaging method and the method using the wavelet transform. The algorithm of geometrical parameters of the central fossa: the height, width and line shape. These algorithms are implemented in a software system. Conclusion. The practical application of the developed system showed its adequacy, as well as an introduction into medical practice the use of quantitative estimates of some parameters of the retina condition.

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Benefits of optical coherence tomography for imaging of skin diseases

Year: 2015, volume 11 Issue: №3 Pages: 392-396
Heading: Dermatovenerology Article type: Short message
Authors: Utz S.R., Zimnyakov D.A., Galkina E.M., Yuvchenko S.A., Alonova I.V., Artemina E.M., Ushakova O.V.
Organization: Saratov State Medical University, Saratov State Technical University n.a. Yu.A. Gagarin
Summary:

Aim: working out the methods of visualization of information obtained during optical coherent tomography in normal skin and in series of inflammatory disorders. Materials and Methods. OCS1300SS (made in Thorlabs, USA) was used in which the source of emission of radiation was a super-luminiscent diode with mean wavelength of 1325 nm. 12 patients with different skin conditions and 5 virtually healthy volunteers were examined with ОСТ procedure in OPD and IPD settings. High resolution USG numerical system DUB (TPM GmbH, Germany) was used for comparative USG assessment. Results. ОСТ demonstrated considerably more detailed picture of the objects scanned compared to USG investigation. Image obtained with the help of ОСТ contains vital information about sizes of macro-morphological elements, status of vascular elements and their density in different depths of the skin. Conclusion. Additional results obtained from ОСТ of the skin lesions in plane section improves attraction for ОСТ in practical dermatology.

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Analysis of the results of multifocal electroretinogram and optical coherence tomography in diagnosis and monitoring of patients with age-related macular degeneration

Year: 2014, volume 10 Issue: №2 Pages: 308-313
Heading: Proceedings of all-Russia week of science with international participants Article type: Original article
Authors: Ait Ahmed Кh., Kamenskikh T.G.
Organization: Saratov State Medical University
Summary:

Purpose: to study the correlation between the results of the macular area responses by multifocal-electroretinog-raphy (mf-ERG) and the retina thickness obtained by the spectralis optical coherence tomography (ОСТ) in patients with age-related macular degeneration (AMD). Material and methods. 28 patients (32 eyes) where enrolled in the main group. The control group was up to 10 patients without any AMD's pathological sign in retina. All patients were examined by the optical coherence tomography (ОСТ) and multifocal electroretinography (mf-ERG). Results. The data showed a high level of negative correlation between the retinal thickness and electrical amplitudes of the fovea. With the group of "dry" AMD the rise of the macular thickness (drusen) not over 290 urn showed a moderate reduction of the amplitude on mf-ERG The group with "wet" AMD showed that a higher rise of the retinal thickness (edema, fibrosis) of the macular zone negatively influences the bio-electrical activity of this area and this fact was confirmed by a considerable decline of the amplitude on the mf-ERG. Conclusion. The AMD's pathological changes that have been observed by ОСТ are objectively confirmed by mf-ERG. The mf-ERG in supplement of ОСТ can be used as an important element in the complex studies and objectively monitoring of patients with AMD.

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Optical coherence tomography of the epidermal sulfakrilate surface strippings

Year: 2013, volume 9 Issue: №3 Pages: 525-529
Heading: Dermatovenerology Article type: Original article
Authors: Utz S.R., Zimnyakov D.A., Galkina Е.М., Yuvchenko S.A., Reshetnikova Е.М., Alonova M.V.
Organization: Saratov State Medical University
Summary:

Method of the epidermal surface biopsy (ESB) with the adhesive compositions is the alter-native to the classic his-tological examination. Materials and Methods. In this study medical adhesive "Sulfacrylate" was used, small portions of which had been spread on an object glass, and then on different skin areas. To study the structural organization of the samples ESB the technique of optical coherence tomography (ОСТ) was used. Results. We obtained the pictures that visualize the structural organization of the different layers of the epidermis in lichen planus, hyperkeratosis, scabies and other skin diseases. Conclusion. This technique allows non-invasive measurement of high-precision structure of different layers of the epidermis, which can be useful both for research and for the practical dermatology.

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VISUAL DISTURBANCES IN PATIENTS WITH LATENT SYPHILIS

Year: 2012, volume 8 Issue: №2 Pages: 460-463
Heading: Neurology Article type: Short message
Authors: Kolbenev I.O., Kamenskih T.G., Kolokolov O.V., Bakulev A.L., Kolokolova A.M.
Organization: Saratov State Medical University
Summary:

Цель: определить характер зрительных нарушений у больных латентным сифилисом, оценить возможности исследования зрительных вызванных потенциалов (ЗВП), оптической когерентной томографии (ОКТ) и лазерной конфокальной томографии (ЛКТ) в диагностике и уточнении формы нейросифилиса. Материалиметоды. Обследованы 133 больных скрытым сифилисом на предмет выявления признаков поражения нервной системы и органа зрения. Результаты. Рутинное офтальмологическое обследование позволяет обнаружить нарушения зрения у 48 % больных латентным сифилисом. При нейросифилисе наиболее часто встречается ангиопатия сетчатки и первичная атрофия дисков зрительных нервов. Исследование ЗВП, использование ОКТ и ЛКТ позволяют выявлять признаки поражения органа зрения в 66 – 79 % случаев латентного сифилиса, нередко — до появления симптомов и признаков заболевания. Заключение. Офтальмологическое обследование должно быть обязательным не только при установленном диагнозе «нейросифилис», но и во всех случаях латентного сифилиса.

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Pathogenetic Aspects of Treatment of a Chronic Cystitis

Year: 2009, volume 5 Issue: №3 Pages: 424-428
Heading: Urology Article type: Original article
Authors: O.S. Streltsova, V.N. Krupin, E.V. Zagaynova, E.A. Tararova, V.V. Klochay, E.B. Kiseleva
Organization: N. Novgorod State Medical Academy
Summary:

The analysis of mucosa's state of the bladder in treating the exacerbation chronicle cystitis in 67 women was made. The analysis was made with the use of the method of optical coherent tomography (ОСТ). Dynamic ОСТ was performed in 23 patients after antibacterial treat (after 2 weeks) and in the period of remission. It was 59 ОСТ examinations. After antibacterial treatment the pathologically unchanged mucosa was found in the form of thickening in interu-retericfold in Lieutands triangle, in the neck of urinary bladder. Sub mucosal layer was also think, the structure of fibers was destroyed. Both leucocytic and lymphocytic infiltration in the wall of the bladder was observed. The tissue which reflected the light signal was found in muscle structure in the period of remission. This correspond to fibrosis in the wall of the bladder. In the long process the atrophy of mucosa was found. Thus, pathogenetic therapy should proceed after decrease in expressiveness of clinical displays of disease

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