Saratov JOURNAL of Medical and Scientific Research

Bashkir State Medical University of the Russian Health Care

Clinical significance of hyperglycemia in acute ischemic stroke

Year: 2018, volume 14 Issue: №2 Pages: 220-225
Heading: Neurology Article type: Original article
Authors: Izhbuldina G.l., Novikova L.B.
Organization: Bashkir State Medical University of the Russian Health Care, Ufa Clinical Hospital №18
Summary:

Aim: to study the effect of hyperglycemia on the course and clinical outcome of ischemic stroke (IS) in the acute period. Material and Methods. A total of 862 patients with IS (370 men, 492 women), mean age was 66.1±10.8 years. The degree of neurological deficit (NIHSS scale) and functional disorders (Rankin scale), clinical outcome were assessed. When admitted to hospital, a study of the level of glycemia on an empty stomach was conducted. Results. In 186 (21.6%) patients type 2 diabetes Mellitus (DM) was diagnosed. In 27.8% of patients without DM and 76.3% of patients with DM hyperglycemia was detected. In patients without DM with hyperglycemia, higher than in patients with normoglycemia, the representation of women (by 9.9%), cardioembolic stroke (by 10.5%), severe neurological deficit (by 14.7%), gross impairment of vital activity (by 14.0%), a decrease in the frequency of noticeable positive dynamics (by 14.8%), an increase in mortality (by 11.5%). In patients with DM, hyperglycemia was associated with a higher assessment rate on the Rankin scale of 4-5 points (by 25.6%) and a decrease in the incidence of noticeable positive dynamics (by 27.7%). Conclusion. Development of IS is characterized by high representation of disorders of carbohydrate metabolism (21,6%). The severity of glucose metabolism disorders is interrelated with the severity and clinical outcome of the disease.

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Clinical significance of hyperglycemia in acute ischemic stroke

Year: 2018, volume 14 Issue: №2 Pages: 220-225
Heading: Neurology Article type: Original article
Authors: Izhbuldina G.l., Novikova L.B.
Organization: Bashkir State Medical University of the Russian Health Care, Ufa Clinical Hospital №18
Summary:

Aim: to study the effect of hyperglycemia on the course and clinical outcome of ischemic stroke (IS) in the acute period. Material and Methods. A total of 862 patients with IS (370 men, 492 women), mean age was 66.1±10.8 years. The degree of neurological deficit (NIHSS scale) and functional disorders (Rankin scale), clinical outcome were assessed. When admitted to hospital, a study of the level of glycemia on an empty stomach was conducted. Results. In 186 (21.6%) patients type 2 diabetes Mellitus (DM) was diagnosed. In 27.8% of patients without DM and 76.3% of patients with DM hyperglycemia was detected. In patients without DM with hyperglycemia, higher than in patients with normoglycemia, the representation of women (by 9.9%), cardioembolic stroke (by 10.5%), severe neurological deficit (by 14.7%), gross impairment of vital activity (by 14.0%), a decrease in the frequency of noticeable positive dynamics (by 14.8%), an increase in mortality (by 11.5%). In patients with DM, hyperglycemia was associated with a higher assessment rate on the Rankin scale of 4-5 points (by 25.6%) and a decrease in the incidence of noticeable positive dynamics (by 27.7%). Conclusion. Development of IS is characterized by high representation of disorders of carbohydrate metabolism (21,6%). The severity of glucose metabolism disorders is interrelated with the severity and clinical outcome of the disease.

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Ohtahara II sydrome as a rare epileptic encephalopathy

Year: 2018, volume 14 Issue: №1 Pages: 123-126
Heading: Neurology Article type: Case report
Authors: Akhmadeeva L.R., Vashkevich A.G., Vorontsova L.M.
Organization: Bashkir State Medical University of the Russian Health Care, Ufa "Lege Artis" Clinic
Summary:

We present information about Ohtahara II syndrome which is a rare epileptic encephalopathy, and our own clinical
case: a 4-year old child with this disorder.

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Social and psychological components in rehabilitation medicine

Year: 2017, volume 13 Issue: №1 Pages: 127-131
Heading: Neurology Article type: Original article
Authors: Akhmadeeva L.R., Khokh I.R., Khusnitdinova S.R., Timirova A.F., Akhmadullin F.F., Akhmadeeva E.N.
Organization: Interdisciplinary Institute, Bashkir State Medical University of the Russian Health Care
Summary:

Aim: analysis of the current status and evaluation of the effectiveness of rehabilitation measures for patients with impaired motor function in the early recovery period of cerebral stroke in the conditions of a specialized inpatient department. Material and methods. The data of the state of patients with motor deficit after a cerebral stroke were analyzed in the rehabilitation department from November 2016 to March 2017. Results. During the study period, the effectiveness of the rehabilitation department for patients in the early recovery period of cerebral stroke was assessed. Improvements in cognitive functions were detected in these patients, and these patients also have a high potential for self-esteem of the social significance of the disease and the condition (anxiety and depression) at the time of being in the inpatient rehabilitation department. Conclusion. The presented data testify to the need to take into account the characteristics of patients in the early recovery period of cerebral stroke in the development of rehabilitation activities within the inpatient department.

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Objective assessment of postural function and falls prevention

Year: 2016, volume 12 Issue: №2 Pages: 250-253
Heading: Neurology Article type: Review
Authors: Akhmadeeva L.R., Kharisova Е.М.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

A literature review on evaluation of postural function in elderly patients is presented in the article. The detailed description of the main methods of diagnostics of balance disorders is given in the work.

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Comparison of key indicators of external respiration function in students of three health groups

Summary:

Purpose: to define key indicators of function of external breath of students of three groups of health taking into account various total sizes of a body. Material and Methods. For an assessment of breathing function, volume and highspeed characteristics the diagnosing Eton installations (Russia) and Schiller (Switzerland) were used. Results. Age peculiarities of respiratory ventilation disorders and differentiated assessment of circulatory and metabolic parameters according to the total body size in the special health groups (SHG) are analyzed in the article. Breathing volumetric characteristics were examined among the 17-18 aged students in the different health groups. Special attention is paid to the effect of the long-term severe bronchial patency disorders which lead to the respiratory muscles overstrain and the decrease of their strength endurance. This results in the lungs capacity decrease which is typical for the special health groups' students. Conclusion. It is shown that the students of the 1st health group had lower body weight and the same body length in comparison with the 2nd and 3rd groups. This determined unequal role of respiration in providing vital processes in terms of educational activities, especially in case of disorders of musculoskeletal and cardio-respiratory systems.

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Headache in pediatric practice: multifactor analysis of clinical and social predictors

Year: 2015, volume 11 Issue: №4 Pages: 548-551
Heading: Pediatrics Article type: Original article
Authors: Akhmadeeva L.R., Valeeva D.S., Veytsman B.A., Akhmadeeva E.N.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

The purpose of this work is to define the clinical and social predictors of headaches in children and adolescents. Material and Methods. We performed clinical examination of children and adolescents, which included studying their symptoms, anamnesis, somatic and neurological objective signs, survey using our original questionnaire and survey in the framework of an international project to study headaches «World Children and Adolescent Headache Project». The type of headache was diagnosed using international diagnostic criteria of the International Classification of Headache Disorders, 3rd edition (beta release). As a result of our study, we obtained the data about the most significant lifestyle factors (among those studied) influencing the number of days with headache per month, calculated linear coefficients and a predicting mathematical model for children. The sensitivity of the model for the prognosis of chronic tension type headache is 63%, specificity — 81 %. Conclusion. In this paper we describe criteria for the prognosis of primary headaches in patients aged from 8 to 18 years old.

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Clinical and immunological characteristics of hemorrhagic fever with renal syndrome in women of different age groups

Year: 2012, volume 8 Issue: №3 Pages: 765-769
Heading: Infectious Diseases Article type: Original article
Authors: Kutdusova A.M.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

Objective: To evaluate the clinical and immunological features of the hemorrhagic fever with renal syndrome in women of different age groups. Materials and methods: Clinical and laboratory characteristics of hemorrhagic fever with renal syndrome in 148 women aged 17 to 65 years old have been investigated. Patients have been divided into two groups: group I included 101 patients with normal menstrual rhythm, group II included 47 female patients with menopause. In 57 women (36 from group I, 21 — from group II) the content of CD3+, CD4+, CD8+, CD16+, CD19+ — sub-populations of peripheral blood lymphocytes has been determined. Results: In compared groups significant differences in structure and frequency of complications of the disease have been revealed. Unidirectional tendency to increase significantly reduced absolute rates of investigated lymphocyte subpopulations in dynamics of the disease has been identified. It also has been stated that by the time of early convalescence in case of severe form of HFRS the indices did not reach the standard level. In an older group of women deeper damage and long-term recovery of immune system have been marked. Conclusion: According to the results of clinical and immunological studies the research work has revealed that in young women the response of the immune system to HFRS has developed faster and stronger than that in patients during the menopause period.

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Dynamics of hormonal status in women of different age groups in hemorrhagic fever with renal syndrome

Year: 2012, volume 8 Issue: №2 Pages: 271-277
Heading: Infectious Diseases Article type: Original article
Authors: Kutdusova A.M., Murzabaeva R.Т.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

Objective: To study the hormonal parameters in women of different age groups in hemorrhagic fever with renal syndrome. Materials and methods: We have studied the content of cortisol, thyrotropic hormone (TTH), triiodothyro-nine (T3), free thyroxin (FT4), luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, estradiol, progesterone, prolactin in blood serum of 62 women with moderate (33) and severe (29) HFRS forms age (17-62). They were divided into 2 groups: the first group (33 patients) women with the normal menstrual cycle, the second group (29 women) consisted of patients in climacteric period. Results: TTH secretion increase, T3 and FT4 — decrease with their normalization to the recovery period were registered in the thyroid system of the compared groups. Blood cortisol level was high during the illness. Gonadotropic hypophysis function study demonstrated that LH and blood prolactin concentrations were increased since oliguria period; FSH was authentic reduced. The indices of these hormones were restored to the normal level by the reconvalescence period. LH and FSH contents were authentic higher in women of the second group in comparison with the first group. The hyperprolactinemia was observed in both women groups during the whole period of disease. The increased progesterone and testosterone concentrations have been manifested in blood serum. The estradiol concentration had different direction tendencies. Conclusion: Thus, the complex study of hypophysic- thyreoid and gonadotropic hormone state of adrenal system and the sexual hormone levels in women of different age groups in HFRS revealed the hormone status indces changes due to the period and severity of the disease, connected with the virus action, intoxication, the general inflammation reactions and their age.

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Analysis of polymorph genetic variations of angiotensin converting enzyme, glutathione S-transferase in patients with cardiomyopathy

Year: 2012, volume 8 Issue: №2 Pages: 224-228
Heading: Internal Diseases Article type: Original article
Authors: Berg A.R., Chepurnaya A.N., Karimov D.О., Viktorova T.V., Nikulicheva V.I., Safuanova G.Sh.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

Tropicality. Cardiomyopathies (CMP) are diseases of unknown etiology. CMP are usually diagnosed in late stages of the disease. The search for diagnostic methods for CMP in the early stage is of great importance. The purpose is to determine the character of distribution of polymorph genetic variations rates of angiotensin converting enzyme (ACE), glutathione S- transferase (GSTM 1) among CMP patients and healthy subjects living in the Republic of Bashkortostan and to substantiate their value in CMP pathogenesis. Materials and methods. A total of 67 patients with CMP were included in the study. Out of them, 40 patients were diagnosed with ischemic cardiomyopathy (ICMP) and 27 patients — dilatation cardiomyopathy (DCMP). 110 healthy persons were enrolled in the control group. Results. In the group of patients with ICMP, the genotype DD (x2=4,81; p=0,029) occurred more frequently. In DCMP group, there was also an increase in frequency of DD genotype of polymorph genetic locus of ACE gene (%2=4,046; p=0,044). Conclusion. Genetic analysis of polymorph l/D locus of ACE gene in patients with ICMP and DCMP showed a decrease in occurrence rates of II, ID genotypes, allele I, as well as an increase in DD genotypes and allele D. This is associated with an increased risk for the development of these cardiovascular diseases

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