Saratov JOURNAL of Medical and Scientific Research

Ulyanovsk State University

Pregnancy associated plasma protein-A in acute coronary pathology.

Year: 2014, volume 10 Issue: №1 Pages: 92-95
Heading: Сardiology Article type: Original article
Authors: Sapozhnikov A.N., Razin V.A., Chernysheva E.M., Gimaev R.Kh., Kajumova G.Kh., Mazurova O.V., Akhmetshina D.I.
Organization: Ulyanovsk State University
Summary:

The aim: to study pregnancy associated plasma protein A as a potential marker of myocardial necrosis with acute coronary syndrome. Material and methods. The rates of PPPP-A and insulin-like growth factor 1 were determined in 24 patients with acute myocardial infarction, in 18 patients with unstable angina and in the control group as well. Results. The rates of PPPP-A and ILGF-1 are accurately higher in the groups with acute coronary pathology in comparison to the patients with no ischemia. Conclusions. PPPP-A proves to be a marker of ischemia and/ or injury and could be used as a diagnostic predictor of an unstable atherosclerotic plaque in acute coronary development.

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The study of changes of biophysical properties of red blood cells in storage in erythrocyte-containing solutions using atomic force microscopy

Year: 2014, volume 10 Issue: №1 Pages: 44-48
Heading: Macro- and Micromorphology Article type: Original article
Authors: Lamzin I.M., Khayrullin R.М.
Organization: Ulyanovsk State University
Summary:

Currently the departments of quality control of blood centers evaluate the suitability for clinical use of erythrocyte-containing solutions indirectly by routine methods of the determination of hemoglobin concentration, hematocrit level, or hemolysis at the end of the period of storing. These methods can not directly characterize the state of membranes of preserved erythrocytes. The aim of the work is to study the changes of elasticity and surface potential of membranes of red blood cells of erythrocyte-containing solutions in storage for 35 days. Material and Methods. Two series of dry cytological preparations (smears) of erythrocytes have been investigated. The first group consisted of 8 samples of erythrocyte-containing solutions prepared on the day of preservation, and the second group included 20 samples prepared after the long term storage for 35 days at t=+4°C. Blood was stored in bags of «Baxter» company (USA) conserving with «CPDA-1». For atomic force microscopy five typical erythrocytes were selected and their elasticity was measured at 9 points of the membrane of each erythrocyte. Total number of measurements was 1296. Results. Average value of Young's modulus of the first group of samples was 1,81±0,02 (M±m) KPa. The second group showed 3,22±0,02 KPa statistically higher (p

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Antihypertensive therapy influence on clinical and psychological characteristics of patients with hypertensive encephalopathy

Year: 2011, volume 7 Issue: №4 Pages: 866-870
Heading: Neurology Article type: Original article
Authors: Belova LA., Gavrilyuk O.V., Mashin V.V., Belova N.V., Biktimirova K.T., Pinkova E.A.
Organization: Ulyanovsk State University
Summary:

Aim: to analyze the influence of antihypertensive therapy (AT) on clinical and psychological characteristics of patients with hypertensive encephalopathy (HE). Materials: 107 patients with HE l-lll were given inadequate AT and therefore were under the study. Diurnal blood pressure monitoring (DBPM), neurological status, asthenic disorder level, life quality (LQ) parameters, sleep quality and attitude-to-disease type were estimated. The patients were re-examined in 6-month period after prescribing an adequate AT. The control group included 30 healthy patients. Results: in the process of AT daily average indices of blood pressure (BP) were able to be matched with the control indices, the number of patients with normal degree of night BP decrease raised. Physical and psychological health constituents were increased. Sleep quality improved. The increase of patients with well-balanced attitude-to-disease type was fixed. Resume: the use of the modern antihypertensive drugs affects the clinical and psychological characteristics of HE patients positively

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Age aspects of inguinal hernia relapses

Year: 2011, volume 7 Issue: №1 Pages: 158-159
Heading: Surgery Article type: Short message
Authors: Ostrovsky V.K., Filimonchev I.E.
Organization: Ulyanovsk State University
Summary:

The research goal is to study an age role in relapses of inguinal hernias. Relapses of inguinal hernias in 113 patients have been investigated. It is established that the elder the patient the more frequent relapses of inguinal hernias occur. Causes of relapses of inguinal hernias development are age changes in the inguinal canal structure and the tissues that take place in its formation. The article concludes that causal factors of inguinal hernia relapses are age index and structure changes of inguinal canal. It points out that plasty of posterior wall of inguinal canal is considered as a preventive measure in case of inguinal hernia relapse

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Pharmacoeconomic analysis of ischemic stroke therapy in patients with arterial hypertension

Year: 2010, volume 6 Issue: №3 Pages: 579-582
Heading: Internal Diseases Article type: Original article
Authors: Mashin V.V., Barashkov N.S., Pinkova E.A., Khayrullin R.M.
Organization: Ulyanovsk State University
Summary:

Pharmacoeconomic parameters have been examined in patients with ischemic stroke who have suffered from arterial hypertension, depending on use of antihypertensive therapy. The role of antihypertensive therapy as a factor that significantly reduces the treatment costs and improves stroke outcome has been proved. The research results show the importance of integrated analysis of clinical and economical factors in the treatment of patients with arterial hypertension

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Directed administration of medicines in complex treatment of patients with biliary pancreatitis and нсv-infection

Year: 2010, volume 6 Issue: №1 Pages: 081-084
Heading: Internal Diseases Article type: Original article
Authors: Alexei L. Charyshkin, O.V. Midlenko, V.I. Midlenko, Alexandr L. Charyshkin
Organization: Ulyanovsk State University
Summary:

The research goal was to estimate efficiency of medicine phosphogliv by the directed administration in complex therapy for patients with biliary pancreatitis and НСV- infection. 62 patients with biliary pancreatitis and НСV-infection were examined. These patients were divided into 2 comparable groups: control group I (50 persons) and basic group II (12 persons). In group I traditional basic therapy of biliary pancreatitis was carried out with injection of phosphogliv intravenously. Patients of group II were given erythrocytes intravenously with average therapeutic dose of phosphogliv. Introduction of medicines in autologous erythrocytes was performed by hypotonic lysis.
Effective influence of directed administration of preparation phosphogliv demonstrated decrease in level of bilirubin in blood, activity of AlAt, AsAt in patients of research group. Side-effects were not revealed.
In conclusion the investigation proved that more effective influence of phosphogliv on level of bilirubin in blood and activity of AlAt, AsAt can be reached in combination with traditional basic therapy.

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БЛИЖАЙШИЕ РЕЗУЛЬТАТЫ ЛЕЧЕНИЯ БОЛЬНЫХ ЯЗВЕННОЙ БОЛЕЗНЬЮ ЖЕЛУДКА И ДВЕНАДЦАТИПЕРСТНОЙ КИШКИ, ОСЛОЖНЕННОЙ ПЕРФОРАЦИЕЙ (RUS)

Year: 2006, volume 2 Issue: №1 Pages: 30-35
Heading: Internal Diseases Article type: Original article
Authors: Midlenko V.I., Charyshkin A.L.
Organization: Ulyanovsk State University
Summary:

468 patients aged 14 to 88 years underwent surgery concerning perforative ulcer os stomach and duodenum. 10 patients had symptoms of stenosis including 10 patients with penetration. It is demonstrated that incision of ulcer with duodenoplasty or pyloduodenoplasty permit to treat successfully perforative ulcers and to achieve good functional results.

Keywords: ulcerous disease

COMPUTER-TOMOGRAPHICAL FEATURES OF CRANIOCEREBRAL TRAUMA WITH DIFFERENT GENESIS

Year: 2007, volume 3 Issue: №3 Pages: 73-75
Heading: Neurology Article type: Original article
Authors: M.V. Sagel, I.I. Sholomov, V.V. Mashin, R.K.
Organization: Ulyanovsk State University, Saratov State Medical University
Summary:

Analysis of the results of computer tomography (CT) of 247 patients with craniocerebral and mine-explosive trauma with different degree of damage in acute and distant period was provided. Authors revealed, that in acute period of craniocerebral trauma CT may detect different kinds of zones of concussion damage including bilateral damage. Atrophic process, mostly diffusive, may develop in distant period. Both ventricular system as well as subarachnoid space may be involved. Mostly severe atrophic cerebral changes are revealed due to third and fourth types of focal concussion damage of the brain. Mine-explosive damage of the brain is not visualized by CT-scanning in acute period. Generalized type of posttraumatic cerebral atrophy is revealed in patients with disease in distant period.

Keywords: traumatology
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Bilateral Variability of X-Ray Osteometric Parameters Of Human Metacarpal Bones

Year: 2009, volume 5 Issue: №3 Pages: 313-315
Heading: Macro- and Micromorphology Article type: Original article
Authors: А.S. Ermolenko, М. A. Ryakhovskiy, R.M. Khayrullin
Organization: Ulyanovsk State University
Summary:

Hand roentgenograms of men of mature age have been investigated. Parameters of metacarpal bones length and width of left and right hands have been measured. Displacement of maximal and minimal bilateral asymmetry on II and V rays of hand has been established. The obtained data have been considered from the point of view of fluctuating asymmetry, as an indicator of instability of morphogenesis which has been determined by HOX-genes defining structure of hand in mammals.

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CURATIVE AND DIAGNOSTIC TACTICS IN COMPLICATED FORMS OF GASTRODUODENAL ULCER DISEASE IN PATIENTS OVER 60

Year: 2008, volume 4 Issue: №2 Pages: 115-119
Heading: Surgery Article type: Original article
Authors: V.I. Midlenko, A.V.Smolkina, S.I. Barbashin
Organization: Ulyanovsk City Polyclinic № 7, Ulyanovsk State University
Summary:

The analysis of the treatment results of 319 patients with complicated forms of gastroduodenal ulcer disease has been carried out. The group is formed by the 223 patients over 60 years old and 96 young and middle-aged patients. The description ofpreoperative and postoperative treatmentwith application of the controlled sympathetic medication denervation of the elderly and aged people with complicated forms of gastroduodenal ulcer disease in the preoperative period and the exposure of the abdominal nerve plexus to alternative magnetic field of “Magniter" device have been provided. . The treatment algorithm of elderly and aged people with such pathology has been introduced. The results of the research have revealed reliable decrease in postoperative complications development incidence, postoperative complication development relief, earlier improvement of the clinical, laboratory and instrumental indices in elderly and aged patients with complicated forms of gastroduodenal ulcer disease, and also postoperative mortality decrease and cuts of the patients' stay period in hospital.

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