Saratov JOURNAL of Medical and Scientific Research

Khairullin R.M.

Ulyanovsk State University, Institute of Medicine, Ecology and Physical Culture, Head of Department of Normal and Pathological Anatomy, Professor, Doctor of Medical Science

The structure of thyroid gland in its pathology

Year: 2015, volume 11 Issue: №2 Pages: 113-117
Heading: Macro- and Micromorphology Article type: Original article
Authors: Khayrullin R.M., Kalmin O.V., Kalmin O.O.
Organization: Penza State University
Summary:

Objective: to identify the microscopic features of the structure of the thyroid gland in different forms of its pathology. Materials and Methods. The study is based on the thyroid glands of 199 patients of both sexes aged 21 to 74 years. Results. At the micro-macrofollicular nontoxic goiter was found flattened thyroid epithelium with flattened normochromic nucleus, the small size of cells and nuclei, low nuclear-cytoplasmic index, intrafollicular moderate epithelial proliferation, homogeneous colloid and moderate diffuse lymphoid infiltration. At the micro-macrofollicular toxic goiter detected cubic epithelium with rounded normochromic kernel, smallest size of cells and nuclei, nuclear-cytoplasmic minimum index intrafollicular focal proliferation of the epithelium, colloid mesh boundary with severe vacuolization, focal lymphoid infiltration and hemorrhage. When diffuse toxic goiter detected cubic form cells of medium size with a fairly high nuclear-cytoplasmic index, rounded normochromic kernel, rare intrafollicular epithelial proliferation, homogeneous colloid with an edge vacuolization. With the prevalence of autoimmune thyroiditis was observed flattened epithelium with rounded normochromic nucleus, the small size of cells and nuclei, found the average nuclear-cytoplasmic index, homogeneous colloid and extensive lymphoid infiltration with light propagation centers. Adenoma of the thyroid gland epithelium was found with a cubic cell shape, round hyperchromatic nucleus, the large size of cells and nuclei, high nuclear-cytoplasmic index intrafollicular diffuse proliferation of epithelial and dense colloid. When thyroid cancer found the prevalence of papillary structures with short broad papillae formed polymorphic cells with round hyperchromatic nucleus, there is the largest size of cells and nuclei, nuclear-cytoplasmic maximum index expressed intrafollicular diffuse proliferation of the epithelium. Conclusions. Each form of thyroid disease, along with well-known typical microscopic manifestations is a characteristic regional feature of the microstructure.

AttachmentSize
2015_02_113-117.pdf1.83 MB

The study of changes of biophysical properties of red blood cells in storage in erythrocyte-containing solutions using atomic force microscopy

Year: 2014, volume 10 Issue: №1 Pages: 44-48
Heading: Macro- and Micromorphology Article type: Original article
Authors: Lamzin I.M., Khayrullin R.М.
Organization: Ulyanovsk State University
Summary:

Currently the departments of quality control of blood centers evaluate the suitability for clinical use of erythrocyte-containing solutions indirectly by routine methods of the determination of hemoglobin concentration, hematocrit level, or hemolysis at the end of the period of storing. These methods can not directly characterize the state of membranes of preserved erythrocytes. The aim of the work is to study the changes of elasticity and surface potential of membranes of red blood cells of erythrocyte-containing solutions in storage for 35 days. Material and Methods. Two series of dry cytological preparations (smears) of erythrocytes have been investigated. The first group consisted of 8 samples of erythrocyte-containing solutions prepared on the day of preservation, and the second group included 20 samples prepared after the long term storage for 35 days at t=+4°C. Blood was stored in bags of «Baxter» company (USA) conserving with «CPDA-1». For atomic force microscopy five typical erythrocytes were selected and their elasticity was measured at 9 points of the membrane of each erythrocyte. Total number of measurements was 1296. Results. Average value of Young's modulus of the first group of samples was 1,81±0,02 (M±m) KPa. The second group showed 3,22±0,02 KPa statistically higher (p

AttachmentSize
2014_01_44-48.pdf1.12 MB

Pharmacoeconomic analysis of ischemic stroke therapy in patients with arterial hypertension

Year: 2010, volume 6 Issue: №3 Pages: 579-582
Heading: Internal Diseases Article type: Original article
Authors: Mashin V.V., Barashkov N.S., Pinkova E.A., Khayrullin R.M.
Organization: Ulyanovsk State University
Summary:

Pharmacoeconomic parameters have been examined in patients with ischemic stroke who have suffered from arterial hypertension, depending on use of antihypertensive therapy. The role of antihypertensive therapy as a factor that significantly reduces the treatment costs and improves stroke outcome has been proved. The research results show the importance of integrated analysis of clinical and economical factors in the treatment of patients with arterial hypertension

AttachmentSize
201003_579_582.pdf250.83 KB

Bilateral Variability of X-Ray Osteometric Parameters Of Human Metacarpal Bones

Year: 2009, volume 5 Issue: №3 Pages: 313-315
Heading: Macro- and Micromorphology Article type: Original article
Authors: А.S. Ermolenko, М. A. Ryakhovskiy, R.M. Khayrullin
Organization: Ulyanovsk State University
Summary:

Hand roentgenograms of men of mature age have been investigated. Parameters of metacarpal bones length and width of left and right hands have been measured. Displacement of maximal and minimal bilateral asymmetry on II and V rays of hand has been established. The obtained data have been considered from the point of view of fluctuating asymmetry, as an indicator of instability of morphogenesis which has been determined by HOX-genes defining structure of hand in mammals.

AttachmentSize
200903_313_315.pdf386.46 KB

PATHOGENETIC SIGNIFICANCE OF GROWTH FACTORS IN THE GESTOSIS DEVELOPMENT (CLINICAL RESEARCH)

Year: 2009, volume 5 Issue: №1 Pages: 51-54
Heading: Obstetrics and Gynecology Article type: Original article
Authors: L.U. Davidyan, E.N. Malanina, R.M. Khairullin, A.U. Bogdasarov, V.A. Selifonov
Organization: Ulyanovsk State University
Summary:

The decrease of epidermal and transformative growth factors in the process of gestation indicates the deficient development of fetopiacental complex and can be used as a prognosis criterion of the gestosis development from the beginning of pregnancy.

AttachmentSize
200901_051_054.pdf183.33 KB