Saratov JOURNAL of Medical and Scientific Research

Uljanov V.J.

Saratov State Medical University n.a. VI. Razumovsky, Scientific Research Institute of Traumatology Orthopedics and Neurosurgery, Deputy Director for Science and Innovations, Department of Innovative Technologies in Medical Care and Rehabilitation, Doctor of Medical Sciences

Characteristics of clinical findings and diagnostics of acute cerebral venous circulation disorder in immediate period following neurosurgical intervention for peripheral lung cancer metastasis into brain

Year: 2019, volume 15 Issue: №1 Pages: 67-71
Heading: Traumatology and Orthopedics Article type: Case report
Authors: Bazhanov S.P., Ulyanov V.Yu., Matveeva O.V., Tolkachev V.S., Shuvalov S.D.
Organization: Saratov State Medical University
Summary:

A rare case of cerebral venous circulation disorder in a female patient with peripheral cancer metastasis of the right lung upper lobe to the area of precentral and postcentral gyri of the left cerebrum hemisphere in the immediate post- surgical period is present. It has been shown that the diagnostics of impaired circulation throuth the superficial cerebral veins is rather complicated due to the lack of clinical symptoms specificity and poor sensitivity of neurovisualization methods.

AttachmentSize
2019_1_067-071.pdf541.49 KB

The history of the development of national traumatology on the example of medical and scientific activities of Saratov Research Institute of Traumatology and Orthopedics (SarNIITO) (1950-1980)

Year: 2018, volume 14 Issue: №3 Pages: 596-602
Heading: Traumatology and Orthopedics Article type: Short message
Authors: Ulyanov V.Yu., Grishin S.E., Puchinyan D.M., Fedonnikov A.S., Chibrikov G.l., Norkin I.A., Ilyina E.S., Skobelkina A.V.
Organization: Saratov Socio-Economic Institute of G. V. Plekhanov Russian University of Economics
Summary:

We outlined and described basic directions of national traumatology development at the period of 1950-1980 illustrated by the example of Saratov traumatological school, estimated the contribution of SarNIITO traumatologists into this development at the abovementioned period, depicted syna — one of the founders of acute trauma clinics.

AttachmentSize
2018_3-1_596-602.pdf1.01 MB

The epidemiology of spine and spinal cord injuries

Year: 2018, volume 14 Issue: №3 Pages: 592-595
Heading: Traumatology and Orthopedics Article type: Review
Authors: Tolkachev V.S., Bazhanov S.P., Ulyanov V.Yu., Fedonnikov A.S., Ninel V.G., Salikhu Kh., Norkin I.A.
Organization: Saratov State Medical University
Summary:

The article contains domestic and foreign data reflecting epidemiological peculiarities of traumatic injuries of spine and spinal cord, their character and incidence among various population groups with respect to gender and age parameters. The study outlines spine and spinal cord injury structure with regard to modern classification schemes, introduces injury incidence data, specifies indexes of lethality in spine and spinal cord injuries.

AttachmentSize
2018_3-1_592-595.pdf243.92 KB

Historical dynamics of social and role interaction between a doctor and a patient

Year: 2018, volume 14 Issue: №3 Pages: 549-552
Heading: Traumatology and Orthopedics Article type: Review
Authors: Katkova A.V., Andriyanova Е.А., Ulyanov V.Yu.
Organization: Saratov State Medical University
Summary:

The article presents social and role peculiarities of professional interaction in the system "doctor— patient" in the retrospective, various factors influencing the downfall in the social significance of doctor role at the present stage of medicine development from the point of view of a number of theoretical approaches. On the basis of literature review we outlined the necessity of medical sociological investigation for the study of professional practices in medical institutions with various social and role structure and indicated the importance of the development of medical and sociological tools for the assessment of interaction efficiency stipulated by the impact of social and role factor. was performed in the following databases: Web of Science, CyberLeninka, PubMed.

AttachmentSize
2018_3-1_549-552.pdf240.57 KB

Complex diagnostics and treatment potential of deep implant- associated infection of knee joint

Summary:

The review of open access literature on the issues of complex diagnostics and treatment potential of implant-associated infection of the knee joint area was given in the article. We describe clinical signs, the potential of laboratory diagnostics of deep implant-associated infection from the point of view of sensitivity and specificity as well as main methods of surgical treatment of the pathology.

AttachmentSize
2018_3-1_537-540.pdf291.83 KB

The role of skeletal tissue remodeling markers in the patho-genesis of implant-associated inflammation after primary knee arthroplasty

Year: 2018, volume 14 Issue: №3 Pages: 515-518
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Galashina Е.А., Bondarenko A.S., Ulyanov V.Yu., Klimov S.S.
Organization: Saratov State Medical University
Summary:

Aim: to reveal certain mechanisms of the pathogenesis of implant-associated inflammation by the level of resorption and bone tissue genesis markers in patients who underwent primary knee arthroplasty. Material and Methods. Main group consisted of 40 patients with implant-associated inflammation; first comparison group — of 20 patients with primary aseptic loosening of knee joint implant components; second comparison group — of 20 patients who underwent primary knee arthroplasty without complications in post-operative period; control group — of 20 conventionally healthy individuals. The levels of soluble receptor activator of nuclear factor kappa-B ligand and bone morphogenetic protein-2were defined in blood serum of all subjects by ELISA. Results. In patients of main group we observed more pronounced increase of soluble receptor activator of nuclear factor kappa-B ligand content and significant decrease of bone morphogenetic protein-2 content in blood serum; patients of first comparison group demonstrated activation of soluble receptor activator of nuclear factor kappa-B ligand and decreased levels of bone morphogenetic protein-2 in blood serum; patients of second comparison group did not demonstrate any changes in the studied indexes. Conclusion. The activation of soluble receptor activator of nuclear factor kappa-B ligand and decreased activity of bone morphogenetic protein-2 have leading role in the pathogenesis of implant-associated inflammation.

AttachmentSize
2018_3-1_515-518.pdf257.51 KB

Metabolic shifts in subjects with potential risk of primary osteoarthritis

Year: 2018, volume 14 Issue: №3 Pages: 511-514
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Belova S.V., Gladkova Е.М., Ulyanov V.Yu., Blinnikova V.V.
Organization:
Summary:

The Aim of the study was to estimate metabolic disorders in subjects with potential risk of primary knee osteoarthri-tis development. Material and Methods. The study included 27 patients: 10 men (37%), 17 women (63%) aged from 33 to 68 years, and 20 healthy people (8 men and 12 women). Traditional biochemical indexes characterizing certain metabolic aspects (total protein, urea, cholesterol, glucose, uric acid, amylase and bilirubin) were studied alongside with the assessment of articular cartilage state by the level of COMP (cartilage oligometric matrix protein), malondial-dehyde and ceruloplasmin. Results. In the course of our investigation we observed elevated COMP (Me=871,4 (792,2; 912,5)), malondialdehyde (Me=5,1 (4,7; 5,5)) and ceruloplasmin (Me=48,4 (41,2; 55,4)) levels. Conclusion. Negative metabolic shifts in the form of cartilage tissue metabolic disorders, activated lipid peroxidation and relative failure of body antioxidant system were observed in patients with potentially high risk of knee osteoarthritis without clinical manifestations of the disease.

AttachmentSize
2018_3-1_511-514.pdf239.29 KB

Long-term results of posterior anchorage of subaxial vertebra in acute unstable trauma

Year: 2018, volume 14 Issue: №3 Pages: 501-504
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Bazhanov S.P., Ulyanov V.Yu., Ostrovskiy V.V., Likhachev S.V.
Organization:
Summary:

Aim: to study long-term results of posterior anchorage of subaxial vertebra in acute trauma. Material and Methods. We conducted an analysis of long-term results of posterior anchorage of subaxial vertebra in 17 patients with acute unstable trauma which had undergone complex clinical neurological and instrumental investigation, surgical treatment performed from dorsal approach, and the estimation of long-term results in preoperative period. Results. The obtained data indicate the method of transarticular anchorage to be effective and safe and not to have any negative effect on biomechanical properties of cervical spine in the long-term postoperative period. Conclusion. The use of posterior anchorage in acute unstable trauma is most reasonable in subaxial injuries accompagnied by the deformities of medial and posterior spinal columns.

AttachmentSize
2018_3-1_501-504.pdf260.17 KB

The tactics of surgical treatment in metastatic lesions of upper cervical spine.

Year: 2018, volume 14 Issue: №3 Pages: 498-501
Heading: Traumatology and Orthopedics Article type: Case report
Authors: Bazhanov S.P., Gulyaev D.A., Ulyanov V.Yu., Ostrovskiy V.V., Tolkachev V.S.
Organization: The Almazov National Medical Research Centre, Head of Second Cerebral and Spinal Cord Tumors Department, Doctor of Medical Sciences
Summary:

We demonstrated a successful case of surgical treatment of the patient with metastatic lesion of upper cervical spine with respect to multidisciplinary approach. We performed simultaneous two-stage surgical intervention, the first stage being occipitospondylodesis by multi-segment construction; and second —tumor resection from expanded combined access. It has been stated that the proposed surgical tactics allows performing curative resection in one surgical session without neurological deficit buildup in the postoperative period.

AttachmentSize
2018_3-1_498-501_1.pdf1.09 MB

The role of microbial associations in the development of implant-associated infection after primary total knee replacement

Year: 2018, volume 14 Issue: №3 Pages: 492-497
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Babushkina I.V., Bondarenko A.S., Mamonova I.A., Shpinyak S.P., Ulyanov V.Yu.
Organization: Saratov State Medical University
Summary:

Aim: to study the role of microbial associations in the etiology of implant-associated infection, the peculiarities of associates antibiotic resistance, to propose informative methods for the microbiological diagnostics of mixed infections. Material and Methods. The biological samples from 488 patients with infectious complications after total knee replacement were studied. Microorganisms were isolated and identified using a BD BBL™ Crystal™ AutoReader analyzer and Crystal™ Enteric/ Nonfermenter ID Kit, Crystal™Gram-Positive ID Kit panels. Results. Polyetiological infectious complications comprise up to 21.4-24.8% out of the total number of implant-associated infection cases; microbial associations have broad microbial spectrum and various component structure. Specific gravity of clinically significant microorganisms — methicillin-resistant Staphylococcus aureus, polyresistant enterobacteria and nonfermentative Gram- negative bacteria is statistically higher (p<0.05) among the associates (38.2, 25.2, 64.3 and 72.8% respectively) than in monocultures (18.2, 11.8, 47.5 and 58.3% respectively). Microbiological methods should be modified in order to verify polyetiological implant-associated infection. Conclusion. The organization of microbiological monitoring of polyetiologi-cal implant-associated infections with detailed study of microbial associations structure, the monitoring of associates antibiotic resistance is necessary to optimize the diagnostics and causal treatment of this pathology.

AttachmentSize
2018_3-1_492-497.pdf372.67 KB