Saratov JOURNAL of Medical and Scientific Research

proliferation

Clinical and morphological characteristics of chronic duodenitis in children

Year: 2012, volume 8 Issue: №3 Pages: 799-803
Heading: Pediatrics Article type: Original article
Authors: Tishchenko D.V., Matveeva O.V., Chernenkov Yu.V., Maslyakova G.N., Bucharskaya A.B.
Organization: Saratov State Medical University, Engels City Polyclinic №3
Summary:

The research goal is to determine clinical, endoscopic and morphological signs of chronic duodenitis in children. Materials and methods: The diagnostic value of molecular markers has been revealed by immunohistochemical research of biopsy. It has been received from endoscopic examination of 32 children aged from 3 to 17 years old with chronic duodenitis. Morphometric investigation of markers expression has been carried out by means of analyzing system of digital images of Mikrovizor medical uVizo-103. Results: The index of proliferation has been higher in cells of cover epithelium than in glands. The inductor expression of apoptosis Bax has been poorly expressed in both groups of patients. It has been proved that proliferative processes are predominant in this pathology. Conclusion: It has been found out that proliferation of significant activity in the cover epithelium accompanies the development of preatrophic processes in children with chronic duodenitis. The greater degree of regeneration has been marked in crypts.

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Klinico-diagnostic value of indicators apoptosis and proliferation esofagogastroduode-nal zones at alcoholic liver disease

Year: 2009, volume 5 Issue: №3 Pages: 347-352
Heading: Internal Diseases Article type: Original article
Authors: Sushchenko M.A., Kozlova I.V.
Organization: Saratov State Medical University
Summary:

Purpose — Studying of kliniko-morphological features of a pathology of a gullet, stomach, duodenal gut and role of indicators apoptosis and proliferation in pathology development esofagogastroduodenal zones at alcoholic liver disease.
42 patients with an alcoholic hepatitis and 44 patients a cirrhosis are surveyed. By all it is spent endoscopic, histo-logic and immuno-histochemical inspection. By means of sets of antibodies studied proliferation activity epitheliocytes of stomach
At patients at transformation of a chronic alcoholic hepatitis in a cirrhosis accrue atrophy changes of a mucous membrane of a stomach, against against which chronic erosion or peptic ulcers without inflammations are marked. Processes proliferation and apoptosis are activated, that to the full defines morphological changes gastroduodenal zones
Strengthening of processes proliferation and apoptosis promotes progressing of structural changes esophagogas-tricduodenal zones that can serve additional diagnostic and prognostic as criterion.

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