Saratov JOURNAL of Medical and Scientific Research

Fedorov V.E.

Saratov State Medical University, Department of Faculty Surgery and Oncology, Professor, Doctor of Medical Science

Diagnostic value of bio-markers in the prognosis of postoperative relapses and metastases in patients with breast cancer

Year: 2017, volume 13 Issue: №2 Pages: 239-244
Heading: Oncology Article type: Original article
Authors: Cheburkayeva M.Yu., Zakharova N.B., Fedorov V.E., Teryoshkina N.E., Gergenreter Yu.S.
Organization: Regional Oncology center №2, Saratov State Medical University
Summary:

Purpose: to improve the diagnosis of relapse and metastasis of breast cancer in the postoperative period. Material and methods. 123 women were examined. Of these, 30 practically healthy women made up a control group, 20 women had benign breast diseases, 73 had breast cancer. The patients with ВС before the surgical intervention were divided into groups according to the stage of the disease. The 1st group consisted of 30 practically healthy women. In the second group — 20 women with fibroadenomas of the breast. In the third group — 33 women with l-ll stages of breast cancer without regional metastases. The 4th group consisted of 22 women with stage II breast cancer with regional metastases, in the 5th group — 18 patients with stage III breast cancer. After surgery, 68 patients were re-examined and divided into 2 analytical groups. The 6th group included women without clinical manifestations of relapses and metastases in the postoperative period — 44 (64.7%). Group 7 consisted of 24 (35.3%) women who had metastasis and local recurrences of the disease in the postoperative period. To determine the content of fetal proteins (Ca-15-3, Ca-125, REA), IL-8 and VEGF, commercial sets of reagents for solid-phase enzyme-linked immunosorbent assays were used. Results. Analysis of the data obtained showed that the most significant increase in serum and plasma VEGF levels occurred in breast cancer patients with clinical signs of metastasis and recurrence of the disease. Of fetal proteins, a significant increase in blood content showed Ca15-3 and CEA. Conclusion. We can assume that in patients with breast cancer only in the postoperative period, the rise in VEGF was associated with the growth of tumor tissue and the development of invasion and metastasis.

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Morphometric analysis of diffuse endocrine system's components in esoph-agogastroduodenal zone in different periods after cholecystectomy

Year: 2009, volume 5 Issue: №3 Pages: 342-347
Heading: Internal Diseases Article type: Original article
Authors: Graushkina E.V., Kozlova I.V., Fedorov V.E.
Organization: Saratov State Medical University
Summary:

The examination of morphofunctional features of esophagus, stomach, and duodenum as well as the role of diffusive endocrine system's cells in development of esophagogastroduodenal zone in patients without gallbladder is the purpose of the study.
80 patients with various periods after cholecystectomy and 72 patients with cholelithiasis were examined. Endo-scopic, histological and immuno-histochemical studies were carried out against all examined patients. The amount of epitheliocytes producing motilin (EC2), glucagon (L), and pancreatic polypeptide (PP) in duodenum were determined using antibodies sets. Esophagitis, atrophic- and reflux-gastritis, duodenal reflux are positively rather frequently met, atrophy and dysplasia of gastric mucous membrane increase in patients without gallbladder during the time after cholecystectomy. Hypoplasia of epithelial cells producing motilin, glucagon and pancreatic polipetide progresses. The development of duodenal and gastroesophagial reflux is associated with hypoplasia of epithelicytes producing motilin; the development of erosive changes is connected with hypoplasia of L and PP cells; the development of atrophic changes is closely related with hypoplasia of all studied cell types. The decrease of hormone producing epythelicytes promotes initiation and persistence of morphofunctional changes in esophagogastricduodenal zone. And this in turn can serve as additional diagnostic and prognostic criterion.

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