Saratov JOURNAL of Medical and Scientific Research

Khripunova G.I.

Saratov State Medical University, Head of Department of Obstetrics and Gynaecology of Pediatric Faculty, Professor, Doctor of Medical Science

Клинико-эпидемиологическая характеристика гриппа в постпандемический период

Year: 2013, volume 9 Issue: №2 Pages: 186-192
Heading: Infectious Diseases Article type: Original article
Authors: Maleev V.V., Mikhailova E.V., Chudakova Т.К., Romanovskaya A.M., Danilov A.N., Khripunova G.I., Dubovitskaya N.A.
Organization: Central Scientific Research Institute of Epidemiology, Saratov State Medical University
Summary:

Objective: To analyze the clinical and epidemiological characteristics in the post-pandemic influenza seasons in 2010/11/12/13 years. Material and methods: The analysis of the incidence of acute respiratory viral infections and flu in the Saratov region from 2009 to 2013. A clinical and laboratory examination of 252 patients with a diagnosis of «flu»: 152 pregnant women at different stages of pregnancy at the age of 18 years to 41 years and 100 children aged from 5 months to 14 years. The work was carried out to assess the epidemiological pattern and clinical course of influenza, and the effective operation of antiviral therapy. Results: In the post-pandemic period 2010-2013 simultaneously circulating influenza A viruses (N1N1/09) pd, influenza A (H3N2) and influenza B. In most cases, influenza in adults and children is of moderate form. All serious forms of influenza have been caused by influenza A with the development of viral-bacterial pneumonia, respiratory failure and neurotoxic syndrome. Late hospitalization and absence of antiviral therapy in the prehospital are at risk of severe and complicated forms. Conclusion: Early initiation of antiviral therapy is one of the main factors for the effectiveness of treatment and reduce the risk of influenza complications.

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Delivery in patients with hysteromyoma

Year: 2011, volume 7 Issue: №2 Pages: 401-403
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Khripunova G. I., Gurianiova N. S.
Organization: Saratov State Medical University
Summary:

Objective of the present article is to define optimal tactics and volume of surgical intervention in patients with hysteromyoma during labor process. Evaluation of possibilities and prospects of conservative methods of myomectomy have been determined. 1000 case histories dated 2009 were analyzed. Patients aged from 22 to 43 were under study. During the research it was revealed that hysteromyoma was mostly prevailed in women aged 30 and older (75%). 5% of them were primipara, 44% — bipara. 57% of pregnant patients were delivered by means of cesarean method. Widening of surgical intervention required 29% of 100 observed patients. Conservative myomectomy was conducted for 27 patients (87%), supracervical hysterectomy — for 2 women (6,4%). Natural delivery by vaginal route was marked in 43% of pregnant women with hysteromyoma; it was not a problem for birth and was first diagnosed in the early postnatal period by means of ultrasonic diagnostics. During analysis of the received data attention should be paid to expediency and promising of delivery of patients by means of cesarean method with following conservative myomectomy; it promotes to preserve childbearing function, their quality of life and consequently improves the demographic situation

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THE OPPORTUNITIES OF THE ANTENATAL COMPUTER CARDIOFLOWGRAPHY IN THE ESTIMSTION OF THE COHDITION OF THE FETUS IN THE III TRIMESTER OF PREGNANCY

Year: 2006, volume 2 Issue: №3 Pages: 52-55
Heading: Obstetrics and Gynecology Article type: Original article
Authors: M.L. Chekhonatskaja, P.V. Glibochko, G.I. Hripunova, O.I. Guskova
Organization: Saratov State Medical University
Summary:

The purpose of research – the analysis of the results CFG in the diagnostics of the condition of the fetus and the estimation of the function мочевыделительной systems according to the prenatal cistometri.
Material and methods. The study of the cardioflowgraphy with the analysis of the values of the integrated parameter of the fetus and the urodinamic parameters of the top and the bottom uric ways at 102 fetus in III trimester of the pregnancy the method which consists in the monitoring process of the filling and evacuation the bladder are studied.
Results. Carried out researches have shown, that the fetus with the expressed infringement (coefficient from 2,1 up to 3) or the critical condition (coefficient from 3,1 up to 4) infringements of function of the bottom uric ways have been revealed in 22 (59,5%) a cases.
The conclusion. The precise interrelation between ПСП, the condition urination function of the fetus and the newborn is observed. Thus most early the symptoms testifying to the pathology from urination system, appear at the children who have transferred heavy intra-uterine gypoxiy. The first clinical displays is the uric syndrome.

Keywords: fetus, pregnancy

INFLUENCE OF FEATURES OF THE CURRENT OF THE PREGNANCY ON THE DEVELOPMENT OF THE INFECTION OF THE URIC SYSTEM OF THE NEWBORNS

Year: 2006, volume 2 Issue: №2 Pages: 58-63
Heading: Obstetrics and Gynecology Article type: Original article
Authors: M.L. Chehonatskaj, P.V. Glybochko, I.V. Mihajlov, G.I. Hripunova, T.A. Gasanova, F.G. Zabozlaev, L.G. Bochkova, V.G. Fajustova
Organization: Saratov State Medical University
Summary:

The purpose of the present research was studying features of current of the pregnancy and sorts of 125 women and their influence on the development of the infection of the uric system of the newborns.
The preconditions to the development of development of the infection of the uric system in the newborn are formed in the period of intra-uterine development and defined on the one hand by features of the development of the uric system of the fetus and on the other hand – a condition of the parent organism.
From the fetus most often came to light pyeloectasia – in 42,9% of supervision, hydronephrosis – in 22,4% and megaurether - 20,4% .
The risk factors from the parent organism are: hereditary aggravate on the disease of kidneys in the family ,chronic inflammatory disease of the bodies of a small basin ,presence a herpes-virus of the infection ,the aggravation of the chronic inflammatory process , transferred ОРВИ during of the pregnancy , the placentofetal insufficiency, premature birth.
Significant percent intra-uterine hypotrophy and infection , confirm pathogenic action hypoxia and mixt-infection on the formation of a pathology the uric system of the fetus and the newborn and emphasize necessity of the forecasting and preventive maintenance of the given complication.

Keywords: newborn, pregnancy

PECULIARITIES OF GESTASION IN PREGNANT WOMEN WITH METABOLIC SYNDROME

Year: 2007, volume 3 Issue: №3 Pages: 62-64
Heading: Obstetrics and Gynecology Article type: Original article
Authors: R.R. Berihanova, G.I. Khripunova
Organization: Saratov State Medical University
Summary:

The article presents the peculiarities of gestasion in pregnant women with metabolic syndrome. The obtained findings testify that metabolic syndrome is a factor of high risk in the development of gestosis, fetoplacental insufficiency and another obstetrical complication.

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ABOUT THE ROLE OF ENDOTHELIAL DYSFUNCTION IN GESTOSIS DEVELOPMENT

Year: 2007, volume 3 Issue: №3 Pages: 60-62
Heading: Obstetrics and Gynecology Article type: Original article
Authors: G.I. Khripunova, E.V. Ponukalina, G.S. Salakhieva
Organization: Saratov State Medical University
Summary:

The complex clinical and laboratory researches conducted in groups of the pregnant women with mild case of gestosis, middle serious preeclampsia and with heavys everity of gestosis. Anticoagulation and fibrinolytic activity of a wall of vessels on a background of creation of a short-lived ischemia were examined. Disturbance of a coagulative potential of a blood are actuated development endothelial dysfunction in groups of the pregnant women with middle serious preeclampsia and with heavy severity of gestosis.

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DEVELOPMENTAL DYNAMICS OF VEGETATIVE DISORDERS AND THEIR PECULIARITIES IN VARIOUS PHASES OF PERIMENOPAUSE IN WOMEN

Year: 2008, volume 4 Issue: №4 Pages: 30-32
Heading: Obstetrics and Gynecology Article type: Original article
Authors: N.V. Dyo, G.I. Khripunova
Organization: Saratov State Medical University
Summary:

The article is reffered to the dynamics of vegetative disorders' development in case of physiological and pathological course of menopause. The findings show that vegetative disorders significantly contribute to the development of pathological conditions accompanying the menopause

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MODERN APPROACHES TO DIAGNOSTICS, FORECASTING OF CURRENT AND TREATMENT OF CLIMACTERIC SYNDROME AT WOMEN

Year: 2008, volume 4 Issue: №3 Pages: 125-130
Heading: Obstetrics and Gynecology Article type: Review
Authors: N.V.Dyo, G.I.Khripunova
Organization: Saratov State Medical University
Summary:

The article reflects modern literary data about approaches to diagnostics, forecasting of current and treatment of a climacteric syndrome at women.

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CONTEMPORARY CONSIDERATIONS ON ETHIOLOGY, PATHOGENESIS, DIAGNOSTIC METHODS AND TREATMENT OF BACKGROUND AND PRECANCER DISEASES OF CERVIX

Year: 2008, volume 4 Issue: №2 Pages: 18-26
Heading: Reviews Article type: Review
Authors: S.N. Gribova, G.I. Khripunova
Organization: Saratov State Medical University
Summary:

Taking into consideration the data of Russian and foreign literature, incidences, development, features of clinical course of background and precancer diseases ofcervixare covered in this research. The role of recent diagnostic and treating methods in prophylaxis of cervix cancer is also highlighted.

Keywords: -
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PECULIARITIES OF CHANGES ОF IMMUNOREGULATORY SYSTEM OF WOMEN WITH BACKGROUNG PATHOLOGY OF UTERINE CERVIX (NA)

Year: 2009, volume 5 Issue: №1 Pages: 49-51
Heading: Obstetrics and Gynecology Article type: Original article
Authors: S.N. Gribova, G.I. Khripunova, N.B. Zakharova
Organization: Saratov State Medical University
Summary:

A comparative research of cytokines IL-1b, IL-4, IL-6, IL-8, INF-/, TNF-a and its concentration in cellular material suspension on surface of pseudo erosion of uterine cervix was carried out. It was clarified that inefficient activation of local protective factors of immune system plays the main role in clinical behavior of pseudo erosion of uterine cervix. Imbalance of cytokines output to pro-inflammatory factors was observed.

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