Saratov JOURNAL of Medical and Scientific Research

children

On the clinical picture and diagnosis of rare neurological diseases

Year: 2018, volume 14 Issue: №1 Pages: 174-177
Heading: Neurology Article type: Case report
Authors: Ulyanova O.V., Kutashov V.A., Brezhneva N.V.
Organization: Regional Children's Clinical Hospital No. 1 (Voronezh), Voronezh State Medical Academy
Summary:

 The article presents clinical observation of patient H, 2007 year of birth., with X-linked adrenoleukodystrophy (X-ALD). This is a rare hereditary metabolic disease, not only in Russia but also worldwide. It belongs to the group of peroxisomal diseases, is associated with the accumulation of fatty acids with a very long chain and is characterized by a combined lesion of the nervous system and adrenal glands. X-ALD in neurology and Pediatrics require a targeted individual approach to each patient, genetic tests in relatives and prenatal diagnosis among patients at risk.

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Research on the level of thyroid-stimulating hormone and thyroid hormones in children with neuroinfections to evaluate the process of adaptation

Year: 2018, volume 14 Issue: №1 Pages: 65-69
Heading: Infectious Diseases Article type: Original article
Authors: Zakharova I.S., Malyugina T.N.
Organization: Saratov State Medical University
Summary:

The aim is to study the features of the adaptation process in children of different ages with acute neuroinfections depending on the etiology, severity of the disease and the period of the disease using indicators of the pituitary-thyroid system. Material and Methods. A comprehensive clinical and laboratorial checkup of 237 children with different noso-logical forms of neuroinfections was carried out: meningitis: viral, enteroviral, purulent and cerebromeningitis. Control board group was composed of 15 healthy children of the identical age. All the patients underwent the thyroid-stimulating hormone and thyroid hormones blood serum level, IFA technique being used, during acuity and reconvalesence. Re-sults. The neuroinfections status of the pituitary-thyroid system depends on the period and severity of the disease and does not depend on the etiology, age and sex of the child. Conclusion. According to the indices of the pituitary-thyroid system revealed that different adaptive responses develop in neuroinfections depending on the reactivity of child's organism and severity of the disease.

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The cytokine status and the levels of thyroid hormones in children with acute respiratory viral infections

Year: 2018, volume 14 Issue: №1 Pages: 61-65
Heading: Infectious Diseases Article type: Original article
Authors: Malinina N.V., Malyugina T.N.
Organization: Saratov State Medical University
Summary:

The research goal is to study the performance of INF-а, INF-y and IL-1(3 in children with acute respiratory viral infection (ARVI) depending on etiology, the presence of mixed infection, disease severity, presence of complications, the concentration of thyroid hormones. Material and Methods. Examined 147 patients aged from 1 to 10 years at the outbreak of the ARVI and 15 healthy children. Patients in the midst of acute respiratory infections was conducted to determine levels of IL-1(3, INF-а, INF-y, triiodothyronine (T3) and free thyroxine free (T4) by ELISA using standard test kits JSC "Vector-best" (Koltsovo, Novosibirsk region). Results. It was showed elevated level of INF-y in patients with PC-infection in comparison with the same indicator in healthy children. Set the increased level of INF-а in severe ARVI and the level of INF-y at medium severe form. It was showed increased levels of INF-y in patients with mixed infection. In children with complications, the level of IL-1 (3 was lower almost in 2.4 times, than in children without complications. Among patients with complications, the highest numbers of INF-а were detected in children with pneumonia and INF-y increased in patients with bronchitis. When conducting correlation analysis, the highest rates of INF-а were observed in children with the syndrome of "low T3", and INF-y in children as low T3 and low T4. Conclusion. An increase in the level of INF-y in patients with RS infection was found. Revealed that in children in acute period of SARS levels IL-1 IS, INF-а do not depend on the etiological factor of SARS. These indicators are influenced by the severity of the disease, which in our study was due to the development of mixed infection, the presence and nature of complications. High rates of INF-а and INF-y have significant inverse correlation with the level of T3, which reflects the degree of intoxication in the acute period of infectious diseases.

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Talipes equinovarus in children

Year: 2017, volume 13 Issue: №3 Pages: 514-520
Heading: Traumatology and Orthopedics Article type: Review
Authors: Timaev M.Kh., Sertakova A.V., Kurkin S.A., Rubashkin S.A., Anisimova E.A., Anisimov D.l.
Organization: Scientific Research Institute of Traumatology Orthopedics and Neurosurgery of Saratov State Medical University n.a. V.I. Razumovsky
Summary:

The research goal of the review is to present data on etiology, prevalence, classification of different types TEN/ in children. Mechanisms of pathological foot type, indications for conservative and surgical methods of treatment have been analyzed.

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Characteristics of cases with poor outcomes of rendering medical care to children in six regions of the Russian Federation

Year: 2017, volume 13 Issue: №1 Pages: 010-013
Heading: Forensic medicine Article type: Original article
Authors: Erofeev S.V., Kupryushin A.S., Efimov А.А., vishnyakova Zh.S., Semina M.N.
Organization: Bureau of Forensic Medical Examination of the Ivanovo Region, Ivanovo State Medical Academy, Penza State University, Saratov State Medical University
Summary:

Objective: to determine the characteristics of the outcome of the improper care for children, established during the commission of forensic examinations. Material and Methods. The material of this study was commission a forensic medical examination of the archives department of complex expertise of the Bureaus of Forensic Medicine of Moscow; the Moscow, Penza, Samara and Ulyanovsk regions, and the Republic of Mordovia, conducted from 1996 to 2006. The method of this study was a statistical database processing using Excel software application package. Results. The article presents the results of the analysis of 279 forensic medical examinations conducted by committees in the Bureaus of Forensic Medical Examination of Moscow; the Moscow, Penza, Samara and Ulyanovsk regions, and the Republic of Mordovia from 1996 to 2006. The examinations were conducted in connection with poor outcomes of rendering medical care to children. Conclusion. The number of conducted examinations correlates with the population of the region. The parents of the children affected by poor treatment mostly demand the medical staff to be prosecuted and more often make legal claims to the quality of emergency medical care; dissatisfaction with the quality of medical care is more often expressed by the parents of children under 3 years old. Legal claims are more often made against obstetricians-gynecologists, pediatricians, surgeons, infectious disease specialists and anesthesiologists-resuscitators. If the conclusion of the forensic medical examination committee on the nature of the pathological process coincides with the final clinical diagnosis, the provided medical care often turns out to be adequate; in cases of inadequate medical care the risks of moderate and grievous bodily harm as well as the patient's death are high.

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Clinical case of a Goldenhar syndrome diagnostics in a newborn boy

Year: 2016, volume 12 Issue: №3 Pages: 511-513
Heading: Dermatovenerology Article type: Case report
Authors: Slesarenko N.A., Eremina M.G., Belonogova Y.V., Roshepkin V.V., Eremin A.V.
Organization: Saratov State Medical University
Summary:

Relative importance of the current issue is based on rare occurrence of this dermatosis, its genetic predisposition and occurrence in early childhood. The Goldenhar syndrome diagnosing is a difficult task and causes difficulty in selecting treatment, due to large number of clinical syndromes presenting with facial deformities and the inability to quickly identify concomitant signs of damage to other organs and systems.

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Headache in pediatric practice: multifactor analysis of clinical and social predictors

Year: 2015, volume 11 Issue: №4 Pages: 548-551
Heading: Pediatrics Article type: Original article
Authors: Akhmadeeva L.R., Valeeva D.S., Veytsman B.A., Akhmadeeva E.N.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

The purpose of this work is to define the clinical and social predictors of headaches in children and adolescents. Material and Methods. We performed clinical examination of children and adolescents, which included studying their symptoms, anamnesis, somatic and neurological objective signs, survey using our original questionnaire and survey in the framework of an international project to study headaches «World Children and Adolescent Headache Project». The type of headache was diagnosed using international diagnostic criteria of the International Classification of Headache Disorders, 3rd edition (beta release). As a result of our study, we obtained the data about the most significant lifestyle factors (among those studied) influencing the number of days with headache per month, calculated linear coefficients and a predicting mathematical model for children. The sensitivity of the model for the prognosis of chronic tension type headache is 63%, specificity — 81 %. Conclusion. In this paper we describe criteria for the prognosis of primary headaches in patients aged from 8 to 18 years old.

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Health assessment of children and adolescents living in a residential area of production for the disposal of rocket fuel: according to the results of the medical examination

Summary:

Aim: to determine the real prevalence separate nosological forms in the child population living in residential zone installations for the disposal of rocket fuel. Materials and methods. By mobile teams of pediatric physicians there was conducted a comprehensive medical examination of 1621 children in the area of the site location for disposal of rocket engines solid fuel. Results. The surveyed contingent of the most common diseases of the endocrine system, disorders of nutrition and metabolism (21.2% of diagnoses), diseases of the musculoskeletal and connective tissue (19.2 percent), as well as individual symptoms, signs and deviations from the norm by 14.4%. Conclusion. Data indicating the pronounced impact of adverse environmental factors, not identified.

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Changes in internal architectonics of proximal femur in children with hip dysplasia development

Year: 2014, volume 10 Issue: №4 Pages: 635-638
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Dokhov M.M., Barabash A.P.
Organization:
Summary:

The aim of the research is to identify common patterns of compensatory changes in internal architectonics of the proximal femur with valgus and varus deformity. Material and Methods. The parameters of the proximal femur were determined on the basis of 78 roentgenograms of children with hip dysplasia (1-4 years, 4-7 years, 7-16 years) before and after surgical treatment (after 6 months). Results. The degree of change in internal architectonics of the bone substance has been determined after changing of the femoral neck-shaft angle achieved with the help of correcting osteotomy in different age groups. Conclusion. Maximum recovery of internal architectonics of the bone substance is observed in the groups aged 4-7 years.

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Incidence of syphilis among children in Saratov region in 2009-2013

Year: 2014, volume 10 Issue: №3 Pages: 504-308
Heading: Skin Diseases Article type: Author's opinion
Authors: Persashvili M.A., Sherstneva V.N., Utz D.S., Sherstobitova L.A.
Organization: Saratov State Medical University, SEH «Saratov regional dermatovenerologic dispensary»
Summary:

The article presents incidence analysis results of congenital and acquired syphilis among children in Saratov region in 2009-2013.

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