Saratov JOURNAL of Medical and Scientific Research

Erokhin A.N.

Kurgan "Russian Scientific Centre "Reconstructive Traumatology and Orthopedics" named after acad. G.A.IIizarov under Federal Agency for High-tech Medical Care”, Head of Clinical-Experimental Scientific Department of Physiology, Assistant Professor, Doctor of Medical Science

Microelement content of bone tissue in transosseous osteosynthesis by II-izarov technique in high-altitude destinations (experimental research

Year: 2014, volume 10 Issue: №1 Pages: 119-123
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Erokhin A.N., Isakov B.D., Nakoskin A.N.
Organization: Bishkek State Medical Academy, Russian Ilizarov Scientific Center «Restorative Traumatology and Orthopaedics»

Aim: To study the redistribution of microelements in bone tissue in osteosynthesis in high-altitude destinations. Material and Methods. The study was performed on 72 mongrel dogs of both sexes aged 1-3 years, weighing 10—15 kg. 32 dogs have been experienced the extended leg in lowlands destinations, another group of 32 animals have been experienced elongation produced in high-altitude destinations. The control group consisted of 8 healthy dogs of low mountain areas. The standard technique of surgery has been used in the research. Microelement composition has been studied by atomic absorption spectrophotometer AAS-1 N (Germany) in the long bones and the distraction regenerate. Shapiro —Wilk test was applied to analyze the normality. The data evaluation has been done by Student's t-test for unpaired samples. Results. Calcium and microelement imbalance has been obtained during transosseous osteosynthesis in high-altitude destinations, which causes functional changes in the musculoskeletal system, with similar clinical picture of Kashin — Beck. In the conditions of high-altitude destinations elongation of bones causes changes in microelements in the distraction regenerate. Conclusion. During distraction osteosynthesis in high-altitude destinations phase changes of microelements have been formed in the bone regenerate, which prognoses physiologically the formation of a false joint.

2014_01_119-123.pdf388.02 KB

Peculiarities of homeostatic system in highland conditions using llizarov distraction transosseous osteosynthesis method


Purpose. The purpose is to study the reaction of homeostasis system in stable and in distraction llizarov transosseous ostesysnthesis of the limbs bones at experimental animals (dogs) in highland conditions. Material and Methods. 63 adult mongrels aged from 1 to 3 years with 10-20 kg body weight and 15 cm minimal length of tibia were included in the experiment. Open osteosotmy of tibial mid-shaft followed by Kirschner wires insertion through tibial bone and llizarov frame assembly comprising 3 or 4 rings was performed under IV anaesthesia at 3200 m altitude above sea level. In experimental group including 33 mongrels the distraction was performed on the 5th day after osteotomy by 1 mm rate divided into 4 times within 10 days but in control group comprising 30 dogs the distraction was not provided. Every 10 days after distraction blood samples were taken in both groups to examine coagulation; the samples were taken from subcutaneous lateral tibial vein, ex tempora mixing with 3,8% solution of sodium citrate at 9:1 ratio. Then the plasma was separated and examined biochemically according to the accepted standards. Results. We obtained the data witnessing activation of coagulation component of homeostatic system in stable osteosynthesis of the limb bones using llizarov fixator with simultaneous inhibition of fibrinolytic component. In distraction osteosynthesis hyper-coagulation trend in homeostasis system with simultaneous suppression of fibrinolytic blood activity is vividly defined within the entire experiment period. Conclusion. Transosseous distraction osteosynthesis in highland condition causes considerable shifts in the system of homeostasis with definite domination of coagulation component which promotes formation of pre-thrombotic condition. Limb segment lengthening on the background of pre-thrombotic condition increases the risk of thromboembolic complications in highland conditions and requires appropriate measures of prophylaxis

201202_308-312.pdf293.56 KB



We studied 21 patients (15 females and 6 males) at the age of 11 to 69 with congenital anomalies of limbs development and trauma consequences. At different stages oftransosseous osteosynthesis we studied the dynamics of subjective and objective signs that reflect the changes in peripheral blood flow under the influence of reflexotherapy. We worked out and approved the ways for registration of the dynamics of subjective and objective characteristics of regional blood flow under the influence of pressure of acupunctural zones in orthopedics and trauma patients treating them byllizarov’s method. It was found out that acupunctural zones pressure cause data increase and prove increased blood supply in the observed segment It was marked that with this effect reflexotherapy can accelerate the process of patients' rehabilitation

2008_04_108_112.pdf234.11 KB