Saratov JOURNAL of Medical and Scientific Research

Katunina N.P.

Bryansk State University

THE INFLUENCE OF PHENYL-ETHYL-SUBSTITUTED DERIVATIVES OF 3-OXIPYRIDINE ON THE LIFE INTERVAL OF MICE UNDER ACUTE HYPOXIA WITH HYPERCAPNIA AND ACUTE HYPOBARIC HYPOXIA

Year: 2007, volume 3 Issue: №1 Pages: 100-103
Heading: Physiology and Pathophysiology Article type: Short message
Authors: N.P. Katunina, M.P. Katunin
Organization: Bryansk State University
Summary:

The subject of our study was the influence of 22-phenyl-ethyl-substituted derivative of 3-oxipyridine (3-OP) and 5 nedicines having antihypoxic and/or antioxidant characteristics (Mexidolum, Emoxipine, Etomerzolum, Nooglutilum, Natrii xibutyras) on the life interval of mice under acute hypoxia with hypercapnia (AHwHc) and acute hypobaric hypoxia (AHBH). he antihypoxic influence of the combinations is revealed to depend on their chemical structure, dose and model of acute ypoxia. The life interval of mice was being increased with the help of6 phenyl-ethyl-substituted derivatives of 3-OP under HwHc and 5 derivatives underAHBH. The composition CK-131 in cipher with the range of effective doses (50-200 mg/kg) nd antihypoxic activity (30-120 % increase in the life interval of mice) considerably exceeds other studied substances and ledicines in comparison Mexidolum, Emoxipine, Nooglutilum, Etomerzolum, Natrii oxibutyras under AHwHc and AHBH. The omposition CK-131 may be recommended for further study as a long-range antihypoxant.

Keywords: antioxidant

EXPERIMENTAL STUDY OF THE ANTIHYPOXIC ACTIVITY OF NEW PHYSIOLOGICALLY COMPATIBLE ANTIOXIDANTS ON THE MODELS OF ACUTE HEMIC AND HISTOTOXIC HYPOXIA

Year: 2007, volume 3 Issue: №1 Pages: 99-100
Heading: Physiology and Pathophysiology Article type: Short message
Authors: N.P. Katunina, M. P. Katunin, E. V. Afonina, V. E. Novikov, E. A. Parfenov
Organization: Bryansk State University
Summary:

There is a complex composition of cuprum, pQ-1032 in cipher, revealed among 13 new physiologically compatible antioxidants (PCAO). This composition with the range of effective doses (10, 25, 50, and 100 mg/kg) and the degree of antihypoxic activity (26-36% increase in the life interval of mice) considerably exceeds other studied substances and well-known antihypoxants Emoxipine, Etomerzolum, Mexidolum, Nooglutilum, Natrii oxibutyras under acute hemic and histotoxic hypoxia. pQ-1032 may be recommended for further study and its possible application as an antihypoxant in clinics.

Keywords: antioxidant