Saratov JOURNAL of Medical and Scientific Research

Institute of Clinical Pharmacology

BETA-ADRENORECEPTORS GENETIC POLYMORPHISM CONNECTION WITH BETA-BLOKER THERAPY EFFICACY IN PATIENTS WITH CARDIOVASCULAR DISORDERS

Year: 2009, volume 5 Issue: №1 Pages: 41-44
Heading: Clinical Pharmacology Article type: Original article
Authors: A.N. Levanov, I.V. Ignatyev, D.A. Sychev, S.I. Bogoslovskaya, A.A. Svistunov
Organization: Saratov State Medical University, First Moscow State Medical University n.a. I.M. Sechenov, Institute of Clinical Pharmacology
Summary:

At present it is obvious that genetic peculiarities of patients are the major reason for individual differences in pharmacological responses to (?-adrenoblockers. Furthermore ADRB1 gene polymorphism is responsible for the efficiency of (?-adrenoblockers. Thus, a real prospect exists for an individualized approach to administration of (?-adrenoblockers and selection of dosage based on patient’s genotype, which must undoubtedly increase efficiency of the administered therapy. Reviewfocuses on gene polymorphism responsible for (?-adrenoblockers pharmacodynamics and on the clinical significance of the polymorphism detection to individualize drug therapy based on patient’s genotype.

AttachmentSize
200901_041_044.pdf207.86 KB