Saratov JOURNAL of Medical and Scientific Research


Cortisol level as a marker of adaptation processes in children with acute respiratory viral infections

Year: 2018, volume 14 Issue: №4 Pages: 646-650
Heading: Infectious Diseases Article type: Original article
Authors: Malyugina T.N., Malinina N.V., Averianov А.Р.
Organization: Saratov State Medical University

Aim: to study changes in the level of cortisol in children in the acute period of respiratory viral infection, depending on the etiology, severity of the disease and the presence and nature of the developed complications to establish an adaptation option. Material and Methods. 74 patients aged 1 to 10 years on day 1-3 from the beginning ofARVI (adeno-virus, parainfluenza, respiratory syncytial infection and mixed infection) and 15 healthy children were examined. The etiology ofARVI was established by PCR. Patients in the first three days from the beginning ofARVI were determined by the level of cortisol by the method, according to the indications, chest x-ray examination was performed. The type of adaptive response in children was determined by the value of the lymphocytic index and the level of cortisol in the blood serum. Results. The study showed that in children with ARVI there is a different reaction of the adrenal glands to the disease, which is characterized by both an increase and a decrease in their function. An increase in cortisol concentration characteristic of an adequate adaptation reaction was found in 59.2% of patients. In 12.3% of children noted a decrease in cortisol compared with the control group, in the remaining patients (28.5%) cortisol content did not differ from that in healthy children. Adaptation by the reaction type of "stress" alarm stage was observed in 37.1 % of children, the reaction of "stress" in the stage of resistance at 14.3% of patients, the reaction of "stress" with the development

2018_4_646-650.pdf287.56 KB

Correlation of cardiointervalometric and somatosensory evoked potential parameters in male and female patients with epilepsy

Year: 2017, volume 13 Issue: №1 Pages: 149-154
Heading: Neurology Article type: Original article
Authors: Lesik О.О., Zhadnov V.A.
Organization: Ryazan State Medical University n.a. I.L.Pavlov

Somatosensory evoked potentials and cardiointervalometry can be used as additional methods of examination of patients with epilepsy. Aim: determination of relationships between functional state of the brain and stress on regulatory systems, so as to assess the adaptive potential of male and female patients with epilepsy. Materials and methods. 46 male patients (group 1) and 34 female patients (group 2) diagnosed with epilepsy participated in the study. Analyzed parameters included maximum amplitude, total area of somatosensory evoked potentials and cardio-intervalometric parameters. Results. In patients with epilepsy, there is an increase in EAP indicators that suggestive of increased neu-ronal synchronization. However, with hyperventilation physiological probe, male patients demonstrated inhibition while female patients demonstrated stimulating effect of the brain. This tendency persisted in both groups of patients after hyperventilation. Cardiointervalometric findings in female patients were consistent with vagotony, indicative of normal activity of regulatory systems and the autonomous regulation of heart rhythm. Male patients with epilepsy require significant energy in order to adapt to the load, resulting to stress of regulatory systems. Conclusion. Additional methods of examination identify features of the functional state of the brain and stress on regulatory systems in male and female patients with epilepsy. Signs of disadaptation and unfavorable course ofthe disease allow timely diagnosis and improve the quality of life ofthe patient.

2017_01-1_149-154.pdf244.02 KB

Multifocal atherosclerosis in patient after acute first degree radiation sickness.

Year: 2014, volume 10 Issue: №4 Pages: 862-867
Heading: radiation medicine Article type: Case report
Authors: Metlyaeva N.A., Lartsev M.A., Shcherbatykh O.V., Bushmanov A.Yu., Krasnyuk V.I.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency

Purpose: assessment the heavy psychosomatic and all-somatic cardiovascular and cerebrovascular pathology of patient, transferred an acute I degree radiation sickness, from the general evenly gamma-beta radiation. Conclusions. The subdepressive and disturbing-depressive syndrome of patient, transferred an acute radiation sickness (ARS) of I degree, from the general evenly gamma-beta radiation, was independent risk factor of development of multifocal atherosclerosis; Features of development of all-somatic and psychosomatic pathology of patient are based on a combination of genetic prerequisites, environment influences (the stress caused by accident on the ChNPP) and social factors, influencing on him during a course of life, especially during early socialization. Thus at development of psychosomatic frustration the combination of feature of the mental reaction connected with the personal characteristic and special relationship between mental (stress) and physiological (somatic) by aspects of reaction which led to metabolism violation, to aging, decrease in adaptation opportunities of an organism and development age — dependent pathology took place.

2014_04-01_862-867.pdf298.77 KB

Psychophysiological adaptation of the patient with the remote effect of the III degree acute radiation syndrome

Year: 2013, volume 9 Issue: №4 Pages: 897-901
Heading: radiation medicine Article type: Original article
Authors: Metlyaeva N.A., Lartsev М.А., Shcherbatykh О.V., Bushmanov A.Yu.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency

Aim: clinical psychophysiological assessment of social and psychophysiological adaptation of the patient with the remote effect of the III degree acute radiation syndrome, with local radiation injuries of heavy degree from the extremely uneven gamma and neutron radiation with the subsequent amputation of both feet at level in top / 3 shins, according to feature of its individual mental adaptation and the periods of its mental adaptation stages. Material and methods. The object of the research was a patient (born in 1939) who worked as an engineer in the National Research Centre (NRC "Kurchatov Institute") from 1963 to 2010, the senior researcher. Psychophysiological inspection of the patient had been organized according to the MMPI test, Kettell's test, Raven in 30 years after radiation accident (1971) in dynamics in 2001, 2002, 2006, 2009 with the use of the automated program and methodical Expert complex intended for research of the properties, cognitive and intellectual features of the personality. Results. Average profile of multilateral research of the personality (MMPI) and the dynamics of indicators according to the years of supervision (2001-2009) points to a disharmonious combination of hypochondriac, disturbing and depressive and demonstrative tendencies to prevalence of a demonstration, as firmness manifestation before a heavy illness at the patient after the III degree acute radiation sickness, and local radiation injuries of heavy degree from the extremely uneven gamma and neutron radiation, am-
putation of both shins at level in top / 3, late beam buttock, right hip ulcers, a beam cataract of the III degree of both eyes, stabilized. The assessment of the efficiency of psychophysiological adaptation in dynamics with 2009 indicates emergence of prevalence of hypochondriac tendencies over a demonstration with accession of high uneasiness and autistic lines at preservation of the leading role of an hypochondriac somatization of alarm with considerable decrease in an emotionality, an integration, a freedom of behavior. The changes revealed in dynamics correspond to the specific increase weight of violations of mental adaptation, characteristic for the period of adaptation exhaustion. The high intelligence, good figurative and logical thinking, well-mannered forms of behavior, high control over the emotional sphere, restraint of emotions, independence, self-sufficiency, organization, behavior taking into account environment requirements provided the patient M. firmness before a heavy illness, promoted good adaptation to an environment with confidence in myself, high social adaptability, opportunity successfully to carry out duties, hold the work account (worked 39 years after accident). Comparative assessment of operator ability of the patient M. showed good average time of common and difficult sensorimotor reactions with 2 mistakes, high time of reaction for moving object, however decrease in accuracy of reaction from 10-13% to 2% testifies to manifestation in dynamics of insufficiency of real functional reserves of nervous system. Conclusions. Efficiency of psychophysiological adaptation depends not only on a dose of radiation and weight of the transferred disease, but, mostly, on premorbid properties of the identity of the victim and his social and labor installation.

2013_04-01_897-901.pdf611.99 KB

Adaptive capacity of individuals suffered from diphtheria

Year: 2013, volume 9 Issue: №2 Pages: 178-186
Heading: Infectious Diseases Article type: Original article
Authors: Maleev V.V., Malyugina T.N., Zaytseva I.A., Tseka Yu.S.
Organization: Saratov State Medical University, Central Research Institute of Epidemiology

The purpose is to reveal functional violations of various organs and systems at persons who have suffered from diphtheria and to develop algorithm of medical examination. Material and methods: 10 years» observation of over 722 patients who have had diphtheria has been made. Nuclear heating plants, ALT, glucose, urea, creatinine, troponin, blood myoglobin, creatinine of urine, SKF, LPI, anti-toxic antibodies, organ authoantibodies, interferons, AKTG, a corti-sol, TTG, ТЗ, T4, insulin and S-peptide, authoantibodies to thyroglobulin have been determined, an electrocardiogram, Doppler — and an echocardiography have been carried out. Results: It is revealed that at 59% of the persons who have had diphtheria, in the first three years catamnesis included the pathology of cardiovascular, nervous and urinary systems caused by existence of complications and a form of diphtheria in the acute period was created. It was accompanied by violation of functions of immune and hormonal systems: there was no protective anti-toxic immunity, autoimmune process was started, activity of the central and vegetative endocrine glands decreased. Depending on extent of these violations various options of disturbance of adaptation have been developed. At 5% of patients disturbance of adaptation resulted in lethal outcome. Conclusion: Functional violations of various organs and systems in catamnesis in persons who have had diphtheria have been revealed. The algorithm of medical examination for the purpose of regulation and correction of process of their adaptation has been offered.

2013-02_178-186.pdf297.08 KB

Optimization of phonetic adaptation in patients after stomatological treatment as a way of medical care improvement

Year: 2012, volume 8 Issue: №1 Pages: 114-116
Heading: Stomatology Article type: Original article
Authors: Firsova I.V., Mikhalchenko D.V., Mikhalchenko A.V., Poroshin A.V.
Organization: Volgograd State Medical University

Purpose: develop a methodology for optimizing the phonetic adaptation of patients after dental treatment. Materials and methods. A group of people after the orthopedic treatment or extensive restoration work with sound correction and without it has been studied. In order to correct sounds used technique of adaptive biocontrol with feedback. Results. The importance and effectiveness of adaptive biocontrol techniques with feedback in the optimization of phonetic adaptation. Conclusion. Method of phonetic adaptation optimization, which allows to reduce the rehabilitation period, and thus improves the quality of life in patients of dental profile.

201201_114-116_.pdf321.87 KB

Correlation of self-regulation of perception functional systems with characteristics and functions of attention

Year: 2011, volume 7 Issue: №4 Pages: 791-795
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Berdnikov D.V., Bobyntsev I.I.
Organization: Kursk State Medical University, Kursk Forensic Laboratory

The purpose of the research: to study the relation of the voluntary visual attention to the self-regulation of different functional information comprehension systems. The object of the research: 196 individuals, aged 18-26 years, having no complaints of their health status. The techniques used: those of comprehension and measuring the pure tone length, the spatio-temporal parameters of the stimulus and the instrumental-software complex for studying the properties of attention. The results of the research have demonstrated that realizing its properties through the control functions attention exerts an active influence on the functional comprehension systems self-regulation. Conclusion: We have proved the integration of the function of attention into the self-regulation processes

201104_791-795.pdf291.84 KB

Adaptation of one-year conscripts to military professional activity: investigation and optimization

Year: 2011, volume 7 Issue: №1 Pages: 021-026
Heading: Health Service Organization Article type: Original article
Authors: Korshever N.G., Sitmbetov D.A.
Organization: State Military Hospital № 250, Saratov State Medical University

The study of organism functional status, social and psychological characteristics and morbidity rate of one-year conscripts (control group) makes possible to state that their adaptation to the conditions of military professional activity is significantly higher than that of two-year conscripts (group of comparison). It also helps design a multicriteria approach of assessment of positive individual adaptation and plan adequate optimization technology

201101_021-026.pdf422.2 KB

Physiological assessment of military professional adaptation and organism functional status of higher military schools resident students


The results of the study of organism functional status of resident students of military medical higher schools in different situations and modes of professional education (during their study day, round-the clock shifts in a clinic, duties, and an examination period) in the process of military professional adaptation have been analyzed. The technique of functional body status optimization which takes into account both psycho-physiological specificity of military professional training as well as the regularities of psycho-physiologic reserve-capacity changes and military professional adaptation has been worked out. It constitutes the sum total of physiologically proved structural and functional components such as adaptation improvements, correction and recreation of functional body status

201003_516_521.pdf276.24 KB


Year: 2008, volume 4 Issue: №4 Pages: 46-49
Heading: Internal Diseases Article type: Original article
Authors: S.V. Semenov, E.I. Kashkina
Organization: Saratov State Medical University, Saratov Military Medical Institute

The presence of connective tissue undifferentiated dysplasia syndrome against a background of psychological stress at newly recruited can promote the risk of gastroesophageal reflux disease occurrence. To the utmost, correlation between the gastroesophageal reflux disease and such manifestations of connective tissue undifferentiated dysplasia syndrome as asthenic constitution, chest deformation, Gothic palate and hypermobility of joints was found

2008_04_046_049.pdf183.55 KB