Saratov JOURNAL of Medical and Scientific Research

Bogoslovskaya S.I.

Saratov State Medical University, Department of Pharmacology and Clinical Pharmacology, Professor, Doctor of Medical Science

Critical problem of clinical pathogenicity of Helicobacter pylori in gastroen-terology

Year: 2014, volume 10 Issue: №1 Pages: 96-102
Heading: Clinical Pharmacology Article type: Review
Authors: Belova O.L., Bogoslovskaya S.I., Belova I.M.
Organization: Saratov State Medical University
Summary:

In discussional article argue unfounded of infectious hypothesis of the pathogenesis of ulceral disease of gastric and duodenum.

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Renal dysfunction and state of metabolic and hemodynamic factors in patients with arterial hypertension

Year: 2011, volume 7 Issue: №4 Pages: 837-842
Heading: Internal Diseases Article type: Original article
Authors: Kurkina T.V., Bogoslovskaya S.I., Svistunov А.А., Kodochigova A.L, Glybochko G.Kh., Klochkov V.A.
Organization: Saratov State Medical University, Saratov Regional Hospital for Veterans of Wars, Saratov Institute of Cardiology, Russia, First Moscow State Medical University n.a. I.M. Sechenov
Summary:

The aim of the investigation is to carry out comparative evaluation of metabolic and hemodynamic indices in patients with arterial hypertension (AH) and renal dysfunction; to study the interrelation between arterial blood pressure level normalization and the presence or lack of microalbuminuria (MAU) in the morning urine portion of patients with AH after therapy with antihypertensive preparations (APs) of various groups. Methods. 121 persons have been investigated, 91 out — patients of both sexes, aged 33-55, with the diagnosis of arterial hypertension of stage II risk III, who have been taking Perindopril, Telmisartan and Bisoprolol for3 months. The control of arterial pressure level, biochemical analysis of metabolic indices and morning urine portion test for microalbuminuria has been carried out. Results. MAU has been revealed in 17,6% patients, occurring more frequently in men than in women. Microalbuminuria is accompanied by reliable decrease of total and ionized calcium and magnesium concentrations, an increase of potassium level in blood plasma, increase of cholesterol, triglycerides, glucose and levels. Patients with AH and renal dysfunction reliably demonstrate higher levels of systolic and diastolic arterial pressure in the morning and evening hours, their normalization effect after APs intake is significantly interconnected with MAU presence. Conclusion. In patients with AH and MAU the main risk factors of cardio-vascular diseases development are more expressed. Microalbuminuria is a risk factor in patients with arterial hypertension and may influence on the basic blood electrolyte balance. While carrying out antihypertensive therapy the presence of MAU should be taken into consideration

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Pharmacodynamic and pharmacoeconomic aspects of application of antihypertensive preparations of various groups in patients with arterial hypertension

Year: 2010, volume 6 Issue: №3 Pages: 504-510
Heading: Clinical Pharmacology Article type: Original article
Authors: Kurkina T.V., Svistunov А.А., Bogoslovskaya S.I., Klochkov V.A., Glybochko G.H., Shuldyakov V.A., Luchinina EM., Levanov A.N.
Organization: Saratov State Medical University, Saratov Regional Hospital for Veterans of Wars, Saratov Institute of Cardiology, Russia
Summary:

At the background of the therapy for 3 months with Perindopril, Telmisartan and Bisoprolol, the patients with arterial hypertension were noted to decrease systolic and diastolic arterial pressure. The preparations under investigation had different effects on electrolyte metabolism. Therapy with Telmisartan turned out to have the least effect on electrolyte metabolism. Microalbuminuria is a risk factor in patients with arterial hypertension and may influence on the basic blood electrolyte balance. Bisoprolol should be recommended as the most preferable therapy for arterial hypertension from the pharmacoeconomic point of view. In order to control morning systolic arterial pressure the preference should be given to Perindopril, while for controlling evening systolic arterial pressure the preference should be given to Telmisartan

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Оptimization of pharmacotherapy of osteopenia in children with chronic pyelonephritis

Year: 2010, volume 6 Issue: №1 Pages: 043-045
Heading: Clinical Pharmacology Article type: Original article
Authors: L.A. Osipova, S.I. Bogoslovskaya, T.V. Shelehova, N.E. Nikiforova
Organization: Saratov State Medical University, Saratov Regional Children Clinical Hospital
Summary:

The purpose of present research wras definition of frequency of osteopenia development in children with chronic pyelonephritis and optimization of pharmacological correction of revealed disorders. 121 children with chronic pyelonephritis and normal glomerular filtration rate were included in the investigation. Mineral density of bone tissue, biochemical parameters of bone remodeling, cytokine profiles were examined. 3 varients of therapy were used. Control period lasted 12 months. Clinical predictors of osteopenia were indicated. The increased biochemical parameters of bone resorption, IL-6, IL-4, OPG were revealed in chidren with chronic pyelonephritis, the indices were higher in case of osteopenia. The article concluded that the most effective treatment scheme included the use of 3 medicines with different effects

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Investigation Of Arterial Blood Pressure Level And Metabolic Indices In Patients With Arterial Hypertension At Pharmacotherapy With Antihypertensive Medicines Of Various Chemical Structure

Year: 2009, volume 5 Issue: №4 Pages: 500-505
Heading: Clinical Pharmacology Article type: Original article
Authors: T.V. Kurkina, A.A. Svistunov, S.I. Bogoslovskaya, V.A. Klochkov, E.V. Luchinina, G.Kh. Glybochko
Organization: Saratov Institute of Cardiology, Russia, Saratov State Medical University
Summary:

The research goal is to carry on the comparative analysis of medicines of various chemical structure, Telmisar-tan and Bisoprolol, and to reveal their effect on the arterial blood pressure level and the indices of various metabolic processes in patients with arterial hypertension. 60 out-patients with arterial hypertension (stage II risk III) both males and females aged 33-55 have been under study taking Telmisartan and Bisoprolol for 3 months. While treating the patients the arterial blood pressure level control and biochemical investigations for determination the indices of metabolic processes have been carried out. The investigated medications have provided the decrease of systolic and diastolic arterial pressure parameters, the increase of concentration of total and ionized calcium, chlorine ions, urea and total bilirubin in blood plasma. Therapy with Telmisartan has shown more significant increase of potassium level in erythro-cytes, decrease of levels of natrium, glucose, glycolized hemoglobin and triglycerides and increased contents of alani-naminotransferase and aspartataminotransferase. The course of therapy with Bisoprolol has restored the normal level of magnesium in blood plasma, has not have any influence on carbohydrate and lipid metabolism, increased the level of alaninaminotransferase and significantly increased the contents of total and ionized calcium, urea and creatinine. 3-months therapy with Telmisartan and Bisoprolol has proved the decrease of systolic and diastolic arterial pressure in patients with arterial hypertension. The medications under study have had active and variable effects on metabolic indices

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BETA-ADRENORECEPTORS GENETIC POLYMORPHISM CONNECTION WITH BETA-BLOKER THERAPY EFFICACY IN PATIENTS WITH CARDIOVASCULAR DISORDERS

Year: 2009, volume 5 Issue: №1 Pages: 41-44
Heading: Clinical Pharmacology Article type: Original article
Authors: A.N. Levanov, I.V. Ignatyev, D.A. Sychev, S.I. Bogoslovskaya, A.A. Svistunov
Organization: Saratov State Medical University, First Moscow State Medical University n.a. I.M. Sechenov, Institute of Clinical Pharmacology
Summary:

At present it is obvious that genetic peculiarities of patients are the major reason for individual differences in pharmacological responses to (?-adrenoblockers. Furthermore ADRB1 gene polymorphism is responsible for the efficiency of (?-adrenoblockers. Thus, a real prospect exists for an individualized approach to administration of (?-adrenoblockers and selection of dosage based on patient’s genotype, which must undoubtedly increase efficiency of the administered therapy. Reviewfocuses on gene polymorphism responsible for (?-adrenoblockers pharmacodynamics and on the clinical significance of the polymorphism detection to individualize drug therapy based on patient’s genotype.

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