Saratov JOURNAL of Medical and Scientific Research

Clinical Perinatal Center of the Saratov Region

Congenital megakaryoblastic leukemia: A clinical case

Year: 2019, volume 15 Issue: №1 Pages: 34-40
Heading: Pediatrics Article type: Case report
Authors: Nechaev V.N., Chernenkov Yu.V., Mishina O.A., Fedorova Yu.A., Averyanov A.P.
Organization: Clinical Perinatal Center of the Saratov Region, Saratov State Medical University
Summary:

Leukemia in children (leukemia) is a systemic hemoblastosis, accompanied by a violation of bone marrow hemato- poiesis and replacement of normal blood cells with immature blast cells of the leukocyte series. Acute megakaryoblastic leukemia-one of the rarest forms of acute leukemia (1-3% of all leukaemias), which is characterized by the presence in the blood and bone marrow, along with undifferentiated blasts also megakaryoblasts, ugly megakaryocytes and platelet clusters. The work presents a clinical case of congenital acute megakaryoblastic leukemia in the child S., combined with the mosaic form of Down syndrome and a congenital heart defect.

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