Saratov JOURNAL of Medical and Scientific Research

The S. Fyodorov Eye Microsurgery Federal State Institution

Bacterial collagenase in the treatment of vitreoretinal pathology

Year: 2018, volume 14 Issue: №4 Pages: 953-956
Heading: Ophtalmology Article type: Review
Authors: Zgoba M.l., Lyskin P.V., Makarenko I.R.
Organization: The S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Bacterial collagenase has been used in Russian ophthalmology for more than 40 years, its official medical use is allowed since 1983 Collagenase is used in the treatment of a broad spectrum of ophthalmopathology For the treatment of vitreoretinal pathology the drug has been used since 1996 To date, quite a lot of experience in the use of bacterial collagenase for the treatment of vitreoretinal pathology has been accumulated. The article presents the literature data on the possibilities of using the drug in various areas of vitreoretinal pathology and the prospects of expanding the indications for the use of the drug in a wider ophthalmic practice.

AttachmentSize
2018_4-2_953-956_1.pdf267.8 KB

Bacterial collagenase in the treatment of vitreoretinal pathology

Year: 2018, volume 14 Issue: №4 Pages: 953-956
Heading: Ophtalmology Article type: Review
Authors: Zgoba M.l., Lyskin P.V., Makarenko I.R.
Organization: The S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Bacterial collagenase has been used in Russian ophthalmology for more than 40 years, its official medical use is allowed since 1983 Collagenase is used in the treatment of a broad spectrum of ophthalmopathology For the treatment of vitreoretinal pathology the drug has been used since 1996 To date, quite a lot of experience in the use of bacterial collagenase for the treatment of vitreoretinal pathology has been accumulated. The article presents the literature data on the possibilities of using the drug in various areas of vitreoretinal pathology and the prospects of expanding the indications for the use of the drug in a wider ophthalmic practice.

AttachmentSize
2018_4-2_953-956_1.pdf267.8 KB

Comparison of uveal melanoma molecular classification systems

Year: 2018, volume 14 Issue: №4 Pages: 898-890
Heading: Ophtalmology Article type: Original article
Authors: Yarovoy А.А., Yarovaya V.A., Chudakova L.V., Chochaeva A.M., Loginov R.A., Kleyankina S.S., Zaretsky A.R.
Organization: Evrogen Laboratory LLC, The S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Purpose: to compare cytogenetic and mutational classifications of uveal melanoma (UM) in comprehensive analysis. Material and Methods. UM tissue from 154 eyes treated by enucleation or eye-sparing treatment was analyzed. Analysis included FISH for monosomy 3 and 8q gain, PCR for GNAQ, GNA11, EIF1AX and SF3B1 mutations and immunohistochemistry for BAP1. The group of 66 patients was used to compare cytogenetic and mutational classifications of uveal melanoma. Results. Discrepancy between cytogenetic and mutational classifications was revealed in 79% of cases. Unusual combination of EIF1 AX mutation with monosomy 3 or BAP1 inactivation was seen. Conclusion. Prognostic significance of the discrepancy between the two UM classifications is currently unknown. Further research is needed.

AttachmentSize
2018_4-2_898-900.pdf256.23 KB

Results of combined treatment of iris cysts

Year: 2018, volume 14 Issue: №4 Pages: 891-894
Heading: Ophtalmology Article type: Original article
Authors: Yarovoy А.А., Bulgakova E.S., Yarovaya V.A., Chochaeva A.M., Korobov E.N.
Organization: The S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Purpose. To present the own experience in iris cyst treatment. Materials and Methods. In this retrospective study 20 eyes with iris cysts were included. Lesions were managed with intracystic ethanol irrigation with and without subsequent surgical resection of the walls. Results. Complete iris cyst destruction was achieved in 16 cases. In 4 eyes cyst recurrence after ethanol irrigation was revealed and successfully treated by ethanol irrigation without subsequent surgical resection of the walls. No complications were seen within mean follow-up of 26 months. Conclusion. Intracystic ethanol irrigation is an effective treatment modality. Additional surgical resection of the cyst walls helps to improve treatment results with no signs of recurrences and complications.

Surgical treatment of rhegmatogenous retinal detachment with inferior breaks using gas tamponade of the vitreal cavity

Year: 2018, volume 14 Issue: №4 Pages: 870-872
Heading: Ophtalmology Article type: Short message
Authors: Shkvorchenko D.O., Gorshkov I.M., Yukhananova A.V, Khurdaeva A.G.
Organization: The S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Purpose: to evaluate the efficacy of tamponade of a vitreous cavity with gas-air mixture in patients with rhegmatogenous retinal detachment (RRD) in the lower hemisphere. Materials and Methods. We examined and operated on 52 patients with RRD with the localization of the discontinuities in the lower hemisphere: 30 patients with RRD with involvement of macula and 22 patients with RRD without macular involvement. All patients underwent general and special ophthalmological examination. Standard surgical treatment of retinal detachment finalized with injection of gas-air mixture into the vitreal cavity was performed. Results. In all cases, patients with RRD without involvement of macula and in 27 cases of RRD with involvement of macula there was a full adherence of the retina. In 3 cases patients with RRD involving the macula underwent repeat surgery with tamponade of the vitreous cavity with silicone, after which the retina adherence was finally observed. Close relationship between the improvement of visual acuity in patients 6 months after the operation and reduction in retinal thickness. Conclusion. The obtained results demonstrate the possibility of using gas tamponade of the vitreous cavity in RRD surgery with localization of rupture in the lower hemisphere.

AttachmentSize
2018_4-2_870-872.pdf254.92 KB

Surgical treatment of regmatogenous retinal detachment complicated by macular hole using platelet-rich blood plasma and local staining

Year: 2018, volume 14 Issue: №4 Pages: 867-870
Heading: Ophtalmology Article type: Original article
Authors: Zaharov V.D., Shkvorchenko D.O., Krupina E.A., Kakunina S.A., Norman K.S., Khurdaeva A.G., Yukhananova A.V.
Organization: The S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Purpose: to study the effectiveness of surgical treatment of regmatogenous retinal detachment (ROS) complicated by macular hole (MH) using platelet-rich blood plasma (PRP). Material and Methods. The study included 27 patients (27 eyes) with a diagnosis of ROS complicated by MH. In each case, the technique was used, namely, that after performing vitrectomy, a perfluororganic compound (PFOS) was injected into the hole area with a diameter of 2-3 diameter of the disk, to prevent penetration of dye under the retina, stained and removed internal limiting membrane (ILM). After serial PFOS/air replacement at the gap introduced PRP. The operation was completed with the introduction of silicone oil (CM). CM was removed from the vitreous cavity after 2 months. The follow-up period is 12 months. Results. In all cases, it was possible to achieve the adhesion of the retina and block Mr. During the observation period visual acuity increased to 0.1-0.9. Conclusion. According to the evaluation of the results, surgical treatment of regmatogenous retinal detachment complicated by MH using PRP is an effective method of treatment.

AttachmentSize
2018_4-2_867-870.pdf451.46 KB

Surgical treatment of regmatogenous retinal detachment complicated by macular hole using platelet-rich blood plasma and local staining

Year: 2018, volume 14 Issue: №4 Pages: 867-870
Heading: Ophtalmology Article type: Original article
Authors: Zaharov V.D., Shkvorchenko D.O., Krupina E.A., Kakunina S.A., Norman K.S., Khurdaeva A.G., Yukhananova A.V.
Organization: The S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Purpose: to study the effectiveness of surgical treatment of regmatogenous retinal detachment (ROS) complicated by macular hole (MH) using platelet-rich blood plasma (PRP). Material and Methods. The study included 27 patients (27 eyes) with a diagnosis of ROS complicated by MH. In each case, the technique was used, namely, that after performing vitrectomy, a perfluororganic compound (PFOS) was injected into the hole area with a diameter of 2-3 diameter of the disk, to prevent penetration of dye under the retina, stained and removed internal limiting membrane (ILM). After serial PFOS/air replacement at the gap introduced PRP. The operation was completed with the introduction of silicone oil (CM). CM was removed from the vitreous cavity after 2 months. The follow-up period is 12 months. Results. In all cases, it was possible to achieve the adhesion of the retina and block Mr. During the observation period visual acuity increased to 0.1-0.9. Conclusion. According to the evaluation of the results, surgical treatment of regmatogenous retinal detachment complicated by MH using PRP is an effective method of treatment.

AttachmentSize
2018_4-2_867-870.pdf451.46 KB

Microinvasive non-surgical treatment of vitreomacular traction

Year: 2018, volume 14 Issue: №4 Pages: 846-849
Heading: Ophtalmology Article type: Original article
Authors: Lyskin P.V., Zakharov V.D., Shpak А.А., Zgoba M.l.
Organization: The S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Purpose: evaluation of the effectiveness of treatment for vitreomacular traction below 500 urn in length uncomplicated by epiretinal fibrosis and macular holes. Material and Methods. Enzymatic vitreolysis was used to treat 23 patients (23 eyes) with uncomplicated vitreomacular traction up to 500 urn in length. Results. Elimination of vitreomacular traction was achieved in 17 cases (74%). The goal of intervention was not achieved in 5 cases (21 %), in 1 case (5%) a macular hole was formed. Conclusion. The results have shown that enzymatic vitreolysis can be a method of choice for treatment of vitreomacular traction up to 500 urn uncomplicated by epiretinal fibrosis and macular holes.

AttachmentSize
2018_4-2_846-849.pdf1.84 MB