Saratov JOURNAL of Medical and Scientific Research

osteoporosis

Techniques of augmentation and full-endoscopic decompression in the treatment of patients with vertebral fractures of osteoporotic origin

Year: 2018, volume 14 Issue: №3 Pages: 412-416
Heading: neurosurgery Article type: Case report
Authors: Kravtsov M.N., Mirzametov S.D., Svistov D.V.
Organization: Military Medical Academy n.a. S. M. Kirov
Summary:

The article highlights debatable questions concerning the effectiveness of surgical treatment of osteoporotic vertebral fractures. The reasons of unsuccessful outcomes of vertebroplasty are analyzed. A combined method of surgical treatment is proposed, including vertebroplasty and full-endoscopic foraminotomy with a combination of local and ra-dicular pain syndrome caused by stenosis of the intervertebral foramen. A clinical example is given.

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Treatment of chronic generalized periodontitis at women in the period of postmenopause

Year: 2015, volume 11 Issue: №1 Pages: 069-073
Heading: Stomatology Article type: Original article
Authors: Ostrovskaya L.U., Khanina A.l.
Organization: Saratov State Medical University
Summary:

Purpose: an assessment of efficiency of complex treatment of periodontitis at women in a period of postmenopause with the use of zoledronic acid. Material and methods. Examination and treatment of 90 patients with a chronic generalized periodontitis against post-menopausal osteoporosis has been conducted. Material is processed statistically. Results. Application of preparations of zoledronic acid in complex treatment of system osteoporosis and periodontitis allows to reduce the frequency of recurrence of periodontal disease and to improve indicators of bone remodeling. Conclusion. In conclusion it is worth while determining that zoledronic acid in complex therapy of periodontitis is an effective method of drug correction of a mineral exchange before periodontological surgery.

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Pharmaco-therapy optimization of osteoporosis and osteopenic syndrome in patients with vibratory disease of common and local impact

Year: 2013, volume 9 Issue: №1 Pages: 34-38
Heading: Clinical Pharmacology Article type: Original article
Authors: Aleshechkina Е.Е., Shelekhova T.V., Bogoslovskaya S. I., Zaitseva M.R., Nikiforova N.E., Zhilyakov A.N.
Organization: Saratov State Medical University
Summary:

Vibratory disease is one of the leading pathologies in the field of professional diseases, Polymorphism of manifestation is its peculiarity, including disorders of bone remodelling process. The goal of this study was to define peculiarity of bone interchange in patients with vibratory disease of common and local impact. Material and methods. 272 patients took part in the research; they were subjected to determination of mineral density level of bone tissue, markers of osteosis and bone resorption and cytokine profile. Three variants of treatment were used in the period of 12 months. Results. Positive dynamics of ultrasonic densitometry indices, osteogenesis markers (ionized calcium, alkaline phos-phatase), osteoprotogerine in sub-groups with vibrating disease treated with calcium medication and vitamin D was revealed. Conclusion. Research of mineral density of bone tissue and markers of bone remodelling is necessary for prescription a pathogenetic therapy at osteoporosis and osteopenic syndrome in patients with vibrating disease from general to local impact.

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Surgery of vertebral bodies compressive fractures according to results of algorithm of osteoporosis radial diagnostics

Year: 2011, volume 7 Issue: №4 Pages: 930-933
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Tomilov А.В., Eidlina Е.М., Kuznetsova N.L.
Organization: Uralsk Scientific Research Institute of Traumatology and Orthopedics n. a. V.D. Chaklin
Summary:

The research goal is to optimize the algorithm of radial methods of investigation of early vertebral osteoporosis and vertebral compressive fractures in case of osteoporosis, as well as surgical tactics in vertebral compressive fractures, aggravated by osteoporosis. 220 postmenopausal women have been examined. 100 patients with compressive vertebral fractures and 120 patients without risk factors of compressive fractures were under study. 220 patients have received lateral spinal radiography and dual-energy X-ray absorptiometry. 60 patients with compressive vertebral fractures have been examined by quantitative computed tomography. Compressive fractures have been diagnosed in 20 men who suffered from osteoporosis. Statistical processing of received data has been performed. It has been concluded that the use of quantitative computed tomography has made possible to identify the reduction in bone mineralization with an increase in age of patients. When the difficulties in interpretation of clinical data and X-ray densitometry findings have been determined, quantitative computed tomography has occurred to be the method of choice. Quantitative computed tomography helps determine the degree of resorption of trabecular bone in vertebral bodies and prognose high risk of fractures. Surgeries have been performed in presence of osteoporosis which does not affect the stability of the structure.

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Clinical features and some mechanisms of formation of inflammatoty periodontal diseases at women in the postmenopausal period

Year: 2011, volume 7 Issue: №1 Pages: 318-319
Heading: Stomatology Article type: Short message
Authors: Ostrovskaya L.U., Chanina A.I.
Organization: Saratov State Medical University
Summary:

For the purpose to determine clinical morphologic features of development of inflammatoty periodontal diseases at women in the postmenopausal period medical examination of 90 patients was carried out. It was established that a postmenopausal osteoporosis is risk factor of development periodontal diseases. In formation of periodontal diseases at women during this period the important role is played hormonal changes

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Osteoporosis in Saratov Region: Dissemintation and Prevention

Year: 2010, volume 6 Issue: №2 Pages: 414-419
Heading: Traumatology and Orthopedics Article type: Review
Authors: G.A. Bluvshtein N.V. Chupakhin V.A. Shuldyacov T.A. Knyazkova
Organization: Saratov State Medical University, Saratov Regional Hospital for Veterans of Wars
Summary:

From 1996 to 2008, the population in Saratov region decreased by 5.6%. From 2006 to 2008, injury indices in the region increased by 4.88%: fractures of thoracic and inferior limbs were caused by osteoporosis, taking into account «population aging». To decrease injury and fracture rates among the population of Saratov region is necessary to raise osteoporosis detection

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Condition Of Lithogenesis Processes In Kidneys Secondary To Androgynous Therapies Lithogenesis Processes In Kidneys At Receiving Androgynous Therapy

Year: 2009, volume 5 Issue: №4 Pages: 612-615
Heading: Urology Article type: Original article
Authors: P.I. Shuster, P.V. Glybochko
Organization: Saratov State Medical University, Omsk State Medical Academy
Summary:

Research objective is to study processes of lithogenesis at patients with considerably cured urolithiasis at androg-enous therapy. The patients observed in urological clinic of Omsk State Medical Academy have been included. By means of method «case-control» 2 groups have been formed : the basic group - 10 patients with considerably cured urolithiasis and with hypogonadism receiving androgenous therapy and the comparison group - 10 patients with considerably cured urolithiasis and with hypogonadism without receiving androgenous therapy. Processes of lithogenesis at patients who received androgenous therapy have proceeded statistically significantly in comparison with patients without receiving androgenous therapy. It has been proved that there is a negative influence of testosterone deficiency on processes of lithogenesis. The obtained data demonstrate that lithogenic processes at patients with hypogonadism are more expressed and lead to more frequent urolithiasis recurrence. Noninvasiveness, technical simplicity and availability of method «Litos-test» provides its use for express-screening method for inspection of the population and for estimation of antireccurent efficiency of androgen replacement therapy at men with urolithiasis

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Etiopathogenic correlations between age-specific hypogonadism, osteoporosis and urolithiasis at men

Year: 2009, volume 5 Issue: №4 Pages: 604-607
Heading: Urology Article type: Original article
Authors: P.V. Glybochko, P.I. Shuster
Organization: Saratov State Medical University, Omsk State Medical Academy
Summary:

Study of age-specific hypogonadism correlation through osteopenia with urolithiasis at men is a new perspective direction uniting endocrinology and somatic urology. Besides comparison groups patients observed in the urological clinic of Omsk State Medical Academy have been included in one-stage continuous research. The method of stratification has allowed distinguishing two groups: group of men with urolithiasis - 140 patients and comparison group - 30 men without urolithiasis. Research methods have included questioning of patients by means of questionnaire AMS and international erectile function index, estimation of body weight index, biochemical indicators of blood serum, general testosterone, ionized calcium, densitometry. Occurrence of hypogonadism at men with urolithiasis has accounted 57,1 % (80 patients), in comparison group (men without urolithiasis) it has accounted 23,3 % (7 patients). Occurrence of decrease in mineral density of bone tissue has been statistically and significantly higher at patients with hypogonadism that proves interrelation of osteo-calcium metabolism disturbances and urolithiasis development. The 1st group has accounted 8,7 % of patients with osteoporosis, the 2nd group - 3,3 %. The 1st group has accounted 70,0% of patients with osteopenia, the 2nd group - 25,0%. Level of testosterone is associated with degree of expressiveness of decrease in mineral density of bone tissue. The lowest indices of testosterone have been at men with osteoporosis. Revealed correlations have shown adverse influence of hypogonadism not only on the sexual status of patient, but also on condition of osteo-calcium metabolism, disturbances of which may cause urolithiasis

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Immunological Indices At Gerontological Patients With Ischemic Heart Disease, Metabolic Disturbances And Osteoporosis

Summary:

Gerontological patients with ischemic heart disease which is not accompanied by such pathology as diabetes (SD) and osteoporosis (OP) with normal or increased body weight (females) generally have got «the highest potential of health». It has been proved by phase portraits and autoantibodies (AAb) and cytokines indices. Adaptative disturbances in these groups have been revealed at the age of 95 and 89 accordingly. The presence of such accompanying pathology as SD and OP causes dysadaptation. It is evident by means of autoantibodies (AAb) and cytokines indices and phase portraits of «temporary dependence of general cholesterol levels - its first derivative»

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Efficiency and safety of androgenic therapies of hypogonadism at patients with considerably eliminated urolithiasis

Year: 2009, volume 5 Issue: №3 Pages: 327-332
Heading: Urology Article type: Original article
Authors: P.I. Shuster
Organization: Omsk State Medical Academy
Summary:

The weakest unit in treatment of urolithiasis is revealing in each specific case etiological factor of lithogenic and carrying out etiotropic therapy, and, hence prevention of urolithiasis relapse. The study of correlation of hypogonadism through osteosinging with urolithiasis at men is the new perspective direction uniting Endocrinology and somatic Urology.
In prospective cohort research the patients divided into 2 groups have been included: basic group - patients with considerably cured urolithiasis and hypogonadism, received androgenic therapy (30 persons); comparison group -patients with considerably cured urolithiasis and hypogonadism, not receiving androgen therapy (30 persons).
Used: questioning on questionnaire AMS, the International index of erectile functions (IIEF-5), index of weight of a body, haemoglobin, hematocrit, biochemical indicators of blood serum, densitometry, general testosterone, PSA, and ionized calcium.
After contra-indications exception (cancer of prostate gland, expressed increase of haemoglobin and hematocrit) the basic group patients were prescribed one of testosterone group drug during the period not less than 6 months: Androgel (Solvay Pharma), Nebido (Bayer Schering Pharma), Sustanon-250 (Organon), Omnadren-250 (Polfa).
At the moment of the therapy beginning, patients of both groups were comparable in all investigated indices.
Relapse of urolithiasis: against androgenic therapy - 28,6%, in comparison group - 63,2%. The obtained data testify to efficiency of androgenic therapy in respect to prevention of urolithiasis at patients with hypogonadism and confirm the role of hypogonadism as one of etiopathogenetic development factors of urolithiasis.
Androgenic therapy was safe. All patients had insignificant increase of general PSA level and statistically significant increase of haemoglobin and hematocrit indicators. However, the received changes did not demand cancellation, or therapy correction.

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