Saratov JOURNAL of Medical and Scientific Research

Infectious Diseases

Epizootic Situation at Rabies in Saratov Region

Year: 2011, volume 7 Issue: №4 Pages: 860-862
Heading: Infectious Diseases Article type: Original article
Authors: Eryomin V.I., Zayats N.A., Narkaytis L.I., Lavrentiev M.V., Krasilnikova N.N.
Organization: Saratov State Medical University, Administration of Federal Agency for Supervision in the Sphere of Consumers Rights Protection and Human Well-being in Saratov region
Summary:

The purpose of the study was to investigate epizootic situation at rabies in Saratov region during the period from 2000 to 2010. Materials and methods. Retrospective analysis of rabies morbidity of wild and farm animals was conducted. Results. During the reporting period an increase of animals' morbidity, accompanied by extension of unfavorable settlements in case of this disease was marked. Annual rate of diseased animals is defined by seasonal activity changes of foxes. The main carriers of rabies virus in the region are foxes. Conclusion. Epizootic situation at rabies in Saratov region is evaluated as unfavorable

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Peculiarities of infectious diseases course accompanied by quinsy syndrome in children (data from children infectious hospital)

Year: 2011, volume 7 Issue: №1 Pages: 103-106
Heading: Infectious Diseases Article type: Original article
Authors: Borisova O.V., Gasilina E.S., Santalova G.V., Mitrofanov AM, Ovchinnikova T.A.
Organization: Samara State Medical University
Summary:

The research goal is to study morbidity dynamics for the period of 15 years and to determine clinical signs that accompany quinsy syndrome (diphtheria, infectious mononucleosis, scarlet fever, quinsy). Retrospective study analysis of annual reports and case-histories was carried out. 323 cases of infectious diseases accompanied by quinsy syndrome were examined. Clinical and epidemic signs of diseases were determined during the period of morbidity raise. The current clinical course of diseases was characterized in detail. The significant percentage of renal complications in case of pharyngonasal cavity lesion was shown

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Etiological structure of bacterial meningitis in children

Year: 2010, volume 6 Issue: №4 Pages: 780-782
Heading: Infectious Diseases Article type: Original article
Authors: K.A. Jafarova
Organization: Azerbaijan Medical University
Summary:

The microbiological investigation of 14 year old children with meningeal and infectious syndromes was held. Bacterial meningitis was diagnosed in 90,9% patients. The meningococcal meningitis was diagnosed in 18 (30%) patients, H. influenzae meningitis - in 9 (15%), S. pneumoniae - in 8 (13,3%). Meningitis as a monoinfection was revealed in 85% cases; mixed infection - in 15%. In 28 patients the etiologic agents of disease were gram-negative, in 16 children -gram-positive bacteria. Causative agents of bacterial meningitis were more resistant to penicillin, ampicillin and eritromycin

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Epstein-Barr virus mononucleosis: clinical and dynamic peculiarities of different variants of infection

Year: 2010, volume 6 Issue: №3 Pages: 570-574
Heading: Infectious Diseases Article type: Original article
Authors: Khmilevskaya S.A
Organization: Saratov State Medical University
Summary:

The article reviews the results of observation of 439 patients between 1 and 18 years of age with EBV mononucleosis. The detailed analysis of clinical laboratory peculiarities of primary infection and its reactivation in patients of different age is also supplemented by the overall evaluation of the rehabilitation period in dependence on age and type of infection.

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Immunological and morphological aspects of diagnostics of Helicobacter pylori infection and Herpesviridae viruses

Year: 2010, volume 6 Issue: №2 Pages: 360-364
Heading: Infectious Diseases Article type: Original article
Authors: N.G. Dudaeva, V.B. Grechushnikov, I.O. Bugaeva, G.N. Tarasova, T.V. Golovacheva
Organization: Saratov State Medical University, Rostov State Medical University, Moscow Central Hospital № 6, Head of Endoscopic Ward
Summary:

100 patients with inflammatory diseases of gastrointestinal tract were examined. Microbial component of inflammation process was detected by means of polymerase chain reaction (PCR). By means of PCR etiological microbial factor of mononuclear cells in peripheral blood (MCPB) was investigated. Mixtinfication of mucosa membrane of gastrointestinal tract with H. pylori and Herpesviridae in pathology of gastroduodenal area and presence of fragments of microorganisms DNA in PBMC were revealed. This phenomenon may be important in pathogenesis of pathology of gastrointestinal tract and forms the basis for its further investigation

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Occupational risk of HIV infection among dental surgeons in Nigerian

Year: 2010, volume 6 Issue: №2 Pages: 357-360
Heading: Infectious Diseases Article type: Original article
Authors: C.C. Azodo
Organization: Nigeria, University of Benin Teaching Hospital
Summary:

Background: Prevention of accidents and management of exposures in the work environment is an important oc¬cupation health issue. This study objective was to investigate the occupational risk of HIV among Nigerian dental sur¬geons. Methods: This descriptive cross sectional survey of 300 dental surgeons practicing in private and government owned dental centers in Nigeria was conducted from June 2006 to January 2007. Results: Percutaneous injury was recorded among 69.3% of respondents and only 1.2% had Post exposure prophylaxis. Those with abraded skin that will treat patient without additional barrier were 8.6%. Percutaneous injury was positively related to gender, position, additional qualifications (p<0.05). Conclusion: Percutaneous injury is significantly high and low preventive measure at such exposure. Policies, practices, and trainings geared towards protecting and reducing the prevalence of percu¬taneous injury among dental surgeons, and improving post exposure prophylaxis uptake in the event of exposure is a necessity

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Tegument based in-silico Drug Targeting of Herpes Simplex Virus-1

Year: 2010, volume 6 Issue: №2 Pages: 353-357
Heading: Infectious Diseases Article type: Original article
Authors: Ashish Runthala, Amit Kumar Singh
Organization: India, Pilani, Birla Institute of Technology & Science, Biological Sciences Department, India, Gurgaon
Summary:

Alpha Trans Inducing Factor (a-TIF) is a herpes simplex virus type 1 (HSV-1) virion tegument protein present in the tegument layer between the capsid and the envelope, in association with cellular proteins and trans-activated viral activities. a-TIF stimulates the transcription of HSV-1 Immediate Early genes during lytic virus replication. The presence or absence of functional a-TIF protein in vivo is always associated with viral activities. Its role behind latent HSV-1 infection is ambiguous. No drug is designed for HSV till now based on this protein and thus its conformational details can be very important for drug designing purpose. Methods. Docking studies on this protein becomes logical. Four different ligand molecules viz. Adenosine-3'-5'-Diphosphate, P1-(5'-Adenosyl) P4-(5'-(2'-Deoxy-Thymidyl)) Tet-raphosphate, 9-Hydroxymethylguanine, 9-(4-Hydroxybutyl)-N2-Phenylguanine were screened for the study. Results. P1-(5'-Adenosyl) P4-(5'-(2'-Deoxy-Thymidyl) Tetraphophate was found to be the best ligand as it showed the lowest docking energy of - 9.238 kcal/mol. Conclusions. The best ligand was found to bind different sites of the a-TIF protein and hence can be utilized to combat HSV-1 successfully, with a synergistic effect of multiplicity of drug molecules on the target protein

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Variability Of Heart Rate In Patients With Chronic Brucellosis: Peculiarities Of Vegetative Regulation

Year: 2009, volume 5 Issue: №4 Pages: 578-580
Heading: Infectious Diseases Article type: Short message
Authors: А.А. Reshetnikov, A.A. Shuldyakov, M.V. Safonova
Organization: Saratov State Medical University, Saratov City Clinical Hospital № 2
Summary:

The research goal is to study vegetative regulation of heart rate in patients with chronic brucellosis of various clinical forms and activity degrees. 80 patients with chronic brucellosis have been examined. Predominant influence of sympathetic part of vegetative nervous system on regulation of heart rate in active form of chronic brucellosis and influence of parasympathetic part in inactive form have been revealed. Character of vegetative dysfunction depends on clinical form of the disease only in the case of active chronic brucellosis

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Liver Functional State Changes At Epstein-Barr Virus Mononucleou-sis In Children

Year: 2009, volume 5 Issue: №4 Pages: 572-577
Heading: Infectious Diseases Article type: Original article
Authors: S.A. Khmilevskaya, LA. Zaytseva, E. V. Mikhailova
Organization: Saratov State Medical University
Summary:

The research presents the results of medical observation of 439 patients aged 1-18 with mononucleosis of Epstein-Barr Virus etiology. By means of instrumental and clinical laboratory methods of investigation the peculiarities of liver condition have been revealed in children of different age. The intensity of autosensibilization processes to the tissues of the organ has also been estimated. The results obtained demonstrate the interrelation of clinical, biochemical and instrumental signs of liver damage, as well as contribution of autoimmune processes to the development of organopa-thology at Epstein-Barr Virus infection

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THE STATE OF THE PROBLEM OF DIAGNOSTICS AND TREATMENT OF ELECTROTHERMAL BURNS IN SAMARA REGION

Year: 2008, volume 4 Issue: №4 Pages: 112-115
Heading: Infectious Diseases Article type: Original article
Authors: A. V. Tolstov
Organization: Samara State Medical University
Summary:

With the purpose of the improvement of results of patients' treatment in case of electrothermal burns the analysis has been carried out for the period of 11 years. Thus 235 patients have been admitted to the hospital with electrical injury over this time span. Frequencyofelectrothermal burns acounts for 1,25% up to 2,5 % per one year. 119 children constitute 50,6 % of all patients. Lethality among the patients with electrical injuries acounts for 2,5%. Generalized infection in the form of sepsis and bacteremia can be revealed in 13,6 %of all patients. The proper classification of electrotrauma has been worked out

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