Saratov JOURNAL of Medical and Scientific Research

Infectious Diseases

Efficacy of cikloferon liniment in complex therapy of secondary herpes associated with psoriasis

Year: 2013, volume 9 Issue: №2 Pages: 197-200
Heading: Infectious Diseases Article type: Original article
Authors: Shuldyakov A.A., Barchatova Т.S, Lisko О.В., Satarova S.A., Perminova Т.A., Tsareva T.D.
Organization: Saratov State Medical University
Summary:

The aim of the study: Modification in the treatment of patients with herpes associated with psoriasis. Materials and methods: 30 patients were included in the study divided into two groups. In the 1st group the patients received standard treatment for herpes and two daily applications of cikloferon liniment for seven days. In the 2nd group the patients received only standard treatment for herpes. The patients were followed-up for six months. The study was open-label randomized. Results: The results obtained show that general infectious symptoms of herpes subsided considerably faster in the 1st group of patients treated with cikloferon liniment. The applications with the topical immunomodulator enhanced more dynamic disappearance of erosions. During the six months follow-up exacerbations of herpes were noted in 10% of patients in the 1st group and in 30% of patients in the second group. Cikloferon liniment was well tolerated and no side effects were noted. Conclusion: Cikloferon liniment used for the treatment of patients with herpes exacerbation associated with psoriasis contributes to more dynamic disappearance of infectious syndrome, enhances epithelization of herpetic erosions, and lowers the duration of erosions and local inflammation as well as the number of exacerbations in catamnesis.

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National calendar of preventive vaccination: problems, solutions and results in Saratov region

Year: 2013, volume 9 Issue: №2 Pages: 192-196
Heading: Infectious Diseases Article type: Review
Authors: Uchaikin V.F., Shamsheva O.V., Mikhailova ЕМ., Shvedova N.M
Organization: Saratov State Medical University, Russian State Medical University
Summary:

National immunization calendar of Russia includes 11 entities that are carried out against the mass vaccination of children. And at the present time there is a high incidence of tuberculosis, whooping cough, measles incidence is increasing. In the article the causes have been analyzed, some possible solutions have been drawn.

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Клинико-эпидемиологическая характеристика гриппа в постпандемический период

Year: 2013, volume 9 Issue: №2 Pages: 186-192
Heading: Infectious Diseases Article type: Original article
Authors: Maleev V.V., Mikhailova E.V., Chudakova Т.К., Romanovskaya A.M., Danilov A.N., Khripunova G.I., Dubovitskaya N.A.
Organization: Central Scientific Research Institute of Epidemiology, Saratov State Medical University
Summary:

Objective: To analyze the clinical and epidemiological characteristics in the post-pandemic influenza seasons in 2010/11/12/13 years. Material and methods: The analysis of the incidence of acute respiratory viral infections and flu in the Saratov region from 2009 to 2013. A clinical and laboratory examination of 252 patients with a diagnosis of «flu»: 152 pregnant women at different stages of pregnancy at the age of 18 years to 41 years and 100 children aged from 5 months to 14 years. The work was carried out to assess the epidemiological pattern and clinical course of influenza, and the effective operation of antiviral therapy. Results: In the post-pandemic period 2010-2013 simultaneously circulating influenza A viruses (N1N1/09) pd, influenza A (H3N2) and influenza B. In most cases, influenza in adults and children is of moderate form. All serious forms of influenza have been caused by influenza A with the development of viral-bacterial pneumonia, respiratory failure and neurotoxic syndrome. Late hospitalization and absence of antiviral therapy in the prehospital are at risk of severe and complicated forms. Conclusion: Early initiation of antiviral therapy is one of the main factors for the effectiveness of treatment and reduce the risk of influenza complications.

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Adaptive capacity of individuals suffered from diphtheria

Year: 2013, volume 9 Issue: №2 Pages: 178-186
Heading: Infectious Diseases Article type: Original article
Authors: Maleev V.V., Malyugina T.N., Zaytseva I.A., Tseka Yu.S.
Organization: Saratov State Medical University, Central Research Institute of Epidemiology
Summary:

The purpose is to reveal functional violations of various organs and systems at persons who have suffered from diphtheria and to develop algorithm of medical examination. Material and methods: 10 years» observation of over 722 patients who have had diphtheria has been made. Nuclear heating plants, ALT, glucose, urea, creatinine, troponin, blood myoglobin, creatinine of urine, SKF, LPI, anti-toxic antibodies, organ authoantibodies, interferons, AKTG, a corti-sol, TTG, ТЗ, T4, insulin and S-peptide, authoantibodies to thyroglobulin have been determined, an electrocardiogram, Doppler — and an echocardiography have been carried out. Results: It is revealed that at 59% of the persons who have had diphtheria, in the first three years catamnesis included the pathology of cardiovascular, nervous and urinary systems caused by existence of complications and a form of diphtheria in the acute period was created. It was accompanied by violation of functions of immune and hormonal systems: there was no protective anti-toxic immunity, autoimmune process was started, activity of the central and vegetative endocrine glands decreased. Depending on extent of these violations various options of disturbance of adaptation have been developed. At 5% of patients disturbance of adaptation resulted in lethal outcome. Conclusion: Functional violations of various organs and systems in catamnesis in persons who have had diphtheria have been revealed. The algorithm of medical examination for the purpose of regulation and correction of process of their adaptation has been offered.

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Disseminated leukoencephalitis and multiple sclerosis: cause and effect

Year: 2013, volume 9 Issue: №2 Pages: 170-178
Heading: Infectious Diseases Article type: Original article
Authors: Lobzin Y.V., Skripchenko N.V., Ivanova G.P., Komantsev V.N.
Organization: Federal State Budgetary Institution Scientific and Research Institute of Children»s Infections of Federal Medical and Biological Agency of Russia
Summary:

Aim: to define clinical and etiological, radiation and neurophysiological parameters determining the transformation of disseminated leukoencephalitis to multiple sclerosis in children. Materials and methods: clinical and etiological analysis of leukoencephalitis in 229 children aged 1-17 years old and their catamnesis for 5,5±1,8 years were performed. Morphostructural characteristic was made by brain and spinal cord MRI and multimodal provoked potentials. Results: The development of multiple sclerosis in children was observed in the outcome of leukoencephalitis chronic course in 44,4% of the cases and in 73,3% of the cases of mixed herpes viral infection (Epstein-Barr virus and 6 type herpes virus). Morphostructural features in the cases of leukoencephalitis in children depending on the disease course characterized by the prevalence of edematous and inflammatory character of CNS changes in the cases of an acute course, by demyelinating changes in the cases of a prolonged course, and by degenerative and demyelinating ones in the cases of a chronic course were determined. Administration of etiopathogenetic therapy for leukoencephalitis allows to achieve either a complete recovery or with the deficiency up to 2,5 points by EDSS in 96,6% in the cases of acute and prolonged course, and clinical and radiation remission in 50,1% and recovery in 5,5% in the cases of chronic course.

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Improvement of complex therapy of patients with pathology of scrotal organs formed by chronic brucellosis infection

Year: 2013, volume 9 Issue: №2 Pages: 165-170
Heading: Infectious Diseases Article type: Original article
Authors: Glybochko Р. V., Evdokimov A.M., Liapina Е.Р., Shuldiakov A. A., Ponukalin A.N., Blyumberg В.I., Sedova L.N.
Organization: First Moscow State Medical University n.a. I.M. Sechenov, Saratov State Medical University
Summary:

The aim of the study is to improve the treatment of patients with male reproductive organs pathology, formed by chronic brucellosis infection. Material and methods: We have analyzed the dynamics of the clinical manifestations of diseases of the scrotal organs, data of physical and ultrasound studies, semen parameters, the quality of life in 22 patients with chronic brucellosis and the presence of orchitis / orchiepididymitis against conventional therapy (10 patients), and combined treatment with the inclusion of cycloferon (i/m, 2 injection rate from 5 (0.25g) with a break 10 days) — 12. Results: We have proved ability of cycloferon to reduce the severity of the inflammatory process in the testis and epididymis, with improving of spermatogenesis and the quality of life for patients. We have marked the reduction in the number of exacerbations of chronic orchitis / orchiepididymitis 2.4 times after the course of cycloferon, its good tolerability of patients, no side effects. Conclusion: Using these results, the presence of anti-inflammatory and immunomodulatory potencies, cycloferon can be recommended in treatment of inflammatory lesions of the scrotal organs in patients with chronic brucellosis.

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Professor N.R. Ivanov and his contribution to the development of infectious service

Year: 2013, volume 9 Issue: №2 Pages: 163-165
Heading: Infectious Diseases Article type: Short message
Authors: Popkov V.M., Mikhailova Е.V., Zaitseva I.A.
Organization: Saratov State Medical University
Summary:

The article presents biographic data of professor N. R. Ivanov and reflectshis contribution to the development of the national department of infectious service and the department of children infectious diseases at Saratov Medical University.

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Clinical and immunological characteristics of hemorrhagic fever with renal syndrome in women of different age groups

Year: 2012, volume 8 Issue: №3 Pages: 765-769
Heading: Infectious Diseases Article type: Original article
Authors: Kutdusova A.M.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

Objective: To evaluate the clinical and immunological features of the hemorrhagic fever with renal syndrome in women of different age groups. Materials and methods: Clinical and laboratory characteristics of hemorrhagic fever with renal syndrome in 148 women aged 17 to 65 years old have been investigated. Patients have been divided into two groups: group I included 101 patients with normal menstrual rhythm, group II included 47 female patients with menopause. In 57 women (36 from group I, 21 — from group II) the content of CD3+, CD4+, CD8+, CD16+, CD19+ — sub-populations of peripheral blood lymphocytes has been determined. Results: In compared groups significant differences in structure and frequency of complications of the disease have been revealed. Unidirectional tendency to increase significantly reduced absolute rates of investigated lymphocyte subpopulations in dynamics of the disease has been identified. It also has been stated that by the time of early convalescence in case of severe form of HFRS the indices did not reach the standard level. In an older group of women deeper damage and long-term recovery of immune system have been marked. Conclusion: According to the results of clinical and immunological studies the research work has revealed that in young women the response of the immune system to HFRS has developed faster and stronger than that in patients during the menopause period.

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Dynamics of hormonal status in women of different age groups in hemorrhagic fever with renal syndrome

Year: 2012, volume 8 Issue: №2 Pages: 271-277
Heading: Infectious Diseases Article type: Original article
Authors: Kutdusova A.M., Murzabaeva R.Т.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

Objective: To study the hormonal parameters in women of different age groups in hemorrhagic fever with renal syndrome. Materials and methods: We have studied the content of cortisol, thyrotropic hormone (TTH), triiodothyro-nine (T3), free thyroxin (FT4), luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, estradiol, progesterone, prolactin in blood serum of 62 women with moderate (33) and severe (29) HFRS forms age (17-62). They were divided into 2 groups: the first group (33 patients) women with the normal menstrual cycle, the second group (29 women) consisted of patients in climacteric period. Results: TTH secretion increase, T3 and FT4 — decrease with their normalization to the recovery period were registered in the thyroid system of the compared groups. Blood cortisol level was high during the illness. Gonadotropic hypophysis function study demonstrated that LH and blood prolactin concentrations were increased since oliguria period; FSH was authentic reduced. The indices of these hormones were restored to the normal level by the reconvalescence period. LH and FSH contents were authentic higher in women of the second group in comparison with the first group. The hyperprolactinemia was observed in both women groups during the whole period of disease. The increased progesterone and testosterone concentrations have been manifested in blood serum. The estradiol concentration had different direction tendencies. Conclusion: Thus, the complex study of hypophysic- thyreoid and gonadotropic hormone state of adrenal system and the sexual hormone levels in women of different age groups in HFRS revealed the hormone status indces changes due to the period and severity of the disease, connected with the virus action, intoxication, the general inflammation reactions and their age.

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Level of circulating cytokines and microelements in patients with hemorrhagic fever accompanied by renal syndrome

Year: 2011, volume 7 Issue: №4 Pages: 863-865
Heading: Infectious Diseases Article type: Short message
Authors: Khasanova G.M.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

The research goal is to examine the interrelation of cytokines level (INF-y, TNF-a, IL-2, IL-4, IL-10) and concentration of microelements in blood of patients with hemorrhagic fever accompanied by renal syndrome. 292 patients aged 18-59 years have been examined.Enzyme immunodetection has been carried out by using reagents from «Vector-Best» (Novosibirsk). The content of microelements in blood plasma has been estimated by mass spectrometry with inductively coupled plasma (ICP-MS; Elan-9000, PerkinElmer, USA) and atomic emission spectrometry with inductively coupled plasma (ICP-OES; Optima-2000 DV, PerkinElmer, USA). A direct correlation between zinc, selenium, the level of IL-2 and lead, aluminum, the level of TNF-a has been found out. The negative correlation between aluminum concentration and the level of IF-y has been determined

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