Saratov JOURNAL of Medical and Scientific Research

autoantibodies

Immunological Indices At Gerontological Patients With Ischemic Heart Disease, Metabolic Disturbances And Osteoporosis

Summary:

Gerontological patients with ischemic heart disease which is not accompanied by such pathology as diabetes (SD) and osteoporosis (OP) with normal or increased body weight (females) generally have got «the highest potential of health». It has been proved by phase portraits and autoantibodies (AAb) and cytokines indices. Adaptative disturbances in these groups have been revealed at the age of 95 and 89 accordingly. The presence of such accompanying pathology as SD and OP causes dysadaptation. It is evident by means of autoantibodies (AAb) and cytokines indices and phase portraits of «temporary dependence of general cholesterol levels - its first derivative»

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Liver Functional State Changes At Epstein-Barr Virus Mononucleou-sis In Children

Year: 2009, volume 5 Issue: №4 Pages: 572-577
Heading: Infectious Diseases Article type: Original article
Authors: S.A. Khmilevskaya, LA. Zaytseva, E. V. Mikhailova
Organization: Saratov State Medical University
Summary:

The research presents the results of medical observation of 439 patients aged 1-18 with mononucleosis of Epstein-Barr Virus etiology. By means of instrumental and clinical laboratory methods of investigation the peculiarities of liver condition have been revealed in children of different age. The intensity of autosensibilization processes to the tissues of the organ has also been estimated. The results obtained demonstrate the interrelation of clinical, biochemical and instrumental signs of liver damage, as well as contribution of autoimmune processes to the development of organopa-thology at Epstein-Barr Virus infection

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IMMUNOLOGIC INDICES IN GERONTOLOGICAL PATIENTS WITH ISCHEMIC HEART DESEASE AND URINARY SYSTEM PATHOLOGY

Summary:

Patients of middle and old age with ischemic heart desease and diseases of urinary system (DUS) have been examined. Leukocytic index of intoxication (Lll), hematologic parameter of intoxication (HPI), parameter of immunity intensity (Pll) have been significantly increased in groups of patients with benign prostatic hyperplasia, diabetes and DUS. These indices have been directly correlated with content of IL6 and TNFa, and examined autoantibodies (AAb), especially with contents of antibodies to DNA, to collagen, to fiber-regulator of differentiation and migration immature neuroblast S100. Indices of Lll, HPI and Pll have been decreased in group of patients with normal body weight and urolithiasis. In this group the increase of allergization index (Al) and content of IL6, TNFa has been noticed. Indices of AAb pointed to metabolic disorders. The increase of cytokines in patients with pyelonephritis has been revealed. Content of AAb has been slightly increased in comparison with normal indices

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Epstein-Barr Viral Infection in Children: Cytokine Response Peculiarities and Immunopathological Reactions

Year: 2009, volume 5 Issue: №2 Pages: 222-226
Heading: Infectious Diseases Article type: Original article
Authors: S.A. Khmilevskaya, I.A. Zaytseva, E.V. Mikhaylova
Organization: Saratov State Medical University
Summary:

The research results are presented in the work. 100 patients aged 1–18 with different Epstein-Barr viral infection course variations have been observed. Clinical features of infectious mononucleosis in case of primary infection and its revivification have been revealed. The evaluation of intensity of autosensibilization processes has been performed. The interrelation of autoimmune and cytokine reactions and their participation in formation of organopathology in case of Epstein-Barr viral infection are demonstrated.

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