Saratov JOURNAL of Medical and Scientific Research

rheumatoid artritis

A clinical case of fast progression of amyloidosis of kidneys in rheumatoid arthritis

Year: 2017, volume 13 Issue: №4 Pages: 821-823
Heading: Internal Diseases Article type: Case report
Authors: Romanova I.A., Magdeeva N.A., Nikitina N.M.
Organization: Saratov State Medical University
Summary:

The article presents clinical case of unfavorable outcome of amyloidosis of kidneys in a patient with rheumatoid arthritis. The absence of basic treatment and persistent activity of disease leads to fast progression of nephrotic stage of secondary amyloidosis in a young woman.

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Pharmacoeconomic analysis of treatment of rheumatoid arthritis of the early stage and the most frequent comorbide conditions

Year: 2017, volume 13 Issue: №3 Pages: 462-468
Heading: Parmacology Article type: Original article
Authors: Okonenko T.l., Khrutsky А.К., Okonenko L.B., Egorova E.S.
Organization: Yaroslav-the-Wise Novgorod State University
Summary:

Objective: to define the regional structure of comorbid conditions of early rheumatoid arthritis (RA) and the cost of treatment. Material and Methods. Medical records of 100 patients with RA hospitalized in Velikiy Novgorod in 2010 and 2014 were analyzed. Range of drugs, used by doctors in the early stage of RA were considered, and and drugs were systematized. Pharmaceutical and economic analysis of medical records was conducted. Statistical data processing was executed using MS Excel. Results. A wide distribution of comorbid conditions in patients with early state of rheumatoid arthritis was established, the structure of concomitant pathology was determined. All the prescribed drugs and preparations with a frequency of more than 3% are allocated. The average cost for each drug use has been calculated, an ABC-analysis has been performed. Conclusion. Comparison of medical appointments and regulatory lists revealed that the standard is not fully observed. At an early stage of RA a high percentage of patients with comorbid conditions was noted (85.7-93.3%), predominantly cardiovascular, gastrointestinal, thyroid diseases. Cost of treatment of RA at an early stage and the most frequent comorbid status in 2014 has increased in comparison with 2010, the range of drugs in 2014 has decreased by 32%. The results of ABC-analysis of medicinal appointments revealed qualitative and quantitative changes in the major positions of the drugs.

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The influence of CCPA and RF on the five-year outcomes in patients with early rheumatoid arthritisиве

Year: 2015, volume 11 Issue: №2 Pages: 135-141
Heading: Internal Diseases Article type: Original article
Authors: Ermakova Yu.A., Karateev D.E., Luchikhina E.L., Demidova N.V.
Organization: Moscow V.A. Nasonova Research Institute of Rheumatology
Summary:

Objective: to study the influence of CCPA and RF on 5-year outcomes in patients with early rheumatoid arthritis (RA). Subjects and methods. 204 patients with early RA (0,05. From 2 to 5 years — 33,5±20,8 (25,3±14,2), 40,8±26,8 (31,9±20,2), 48,0±28,8 (37,2±22,6), 55,6±30,5 (44,0±24,5), respectively, p

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Non-pharmacological treatment effects on psychosomatic and immune regulatory mechanisms in patients with rheumatic arthritis

Summary:

Objective: comparative analysis of the influence of the methods of the lateral ophthalmotilapia and low-intensity magnetic therapy on the Central and peripheral nervous system and the immune status in patients with rheumatoid arthritis. Material and methods: a comparative analysis of the impact of the 44 patients with rheumatoid arthritis aged 18 to 65 years, of which 19 patients (43.2 percent) — 1 group received low-frequency low-intensity magnetic therapy and 25 patients (56.8 per cent) — group 2, the lateral ophthalmotilapia. Results. In group 1 significantly improved memory both short-term (from 69.2±9.0 to 81,7±12,7, p=0.003), and the reminiscence relating to medium-term characteristics of memory (57,3±22 to 79,0±14,5; p=0.004). In patients of the 2nd group in the course of treatment was observed more pronounced dynamics of improvement of parameters of higher nervous activity, namely short-term memory (79,4±17 to 88,2±12, p=0.003)and reminiscences of memory (from 69.4±27 to 82.4±19,5, p=0,0016). Conclusion. Lateral ophthalmotilapia and low-frequency magnetotherapy for help expand the list of rehabilitation programs in rheumatoid arthritis, the disease having dual autoimmune and psychosomatic genesis.

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Modern methods of early diagnostics of juvenile arthritis

Year: 2013, volume 9 Issue: №2 Pages: 308-313
Heading: Pediatrics Article type: Review
Authors: Chernenkov Y.V., Zakharova N.B., Kuzmina А.А., Spivakovsky Y.M.
Organization: Saratov State Medical University
Summary:

The problem of inflammatory diseases of joints is one of the most important issues in the pediatrics. Nowadays the significant attention in this sphere is paid to the search of new accurate criteria of diagnostics. It will help estimate the severity of disease, determine the prognosis, choose the method of treatment and monitoring and evaluate the efficacy of the therapy.

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DYNAMICS OF CYTOKINE ACTIVITY IN PATIENTS’ BLOOD SERUM

Year: 2008, volume 4 Issue: №4 Pages: 56-58
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Z.S. Topchieva, G.P. Gladilin, N.I. Zryachkin
Organization: Tambov City Hospital №4, Saratov State Medical University
Summary:

In this work dynamics ofinflammatoryandanti-inflammatory cytokines in blood serum of 65 patients with atrophic arthritis depending on activity, duration of inflammatory process, presence or absence of the rheumatoid factor is represented.
It is determined: that the level ofФНО-а in blood serum among patients with atrophic arthritis does not depend upon the growth of an inflammatory process’s activity and presence or absence of the rheumatoid factor, but it depends upon the clinical course’s duration. The maintenance of ИФ-у and ИЛ-4 in patients' blood serum with atrophic arthritis depends upon a degree of an inflammatory process’s activity and does not depend upon the clinical course’s duration and presence or absence of the rheumatoid factor.

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LIPID DISORDERS IN PATIENTS WITH RHEUMATOID ARTHRITIS

Year: 2007, volume 3 Issue: №1 Pages: 24-27
Heading: Internal Diseases Article type: Review
Authors: Nikitina N.M., Lobanova O.S., Rebrov A.P.
Organization: Saratov State Medical University
Summary:

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder that occurs in approximately 0,5- 1% of the population. Patients with RA experience a shorter life expectancy than the general population. A large proportion of the excess mortality in persons with RA is related to cardiovascular disease. Ccardiovascular disease in RA may result from, accelerated atherosclerosis. The main risk factors for cardiovascular disease in the general population are the disorder of lipic profile. This article gives a review of the present data of the change in lipid profiles in RA at effects of anti-rheumatic treatment in the lipid profile in RA.

Some Peculiarities of Bone Tissue Remodelling at Hip Joint Inflammatory and Degenerative Diseases

Year: 2009, volume 5 Issue: №2 Pages: 227-230
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: E.V. Karyakina, E.A. Persova
Organization: Saratov Scientific Research Institute of Traumatology and Orthopedics
Summary:

During the assessment of peculiarities of bone tissue remodelling in inflammatory and non inflammatory lesions of hip joint, according to the levels of biochemical indices in the blood serum, some unilateral changes of bone tissue metabolism have been revealed in advanced rheumatoid arthritis and osteoarthrosis. More severe disturbances of bone remodelling in case of rheumatoid arthritis are obviously connected with peculiarities of the rheumatoid inflammation pathogenesis.

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Data Of Daily Blood Pressure Monitoring In Patients With Rheumatoid Arthritis

Year: 2009, volume 5 Issue: №2 Pages: 190-164
Heading: Internal Diseases Article type: Original article
Authors: N.M. Nikitina, O.S. Lobanova, A.P. Rebrov
Organization: Saratov State Medical University
Summary:

The aim of present work is to study the frequency of hypertension and the peculiarity of 24-hour blood pressure monitoring in patients with rheumatoid arthritis. We studied 584 patients with rheumatoid arthritis. Daily blood pressure monitoring was carried out in 46 patients with arthritis and 18 patients with essential hypertension. Frequency of hypertension was higher in patients with arthritis then in general population. Elevation of systolic blood pressure, heart rate and arterial blood pressure adequate decrease at night were developed to associate with advance of the disease.

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