Saratov JOURNAL of Medical and Scientific Research

immunomodulator

Christ — Siemens — Touraine syndrome (ectodermal anhydrone dysplasia)

Year: 2011, volume 7 Issue: №3 Pages: 670-672
Heading: Pediatrics Article type: Short message
Authors: Kuznetsova М.А., Karalskaya J.J.
Organization: Saratov State Medical University
Summary:

The article is concerned with observation of a child of 3,5 with hereditary Krista — Seimens — Turena syndrome. The clinical description of the syndrome and modern approaches to treatment have been analyzed

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Clinico-Immunological Estimation of Application of Immunomodulatory Medicine «Gepon» in Complex Therapy of Inflammatory Periodontium Diseases

Year: 2009, volume 5 Issue: №2 Pages: 238-242
Heading: Stomatology Article type: Original article
Authors: N.V. Bulkina, A.P. Glybochko
Organization: Saratov State Medical University
Summary:

Results of immunumodulator «Gepon» application in complex therapy of chronical generalized periodontitis are given. The efficacy of medicine was improved in renewal of cytokine profile balance in contents of periodontal pockets. It is shown that local application of “Gepon” allows to rise the quality of treatment; to decrease the preoperative preparation term to 10 days (for traditional treatment 14–16 days); to accelerate the postoperative rehabilitation of patients; try to obtain stabile remission in 82% of cases with light degree of chronic periodontitis and 77% with medial degree of periodontitis after 6 month of supervision.

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New Routs In Optimization Therapy of Helicobacter Pylori Eradication in Patients with Chronic Duodenal Ulcer

Year: 2009, volume 5 Issue: №2 Pages: 200-203
Heading: Internal Diseases Article type: Original article
Authors: V.V. Dugina, N.S. Khruleva
Organization: N. Novgorod State Medical Academy
Summary:

Pharmacological effects of immunomodulators produce normalization of immunochemical function of homeostasis. This phenomenon determines optimization of Helicobacter pylori eradication. The combination of immunomodulators with antibiotics has a double effect. Antibiotics destress the functional activity of microorganisms and increase it’s sensitivity to the effect of phagocytes. On the other hand immunomodulators increase functional activity of phagocytes to eliminate microorganizms Оptimization of Helicobacter pylori eradication by using of immunomodulators is necessary for clinical practice. It includes prophylaxis of recurrences and complications caused by drugs action on immune system in patients with chronic diseases.

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Interferon Tiloron Inductor Usage in Complex Therapy at Patients with Community-Acquired Pneumonia

Year: 2009, volume 5 Issue: №2 Pages: 187-190
Heading: Internal Diseases Article type: Original article
Authors: O.A. Kiseleva, G.N. Shemetova, N.B. Zakharova
Organization: Saratov State Medical University
Summary:

The article presents the research findings concerning the importance of changes of the contents in blood serum of interferon gamma (INF-?), interferon alfa (INF-?), the tumor necrosis factor alfa (TNF-?), interleukin 4 (IL-4), interleukin8 (IL-8) and clinical parameters at patients with community-acquired pneumonia before the end of treatment (basic therapy and with immunomodulator tiloron). Tiloron positive influence on clinical manifestations and immunological parameters (profile of cytokines– IL-4, IL-8, INF-?, INF-? and INF-?) has been detected in patients with slightly complicated community-acquired pneumonia in 95 % of cases.

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