Saratov JOURNAL of Medical and Scientific Research

Gileva E.V.

Saratov State Medical University n.a. V.I. Razumovsky, the Clinic of Eye Diseases, Chief of the Diagnostic Ophthalmology Department, Candidate of Medical Science

Experience of antiangiogenic and corticosteroid therapy of a diabetic macular edema

Year: 2017, volume 13 Issue: №2 Pages: 383-388
Heading: Ophtalmology Article type: Original article
Authors: Kamenskikh T.G., Batishcheva Yu.S., Kolbenev I.O., Tsipyashchyk A.F., Andreychenko O.A., Gileva E.M., Vasil'yeva T.V., Zakharova N.B.
Organization: Saratov State Medical University
Summary:

Diabetic macular edema (DME) is a leading cause of blindness in patients with diabetes. The purpose of the research is to evaluate the effectiveness of treatment of patients with DMOs resistant to the administration of ranibi-zumab, using the intrauritreal implant "Ozurdex". Material and Methods. 66 patients (98 eyes) are examined. All of the patients were divided, into three groups, depending on a stage of a diabetic retinopathy. The patients underwent a complex of examinations: along with traditional methods, optical coherence tomography, fluorescence angiography of the fundus, multifocal electroretinography, determination of the content of VEGF-Aand cytokines in serum were used. Results. According to ОСТ of a retina and a visometry there are differences in efficiency of treatment depending on a condition balance of cytokine. Conclusion. The use of the intrauretic implant "Ozurdex" was more effective in patients with DMO in the stage of p re-pro I iterative diabetic retinopathy and in patients resistant to anti-VEGF therapy.

AttachmentSize
2017_02-1_383-388.pdf2.1 MB

Fluorescent angiography and optical coherence tomography with angiography of the ocular fundus in patients with "the wet" form of an age-related macular degeneration.

Year: 2017, volume 13 Issue: №2 Pages: 345-349
Heading: Ophtalmology Article type: Original article
Authors: Virsta A.M., Kamenskikh T.G., Nugaeva N.R., Kolbenev I.O., Gileva E/V.
Organization: Saratov State Medical University
Summary:

Purpose: to investigate the informative value of fluorescent angiography (FA) and optical coherence tomography with fundus angiography (angio-OCT) in the diagnosis of "wet" form of age-related macular degeneration (AMD). Material and methods. The present study included 20 patients (20 eyes) diagnosed with degeneration of macula and posterior pole of the eye, the "wet" form (late stage age-related macular degeneration, AREDS category 4). The study used machines: optical coherence tomography, Spectralis HRA+OCT (Heidelberg Engeneering, Germany), optical со- herence tomography-angiography CIRRUS HD-OCT MODEL 5000 (Carl Zeiss, Germany). Results. When conducting the FA, in 11 patients found the ill-defined zone of small leakage of dye in 7 patients revealed a clearly defined area of hyperfluorescence in the early phase, and marked leakage of dye in the late phase, 2 patients — uncertain indices. In connection with the received data questionable PHAGE in 11 patients, all were held angio-OCT, to clarify the localization of choroidal neovascularization (CNV). When performing angio-OCT in 11 patients revealed that "wet" form of AMD with occult choroidal neovascularization. In 7 patients there had been discovered classic CNV in 2 patients combined. Conclusion. Angio-OCT gives a clearer picture about the presence of a choroidal neovascular membrane that plays a significant role in determining the course of treatment of patients with wet age-related macular degeneration.

AttachmentSize
2017_02-1_345-349.pdf1.97 MB

The efficiency of modern methodics of laser refractive surgery according to the clinical experience of the Ophthalmology Clinic of the Saratov State Medical University.

Year: 2017, volume 13 Issue: №2 Pages: 334-338
Heading: Ophtalmology Article type: Original article
Authors: Barabanova L.S., Kamenskikh T.G., Belousova T.V., Gileva E.M.
Organization: Saratov State Medical University
Summary:

The purpose of study is to compare an effectiveness of different refractive laser surgery methods. Material and methods. 72 LASIK patients (141 eyes) and 21 TransPRK patients (39 eyes) were analyzed. Among them there were 42 women and 50 men. The age of patients at the operation moment was from 18 to 46 years. Patients were divided into 3 groups, according to myopia rate. The research method is descriptive statistics. Results. A differentiated approach to the choice of surgery gives the maximum possible and stable functional result. Confocal corneal microscopy data show a decrease in the corneal epithelium of the number of cells with large nuclei (markers of hypoxia) in operated patients, in contrast to patients using contact lenses. This confirms the advantage of laser correction in comparison with contact correction of myopia. Conclusion. High and stable recuperated vision sharpness at all patients attests eximer-laser correction efficiency and safety under any myopia rates.

AttachmentSize
2017_02-1_334-338.pdf585.95 KB