Saratov JOURNAL of Medical and Scientific Research

insulin resistance

Adipokines and their possible role in obesity and type 2 diabetes mellitus

Year: 2018, volume 14 Issue: №2 Pages: 201-206
Heading: Endocrinology Article type: Review
Authors: Kuznetsova L.A., Shpakov А.О.
Organization: I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Laboratory of Molecular Endocrinology and Neurochemistry
Summary:

The adipose tissue is the endocrine organ secreting polypeptide factors, such as adipokines, which are involved in the regulation of feeding behavior, the metabolic, endocrine and inflammatory processes and insulin sensitivity. In obesity and type 2 diabetes mellitus (DM2), the production of adipokines and the activity of their signaling pathways are changed, which plays an important role in the relationship between obesity, insulin resistance and DM2. In the review (according the types of obesity) the data on the production of adipokines with diabetogenic (leptin, visfatin, chemerin, vaspin, apelin, resistin) and antidiabetic (adiponectin, omentin) properties by the adipose tissue, as well as the possible role of adipokines in the development of obesity and DM2 were discussed.

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Molecular and genetic predisposing factors of comorbidity of fatty liver disease and diseases of the colon

Year: 2017, volume 13 Issue: №1 Pages: 029-034
Heading: Internal Diseases Article type: Review
Authors: Lapteva Е.А., Kozlova I.V.
Organization: Saratov State Medical University
Summary:

The literature review is devoted to the universal molecular markers and predictors of forming non-alcoholic fatty liver disease and pathology of the colon, the role of insulin resistance as one of the factors of the pathogenesis of non-alcoholic fatty liver disease in the development of colorectal cancer. The mechanisms of diseases of the colon (colorectal cancer) are found out to be due to non-alcoholic fatty liver disease.

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