Saratov JOURNAL of Medical and Scientific Research

hepatocellular carcinoma

Transarterial chemoembolization for primary and metastatic liver tumors

Year: 2016, volume 12 Issue: №4 Pages: 716-720
Heading: Oncology Article type: Review
Authors: Popov M.V., Aronov M.S., Voskanyan S.E., Karpova O.V.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

The literature review presents the methodology of transarterial chemoembolization (TACE) — widely used method of treatment of primary and secondary liver tumors. The TACE role as a neoadjuvant therapy and the role in the management of unresectable primary and secondary liver tumors are shown. The morphofunctional basis of TACE, benefits of superselective intra-arterial administration of cytostatic agents especially in combination with ischemic impact on a tumor are described. The subject of the choice of the chemotherapeutic agent is also touched; modern drug-loaded microspheres which allow the use of higher doses of the chemotherapeutic drug without increasing systemic effect and prolong its effect on tumor are described. Lack of correlation of presence and severity of a post-embolization syndrome with success of the procedure is noted.

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