Saratov JOURNAL of Medical and Scientific Research

Stavropol State Medical University

Effectiveness of neure-protective therapy in patients with glaucoma

Year: 2018, volume 14 Issue: №4 Pages: 828-831
Heading: Ophtalmology Article type: Case report
Authors: Aprelev А.Е., Barbos Yu.A., Mukhanko I.Zh., Cherednichenko N.L., Abdulgazizova Z.F., Kataganova A.A., Bernovskaya A.A.
Organization: Mineralovodsky district hospital, Orenburg Regional Clinical Hospital, Orenburg State Medical University, Regional Clinical Diagnostic Center in Stavropol City, Stavropol Regional Clinical Hospital, Stavropol State Medical University
Summary:

The results of clinical evaluation of three patients who were included in the multicenter study of the
effectiveness of neuroprotective treatment and its impact on the quality of life of patients with POAG are
presented in the article. Dynamics of visual acuity, intraocular pressure, total visual fields, photostress
test, contrast sensitivity and quality of life (according to the NEIVFQ-25 questionnaire) in patients
treated with neuroprotective study drug with 10 intramuscular injections administered 5mg once a day
are presented. Data on the improvement of visual functions and quality of life in patients with Stage I, II
and III of POAG who had undergone treatment with the study drug are demonstrated.

Keywords: quality of life
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The influence of different variants of glucose-lowering therapy on indices of inflammation in patients with diabetes type 2 on a background of gastroesophageal reflux disease and obesity

Year: 2018, volume 14 Issue: №3 Pages: 368-372
Heading: Internal Diseases Article type: Original article
Authors: Andreeva E.l.
Organization: Stavropol State Medical University
Summary:

Aim: to evaluate the effect of different types of hypoglycemic therapy on the level of leptin, interleukin-6, C-reactive protein, tumor necrosis factor-alpha, as well as body mass index. Material and Methods. The study involved 250 people. 200 case histories of patients with the main diagnosis Gastroesophageal Reflux Disease were analyzed. Group I consisted of 50 suffering from diabetes type II diabetes in combination with obesity of varying severity and GERD. Treatment of diabetes in this group was carried out with the help of Metformin. Group II consisted of 50 patients with type II diabetes mellitus combined with obesity of varying severity and gastroesophageal reflux disease. Patients in this group took exenatide. Group III consisted of 50 patients suffering from obesity of different severity and gastroesophageal reflux disease. The comparison group (IV) consisted of 50 patients with gastroesophageal reflux disease without overweight and comorbidities. For the treatment of GERD in the study subjects used — omeprazole. The control group (V) consisted of 50 healthy volunteers. Laboratory tests (General blood test, biochemical, immunological parameters) were performed on automated hematological (Ruby), immunochemical (Architect 2000) and biochemical (Architect 4000) analyzers (Abbott, USA). Results. In the course of assessing the indicators before therapy, we can note an increase in the level of leptin in the group of patients with obesity, while against the background of type 2 diabetes. Assessing the level of interleukin-6, C-reactive protein, tumor necrosis factor-alpha statistically significant increase in indicators was observed in the groups of patients with obesity (I, II, III study group). As a result of treatment, weight loss in patients of group II correlated with a decrease in the level of leptin, interleukin 6, C-reactive protein and TNF. Conclusion. As a result of treatment with exenatide, weight loss in patients of group II correlated with a decrease in the level of leptin, interleukin 6, C-reactive protein and TNF, indicating a decrease in the metabolic activity of visceral fat, which consists in the activation of lipolysis, release of free fatty acids and adipocytokines

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Features of the clinical course of gastroesophageal reflux disease associated with obesity

Year: 2018, volume 14 Issue: №1 Pages: 42-45
Heading: Internal Diseases Article type: Original article
Authors: Andreeva E.l.
Organization: Stavropol State Medical University
Summary:

The research goal is to reveal the features of clinical manifestations of gastroesophageal reflux disease (GERD) in obesity. Material and Methods. A survey and anthropometric study of 51 patients suffering from GERD and obesity aged 30 to 60 years were conducted. The average age of the patients was 42.3±2.11 years. Patients were divided into groups according to the BMI score. The control group consisted of patients suffering from GERD without obesity. Results. The main complaint of the patients of the control group was heartburn, while the patients of the main group had complaints of dyspeptic nature. With an increase in BMI, there was an increase in the incidence of complaints, in addition, complaints of an extra-esophageal nature associated with the direct effect of acidic gastric contents on the pharyngeal mucosa were detected. This regularity is explained in the article by pathogenetic mechanisms of GERD development. In patients suffering from GERD without obesity, the development of the disease is caused by a change in the motor activity of the esophagus due to a decrease in the tone of the lower esophageal sphincter, and in patients with co-pathology the main role is given to increased intragastric pressure, which leads to disruption of the sphincter. Conclusion. Thus, the clinical picture of combination of GERD and obesity differs atypical for GERD current, the main features of which are the predominance of dyspeptic complaints, motor-evacuation disorders, and the presence of extraesophageal complaints.

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Peculiarities of clinical course of gastroesophageal reflux disease in patients with type 2 diabetes and obesity

Year: 2017, volume 13 Issue: №4 Pages: 809-812
Heading: Internal Diseases Article type: Original article
Authors: Andreeva E.l.
Organization: Stavropol State Medical University
Summary:

Aim: to study the clinical course of gastroesophageal reflux disease (GERD) in patients with type 2 diabetes and evaluation of the parameters of the esophagus 24-hour pH-metry. Material and Methods. In the examination of patients with GERD, three groups of patients were selected for 50 people each. The first group includes patients with GERD with combined course of obesity and type 2 diabetes (mean age 54.6±2.73 year; 32 females and 18 males). The second group included patients with GERD against obesity (mean age 42.3±2.11 year; 30 females and 20 males). The control group consisted of patients with GERD without excess body weight and concomitant pathology (average age43.6±2.11 year; 29 females and 21 males). In addition to collecting complaints and anamnesis, the patients and the control group underwent a 24-hour pH-metric study of the esophagus according to a conventional method. Results. Patients suffering from GERD in the background of type 2 diabetes have a clinically asymptomatic or asymptomatic course; there is a significant increase in the daily pH-metry, indicating a more pronounced nature of the changes. Conclusion. Patients suffering from GERD in the background of type 2 diabetes require a comprehensive examination of the upper digestive tract to identify GERD, even if there are no complaints characteristic of the disease.

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Effectiveness evaluation of application of niosomal gel "Regenerin" in the treatment of chemical burns of cornea

Year: 2017, volume 13 Issue: №2 Pages: 216-220
Heading: Microbiology Article type: Original article
Authors: Bazikov I.A., Botasheva V.S., Kalinkina N.I., Maltsev A.N., Kostyukova N.Yu., Domenyuk D. A.
Organization: Stavropol State Medical University
Summary:

The aim of the work was to study the effectiveness of using the ophthalmic gel "Regenerin" in the treatment of a simulated chemical burn of the cornea in an experiment. Material and Methods. The chemical composition of the drug "Regenerin" was studied by mass spectrometry The regenerative action of the niosomal gel, including low molecular weight peptides extracted from placental cells and encapsulated, was then studied in 40 organisms of 20 rabbits of the chinchilla breed with a 10% solution of caustic soda. The subjects of the study are divided equally into two groups: in the experimental group, the treatment was carried out by applying a gel to the burn surface, the therapy was not performed in the control group. Results. The result of treatment with the "Regenerin" Ophthalmic Gel is a significant reduction in the timing of reparative regeneration in the animals of the experimental group due to increased metabolism and corneal neovascularization processes. Conclusion. The combined effect of these mechanisms, manifested in the arrest of edema, resorption of inflammatory infiltrates, normalization of the integrity of the endothelium, epithelial layer and basal membrane leads to completely restoring the histological structure of the cornea on the seventh day.

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Effectiveness evaluation of application of niosomal gel "Regenerin" in the treatment of chemical burns of cornea

Year: 2017, volume 13 Issue: №2 Pages: 216-220
Heading: Microbiology Article type: Original article
Authors: Bazikov I.A., Botasheva V.S., Kalinkina N.I., Maltsev A.N., Kostyukova N.Yu., Domenyuk D. A.
Organization: Stavropol State Medical University
Summary:

The aim of the work was to study the effectiveness of using the ophthalmic gel "Regenerin" in the treatment of a simulated chemical burn of the cornea in an experiment. Material and Methods. The chemical composition of the drug "Regenerin" was studied by mass spectrometry The regenerative action of the niosomal gel, including low molecular weight peptides extracted from placental cells and encapsulated, was then studied in 40 organisms of 20 rabbits of the chinchilla breed with a 10% solution of caustic soda. The subjects of the study are divided equally into two groups: in the experimental group, the treatment was carried out by applying a gel to the burn surface, the therapy was not performed in the control group. Results. The result of treatment with the "Regenerin" Ophthalmic Gel is a significant reduction in the timing of reparative regeneration in the animals of the experimental group due to increased metabolism and corneal neovascularization processes. Conclusion. The combined effect of these mechanisms, manifested in the arrest of edema, resorption of inflammatory infiltrates, normalization of the integrity of the endothelium, epithelial layer and basal membrane leads to completely restoring the histological structure of the cornea on the seventh day.

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The effect of Mexidol on magnesium-calcium balance and endothelial dysfunction in operational stress

Year: 2014, volume 10 Issue: №1 Pages: 167-170
Heading: Рharmacology Article type:
Authors: Baturin V.A., Fisher V.V., Sergeev S.A., Yatsuk I.V.
Organization: Stavropol State Medical University
Summary:

The aim of the study: to study the effect of mexidol content of ionized calcium and magnesium in erythrocytes and the number of circulating endothelial cells in patients undergoing surgery in the maxillofacial area. Material and methods. The intracellular concentration of calcium and magnesium was measured before the operation, in one, three and five days after the surgery with the help of cytochemical method. Mexidol (100mg) was administered intravenously as a single addition to the standard premedication. Results. After surgery, the intracellular calcium and magnesium content increased. After 24 hours, the magnesium level began to decline, and the calcium content in erythrocytes continued to grow. On day 5, the magnesium concentration in erythrocytes decreased below the initial level, and calcium levels remained significantly elevated. Number of endothelial cells in the blood increased immediately after surgery and magnesium-calcium balance and limits endothelial dysfunction. Mexidol continued growing, reaching a peak on day 5 after surgery. When using mexidol decreased levels of calcium and magnesium levels help prevent falls on the 5th day after surgery, decreased the number of circulating endothelial cells. Conclusion. Mexidol prevents postoperative magnesium violation.

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Clinical way method in treatment of out-patients with ischemic heart disease after cardiosurgery

Year: 2010, volume 6 Issue: №4 Pages: 824-828
Heading: Sociology of Medicine Article type: Original article
Authors: Vardosanidze S.L., Galstyan A.S.
Organization: Stavropol State Medical University
Summary:

158 patients with ischemic heart disease (IHD) have been understudy during the period of 12 months in out-patient conditions. After completion of the primary examination all the patients of basic group (118 patients) received clinical way method of treatment. Patients of the comparison group (40 patients) after provided treatment were cared by their local therapeutists (cardiologists). The findings proved the fact that treatment of patients after cardiosurgery by clinical way method in out-patient conditions enabled to raise patient motivation to treatment, thereby assisting them to feel better, promoting normalization of arterial pressure data. The research results stated that clinical way method of treatment may be considered as rational and effective

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Clinicl-and-experimental application of osteoplastic substances in extraction of retenial and dystopic lower third molars

Year: 2010, volume 6 Issue: №1 Pages: 136-139
Heading: Stomatology Article type: Original article
Authors: S.V. Sirak, A.A. Korobkeev, K.I. Sapunov, A.D. Chitanova
Organization: Stavropol State Medical University
Summary:

The research objective was to develop surgical methods of retenial and dystopic third lower molars extraction by means of modern osteoplastic substances. the used materials included advanced osteoplastic techniques. Application of osteoplastic substances in extraction of retenial and dystopic third lower molars reduced postoperative complications by 41,9 percent compared with those in the control group. the work gives close attention to the obtained data. It points out the high level of intensity of osteoreparative process. in conclusion there is a recommendation of complex application of described substances in clinical practice

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Contemporary methods of investigation of heart bloodstream

Year: 2010, volume 6 Issue: №1 Pages: 026-028
Heading: Macro- and Micromorphology Article type: Original article
Authors: A.A. Korobkeev, O.Yu. Lezhnina, M.A. Basakov, O.N. Astakhova, I.I. Fedko, N.V. Neyzhmak
Organization: Stavropol State Medical University
Summary:

The objective of the research is to present morpho-functional parameters that characterize spatial arrangement of arterial and venous circulation of human heart. Research material includes heart vessels of people belonging to different age groups. In conclusion the scientific work points out that the obtained parameters give the possibility to evaluate and compare the spatial arrangement of arteries and veins in different topographic regions of heart

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