Saratov JOURNAL of Medical and Scientific Research

metabolic syndrome

Psoriasis, cardiovascular syndrome and methotrexate

Year: 2016, volume 12 Issue: №3 Pages: 490-492
Heading: Dermatovenerology Article type: Author's opinion
Authors: Utz S.R., Juke A.N.
Organization: Saratov State Medical University
Summary:

Often while treating psoriasis, clinicians face great difficulty in choosing the best treatment for patient and often face the question such as: what preparation is more suitable in a concrete case? Especially in psoriasis associated with comorbid diseases. In this article the data from Russian and foreign literature is collected about the effectiveness of methotrexate (in small and medium doses) in treating not only psoriasis but also other comorbid diseases. The positive effects of this medication from cytostatic group having not only anti-tumor activity but also immunosuppressive effect are evident not only on underlying disease, but also on the associated disease that has similar pathogenesis.

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Siofor influence on the process of lipid peroxidation and antioxidant status at patients with metabolic syndrome

Year: 2013, volume 9 Issue: №4 Pages: 744-748
Heading: Endocrinology Article type: Original article
Authors: Chernysheva E.N., Panova T.N.
Organization: Astrakhan State Medical Academy
Summary:

The Purpose of the work is to research siofor influence (metformin) on the activity of the process of lipid peroxidation and antioxidant activity of blood serum at patients with metabolic syndrome. Material and Methods. 62 patients with metabolic syndrome at the age from 30 till 60 were examined and treated by siofor (1700 mg per day) during a year. The process of lipid peroxidation was studied due to the level of lipid hydroperoxide of blood serum. Antioxidant capacity was based on the antioxidant reaction in the blood serum with definite number of exogenic hydrogen dioxide (mkmole/l) with the method of ELISA. Results. Intensification of process of lipid peroxidation has been observed at patients with metabolic syndrome —the level of lipid hydroperoxide of blood serum has been 2,9 (1,94; 3,9) mkM, antioxidant activity of blood serum has been decreased — 276,4 (239,0; 379,9) mkmole/l. In 12 months of siofor intake hydroperoxide level has been decreased till 1,1 (0,8; 1,9) mkM, but antioxidant activity has been increased and amounted 320,0 (278,9; 334,3) mkmole/l. Conclusion. Siofor has been proved to be a highly effective medicine for correction of process of lipid peroxidation and for improvement of antioxidant activity of blood serum at patients with metabolic syndrome.

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Metabolic violation of adolescents with psoriasis

Year: 2013, volume 9 Issue: №3 Pages: 574-577
Heading: Dermatovenerology Article type: Review
Authors: Materikin A.I.
Organization: Clinical dermatovenerologic dispensary of Ministry of Public Health of Krasnodarskiy krai
Summary:

This article represents a survey-analytical study of interrelationship of psoriasis and metabolic syndrome of children. The research and analysis was carried out from publications in the markers of metabolic syndrome had been explored. Much attention had been focused on population, clinical, age group and gender peculiarities of these conditions in different countries.

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Programmed cell death and processes of lipid peroxidation in metabolic syndrome

Year: 2013, volume 9 Issue: №2 Pages: 277-281
Heading: Internal Diseases Article type: Original article
Authors: Chernysheva E.N., Panova T.N
Organization: Astrakhan State Medical Academy
Summary:

The purpose: To study possible interconnection between programmed cell death and the processes of lipid peroxidation in the patients with metabolic syndrome. Material and Methods: 270 patients with metabolic syndrome at the age of 30 till 60 (162 men and 108 women) have been examined. MC diagnostic was based on the criteria recommended by experts of society of cardiologists of Russia (2009). Lipid peroxidation was estimated according to the content of hydroperoxide (mkM), the programmed cell death process was studied with protein p53 concentration determination; high sensitivity C-reactive protein content in blood serum was studied by enzyme multiplied immunoassay method (ELISA). Results: In the patients with metabolic syndrome the programmed cell death processes and lipid peroxidation are intensified. High level of lipid hydroperoxide indicates it — 2,89(1,94; 4,1) mkM and protein p53-1,59 (1,361,91) U/ ml in blood serum. Strict direct correlation between lipid peroxidation level and body weight index was defined (r+0,77, p

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Apoptosis and premature aging in patients with metabolic syndrome

Year: 2012, volume 8 Issue: №2 Pages: 251-255
Heading: Internal Diseases Article type: Original article
Authors: Chernysheva E.N., Panova T.N.
Organization: Astrakhan State Medical Academy
Summary:

The Research Objective: Correlation of apoptosis and senilism in patients with metabolic syndrome has been studied. Materials. Apoptosis inductor protein p53 concentration, insulin level in blood serum, biological age, ageing rate coefficient of 270 patients with metabolic syndrome of the age from 30 till 60 have been determined. Among them there have been 162 men and 108 women. Ageing rate coefficient and biological age have been calculated by A. G. Gorel-kin's and Pinchasov's formulae, protein p53 concentration and insulin in blood serum have been determined by enzyme multiplied immunoassay method. Results. Protein p53 concentration of the patients with metabolic syndrome has been increased and worked out 1,59 (1,361,91) U/ml, biological age, ageing rate coefficient have been increased — biological age to 6 years, ageing rate coefficient has been 1,32. Conclusion. These patients have been referred to the group with high risk of early pathology development because the processes of senilism are proleptic. The direct connection between protein p 53 and ageing rate coefficient (r+0,63, p< 0,05) and between apoptosis marker protein p53 and biological age (r+0,6, p< 0,05) have been determined.

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Characteristics study of cardiac neuropathy formation in patients with metabolic syndrome and carbohydrate metabolism disturbance (according to cardiac rhythm variability analysis data)

Year: 2011, volume 7 Issue: №1 Pages: 079-083
Heading: Internal Diseases Article type: Original article
Authors: Minakov E.V., Kudaeva L.A.
Organization: Voronezh State Medical University n.a. N.N. Burdenko, Railway Clinical Hospital ad st. Voronezh-1
Summary:

The research goal is to study the aspects of cardiac neuropathy (CN) of early formation in patients with metabolic syndrome (MS) and carbohydrate metabolism malfunction according to the data of cardiac rhythm variability analysis (CRV). Vegetative status assessment in patients with MS and glucose tolerance disturbance (GTD), MS and type 2 diabetes mellitus (DM-2) has been done relying on the investigation of CRV analysis conventional features, such as RMSSD, pNN50, new approach application based on the determination of rhythmogram short period variations (RSPV), and average rhythmogram variations (RWMV). RSPV monotony raise failure has been revealed by decrease of heart contraction rate in patients with MS and GTD, MS and DM-2. Considerable decrease of RWMV has been observed in patients with MS and DM-2. RWMV values determined within 24 hours have been diminished in the morning in patients with MS and DM-2 and normal at night. RMSSD and pNN50 features have appeared to be significantly diminished in patients with MS and DM-2, they ranging within the normal readings in patients with MS and GTD, though in the morning pNN50 values have been found at the lower tolerance. Primary and completely reversible manifestations of CN have been revealed in patients with MS and GTD; new RWMV feature has been noted to have advantages over the conventional characteristics when diagnosing the signs of CN in patients with MS and GTD

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The investigation of cardiac neuropathy formation characteristics in patients with metabolic syndrome and carbohydrate metabolism malfunction (according to the data of cardiac rhythm variability analysis)

Summary:

Aims: To study the aspects of cardiac neuropathy (CN) early formation in patients with metabolic syndrome (MS) and carbohydrate metabolism malfunction according to the data of cardiac rhythm variability analysis (CRV). Vegetative status assessment in patients with MS and glucose tolerance disturbance (GTD), MS and type 2 diabetes mellitus (DM-2) has been done relying on the investigation of CRV analysis conventional features, such as RMSSD, pNN50, new approach application based on the determination of rhythmogram short period variations (RSPV), and rhythmogram weighted-mean variations (RWMV). RSPV monotony rise failure has been revealed on decrease of the heart contraction rate in patients with MS and GTD, MS and DM-2. Considerable decrease of RWMV has been observed in patients with MS and DM-2. RWMV values determined within 24 hours have been diminished in the morning in patients with MS and DM-2 and normal at night. RMSSD and pNN50 features have appeared to be significantly diminished in patients with MS and DM-2, they ranging within the normal readings in patients with MS and GTD, though in the morning pNN50 values have been found at the lower tolerance. Primary and completely reversible manifestations of CN have been revealed in patients with MS and GTD; new RWMV feature has been noted to have advantages over the conventional characteristics when diagnosing the signs of CN in patients with MS and GTD

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Optimization of regular medical examination of patients with arterial hypertension and metabolic disorders

Year: 2010, volume 6 Issue: №2 Pages: 325-328
Heading: Internal Diseases Article type: Original article
Authors: V.V. Blinova, Yu.I. Skvortsov, A.G. Martynova, E. Yu. Ryzhkova
Organization: Saratov State Medical University
Summary:

The scientific work is devoted to examination of 180 patients with arterial hypertension in case of metabolic syndrome during the period of 12 months. By the end of initial examination patients were divided into 3 groups. The first group (72 men and women) was regularly checked by cardiologist once in 3 months, the second one (60 patients) -once in 6 months, the third group (48 patients) was observed once a year. Accordingly regular clinical examination provides more effective conditions for observation and treatment, improvement of health state and hemodynamic indices allowing to cosider the given way of clinical examination as a rational and effective method

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PECULIARITIES OF GESTASION IN PREGNANT WOMEN WITH METABOLIC SYNDROME

Year: 2007, volume 3 Issue: №3 Pages: 62-64
Heading: Obstetrics and Gynecology Article type: Original article
Authors: R.R. Berihanova, G.I. Khripunova
Organization: Saratov State Medical University
Summary:

The article presents the peculiarities of gestasion in pregnant women with metabolic syndrome. The obtained findings testify that metabolic syndrome is a factor of high risk in the development of gestosis, fetoplacental insufficiency and another obstetrical complication.

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METABOLIC SYNDROME X - PANDEMIC OF THE XXI CENTURY

Year: 2008, volume 4 Issue: №3 Pages: 130-134
Heading: Internal Diseases Article type: Review
Authors: Т.D. Kolopkova, V.V. Blinova, Yu.l. Skvortsov, V.G. Subbotina
Organization: Saratov State Medical University
Summary:

A survey of data found in scientific articles including the main points, structure, spreading and social importance of metabolic syndrome X as a real predictor of mortality level are presented. The genetic mechanism of insulin resistance and arterial hypertension are revealed. The role of obesity in metabolic syndrome’s forming is discussed.

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