Saratov JOURNAL of Medical and Scientific Research

Rogozhina I.E.

Saratov State Medical University n.a. V. I. Razumovsky, Head of Department of Obstetrics and Gynecology, Professor, DSc

Serotonin system in premenstrual syndrome occurrence

Year: 2016, volume 12 Issue: №2 Pages: 136-138
Heading: Obstetrics and Gynecology Article type: Review
Authors: Rogozhina I.E., Ignatova M.B.
Organization: Saratov State Medical University
Summary:

The review presents the published data on relevance of problem, frequency rate and the mechanisms of occurrence of premenstrual syndrome, the necessity of complex treatment of premenstrual syndrome has been proved.

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Effect of estrogen deficiency on the lipid profile in women in different age periods

Year: 2014, volume 10 Issue: №3 Pages: 396-400
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Neyfeld I.V., Rogozhina I.E., Kirichuk V.F., Kiselev A.R., Zhirnyakov A.l., Bobyleva I.V.
Organization: Saratov Institute of Cardiology, Russia, Saratov State Medical University
Summary:

The aim of the study is to evaluate influence of estrogen deficiency on lipid profile in women of different age. Material and Methods. 189 women with normal body weight: 44 women with premature menopause (aged <40 years), 69 women with early menopause (aged 40-45 years), and 76 women with natural menopause (aged 46-55 years) have been studied. In all women identification of clinical status has been performed during clinical examination. Results. It is shown that increasing age associated with increasing total cholesterol, triglycerides, low-density lipoprotein (LDL), very low density lipoproteins (VLDL) (p<0.05). We have not observed a significant association between age and level of high-density lipoprotein (HDL) (p=0.117). According with increased age, atherogenic index of plasma (AIP) increases from initial -0.17±0.09 (M±o) to 0.09±0.47 (p<0.05) in women with premature menopause, and to 0.14±0.21 (p<0.05) in other women. Final level of AIP was similar between women aged 40-45 years and women aged 46-55 years (p=0.084). Conclusion. Lipid metabolism disorders were assessed in 73.5% of women with estrogen deficiency. According to the age factor the rate of women with normal lipid metabolism decreases (x2=10,165, p=0.026).

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Alterations in venous blood flow of lower uterus segment and cervix of uterus at physiological course of preliminary period

Year: 2012, volume 8 Issue: №3 Pages: 729-733
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Chekhonatskaya М.L, Yannaeva N.£., Grishaeva L.A., Rogozhina I.£., Prodanova E.V., Bakhmach V.O.
Organization: Perinatal Centre, Saratov , Saratov State Medical University
Summary:

Research objective. The objective of this research is the study of venous blood flow parameters of lower uterus segment and cervix of uterus at the physiological course of preliminary period. Material and methods. The study was based on the investigation of the course of preliminary period of 90 patients with physiological delivery at term. Results. There is a growing rate of venous blood flow of lower uterus segment and cervix of uterus at rest as well as at peak of contractions. Conclusion. Veins are transformed into structures similar to lacunae at the physiological course of preliminary period. There is a growing rate of venous blood flow of lower uterus segment and cervix of uterus which results in blood storage and seems to be one of the mechanisms leading to cervical dilatation.

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Risk factors of intestinal obstruction in pregnancy

Year: 2012, volume 8 Issue: №3 Pages: 723-728
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Khvorostukhina N.F., Salov I.A., Rogozhina I.E., Stolyarova U.V.
Organization: Saratov State Medical University
Summary:

Objective: to study risk factors and options for clinical course of acute intestinal obstruction in pregnancy. Materials and methods. A detailed study of history, clinical course, diagnosis and treatment characteristics of acute intestinal obstruction in 79 pregnant women was undertaken. Results: It was determined that a combination of intestinal obstruction, and pregnancy is more common for II and III trimester of gestation (88,5%), with more likely to develop mechanical obstruction caused by the adhesive process (77,2%). Risk factors for intestinal obstruction in pregnancy are: chronic diseases of gastrointestinal tract, surgery of abdominal cavity and pelvis, burdened obstetric and gynecological history and long-term use of progestogens during pregnancy. Difficulties in diagnosis are associated with absence of classical symptoms of disease that is caused by changes in topographical relations of abdominal cavity, increasing size of uterus, as well as lack of immune response to the emergence of a pathological process. Conclusion. Formation of pregnant women at risk for development of intestinal obstruction and preventive measures to address violations of intestinal motor function can reduce the risk of disease. Algorithm of medical tactics for suspected acute intestinal obstruction in pregnancy, allowing to reduce time of diagnosis and provision of medical care.

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Principal causes and ways of prevention of early reproductive losses

Year: 2011, volume 7 Issue: №3 Pages: 593-598
Heading: Obstetrics and Gynecology Article type: practicing physician
Authors: Tebelev В. G., Rogozhina I.E.
Organization: Saratov State Medical University
Summary:

The literature on principal causes of early abortions and ways of treatment in the first trimester was studied. Reproductive losses in the first trimester were found out to be the most active because of 5 main groups of reasons. In each group the therapeutic way of abortion was considered

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Lowinvasive technologies and hemostasis system at a hysteromyoma

Year: 2011, volume 7 Issue: №3 Pages: 587-592
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Rogozhina I.E., Khvorostukhina N.F.
Organization: Saratov State Medical University
Summary:

Research objective. Study of condition of hemostasis system at patients with hysteromyoma complicated by bleeding; comparative estimation of hemostasis indicators at patients with uterine arteries embolization (the basic group n=48) and abdominal hysterectomy (comparison group n=65). Materials and methods. Complex study of the basic hemogram parameters and hemostasis at 162 patients with hysteromyoma and 30 patients without marked genital pathology (the II control group) was carried out. 48 patients formed the main group which was subjected to uterine arteries embolization for bleeding break; 65 patients (the comparative group) were surgically operated upon abdominal hysterectomy; 49 patients with hysteromyoma had no bleedings and formed the control group. Research of hemostasis system was carried out by means of test-tube method, and also by plotting set for express-diagnostics, analysis of thrombocyte unit of hemostasis system was realized with 2-channel analyzer of thrombocyte aggregation «Biola» — LA 230. Results. Presented analysis of hemostasiogram parameters allows to state development of chronic DIC-syndrome in women with hysteromyoma. Reliable shortening of coagulation index, decrease of thrombocyte aggregation function in comparison to the control group data were revealed. Conclusion. Development of hyper coagulation with increase of paracoagulative products with simultaneous activation of fibrinolysis processes in all the patients with hysteromyoma was revealed. Minimal effect of embolization of uterine arteries to hemostasis system in patients with hysteromyoma was marked. And they were intensified after surgical treatment, which is the evidence of definite advantages of this method unlike of hysterectomy

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Gestational diabetes mellitus: risk factors development, occurrence, diagnostics and treatment (review)

Year: 2011, volume 7 Issue: №2 Pages: 534-541
Heading: Endocrinology Article type: Review
Authors: Kostenko I.V., Rogozhina I.E., Sukhankina G.V., Ryzhkina S.A.
Organization: Saratov State Medical University, Engels Perinatal Centre
Summary:

Gestational diabetes is defined as a violation of carbohydrate metabolism resulting in hyperglycemia of varying severity, firstly revealed or developed during the pregnancy. The article presents current data on the occurrence, etiology and pathogenesis of gestational diabetes, as well as methods for screening and diagnostics of disorders of carbohydrate metabolism during pregnancy. It explains the basic principles of diet therapy

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Modern review of pathogenesis of urgent uterine bleedings in obstetrical and gynecological practice

Year: 2011, volume 7 Issue: №1 Pages: 059-065
Heading: Obstetrics and Gynecology Article type: Review
Authors: Rogozhina I.E.
Organization: Saratov State Medical University
Summary:

The article presents modern data concerning mechanisms of uterine bleedings in undeveloped pregnancy, hystero-myoma, and cervical carcinoma. Hemostasis system malfunctions appeared in case of dead foetus in uterus have been considered in the work. They are manifested by consumption coagulopathy and haemorrhagic complications. Uterine bleedings in case of hysteromyoma are caused by dilation of arterial vessels and deprivation of their contractile function and malfunction myometrium contraction. Complications that occur in oncological uterine bleedings arrest have been described. They are caused by individual uterine blood supply and developed network of collateral anastomoses between branches of internal iliac arteries

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State of newborns according to prenatal iodine intake

Year: 2011, volume 7 Issue: №1 Pages: 049-052
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Kurmacheva N.A., Naumova Yu.V., Rogozhina I.E.
Organization: Saratov State Medical University, Saratov Regional Centre of Family Planning and Reproduction
Summary:

Comparison analysis of the state of newborns in the conditions of the absence of prenatal iodine prevention (group 1); irregular receiving inadequate preventive doses of iodine-containing drugs (group 2); adequate prenatal iodine prevention (group 3) has been carried out. It is shown that only an adequate consumption of iodine by pregnant women (at least 250 ug of potassium iodide per day) can significantly reduce the frequency of neonatal disorders of adaptation (in 2,3-2,5 times), disharmonious physical development (in 2,5-2,8 times), perinatal encephalopathy (in 1,5-1,7 times), acute infectious diseases (in 1,5-1,6 times) and neonatal hyperthyreotropinemia (in 4,2-9,4 times)

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Prospects of application of normobaric hypoxic interval training in treatment of placental insufficiency (literature review)

Year: 2010, volume 6 Issue: №3 Pages: 543-549
Heading: Obstetrics and Gynecology Article type: Review
Authors: I.E. Rogozhina, G.E. Makhova, E.V. Prodanova
Organization: Saratov State Medical University
Summary:

Placental insufficiency represents a syndrome of multifactorial etiology caused by morphological and functional changes in placenta, leading to disturbances in growth rates and development of fetus. Fetoplacental insufficiency is the leading factor in occurrence of fetal hypoxia, arrested development of fetus, traumas during delivery, diseases and complications in postnatal period. Placental insufficiency development is accompanied by disorders in differentiation and extension placental villi. Also processes of angiogenesis are affected. As a result there is a transport, respiratory, trophic, endocrinal and protective dysfunction of placenta. In fetal organism universal adaptative reactions directed on maintenance of homeostasis arise. Application of interval hypoxic therapy is directed on «training» of fetal adaptative mechanisms to hypoxia. Good tolerance of 10% О - gas mix has been revealed. High therapeutic effect is shown by increase in functional reserves of cardio-respiratory system, normalization of acid-base balance, normalization of arterial pressure, mobilization mechanisms of regulation of hypothalamic-pituitary adrenocortical system that results in increase of general resistance of fetus to hypoxia

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