Saratov JOURNAL of Medical and Scientific Research

Glybochko P.V.

Saratov State Medical University, Rector, RAMS Corresponding Member, Director of Saratov Research Institute for Fundamental and Clinical Urology and Nephrology, Professor, Doctor of Medical Science

Improvement of complex therapy of patients with pathology of scrotal organs formed by chronic brucellosis infection

Year: 2013, volume 9 Issue: №2 Pages: 165-170
Heading: Infectious Diseases Article type: Original article
Authors: Glybochko Р. V., Evdokimov A.M., Liapina Е.Р., Shuldiakov A. A., Ponukalin A.N., Blyumberg В.I., Sedova L.N.
Organization: First Moscow State Medical University n.a. I.M. Sechenov, Saratov State Medical University
Summary:

The aim of the study is to improve the treatment of patients with male reproductive organs pathology, formed by chronic brucellosis infection. Material and methods: We have analyzed the dynamics of the clinical manifestations of diseases of the scrotal organs, data of physical and ultrasound studies, semen parameters, the quality of life in 22 patients with chronic brucellosis and the presence of orchitis / orchiepididymitis against conventional therapy (10 patients), and combined treatment with the inclusion of cycloferon (i/m, 2 injection rate from 5 (0.25g) with a break 10 days) — 12. Results: We have proved ability of cycloferon to reduce the severity of the inflammatory process in the testis and epididymis, with improving of spermatogenesis and the quality of life for patients. We have marked the reduction in the number of exacerbations of chronic orchitis / orchiepididymitis 2.4 times after the course of cycloferon, its good tolerability of patients, no side effects. Conclusion: Using these results, the presence of anti-inflammatory and immunomodulatory potencies, cycloferon can be recommended in treatment of inflammatory lesions of the scrotal organs in patients with chronic brucellosis.

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Dynamics of lower urinary tract of a fetus in intrauterine development retardation

Year: 2011, volume 7 Issue: №2 Pages: 513-517
Heading: Urology Article type: Original article
Authors: Glybochko Р.V., Chekhonatskaya M.L., Piskunova L.V.
Organization: Saratov State Medical University, First Moscow State Medical University n.a. I.M. Sechenov
Summary:

The research goal is to study and analyze the relationship between the level of intrauterine development retardation and urine dynamics indicators of lower urinary tract of a fetus with the help of ultrasonic examination. The urinary function of 89 fetuses was under study. Methods of prenatal ultrasonic cystometry and urofluometry were used to examine the urinary function of a fetus. Statistical software package (Statgraphics 6.0) was used for the statistical analyses of the results. The study has shown that decrease in bladder capacity, increase in residual urine volume and frequent urination are usually the indicators of intrauterine development retardation. The third-degree of intrauterine development retardation is characterized by decrease in diuresis and increase in duration of micturition cycle according to gestational norm

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Opportunities of radiological methods for examination in diagnostics of urinary bladder cancer

Year: 2011, volume 7 Issue: №1 Pages: 148-151
Heading: Urology Article type: Review
Authors: Glybochko P.V., Zuev V.V., Popkov V.M., Chekhonatskaya M.L, Ponukalin A.N.
Organization: Saratov State Medical University, First Moscow State Medical University n.a. I.M. Sechenov
Summary:

The research goal is the comparative analysis of Russian and foreign studies concerned the possibility of radiological methods of diagnostics of cancer of urinary bladder. The problem of early diagnostics of initial tumor and tumor recurrence, determination of stages of bladder cancer, its prognosis and outcome remains an actual one

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The differential approach to estimation of renal damage in the patients with nephrolithiasis by means of noninva-sive markers

Year: 2010, volume 6 Issue: №3 Pages: 708-715
Heading: Urology Article type: Original article
Authors: Rossolovsky A.N., Glybochko P.M., Popkov V.M., Polozov A.B., Ponukalin A.N., Zakharova N.B., Berezinetz O.L., Blumberg B.I.
Organization: Saratov State Medical University, Saratov State Cardiosurgical Centre, First Moscow State Medical University n.a. I.M. Sechenov
Summary:

The aim of this study was the estimation of clinical importance markers of renal damage at surgical treatment of nephrolithiasis. We studied results of operations in 110 patients with nephrolithiasis. The study presents new candidates for biochemical markers of acute kidney injury and renal interstitial fibrosis, with potentially high sensitivity and specificity. In this study were measured the concentrations of these biomarkers in urine. We suggested, that increased concentrations molecular mediators of renal damage (L2, IL-18) and interstitial fibrosis (MCP-1, TGFp, IGF1) in the patients with nephrophibrosis and strongetubulointerstitial injury, saved long-time period after operation, has been shown of progression chronic kidney disease

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Comparative analysis of data of clinical, laboratory and radiation diagnostic techniques of prostate cancer with histomorphological tumor gradation by Gleason scale

Year: 2010, volume 6 Issue: №2 Pages: 446-453
Heading: Urology Article type: Original article
Authors: P.V. Glybochko, T.G. Hmara, V.M. Popkov, M.L. Chekhonatskaya, G.N. Maslyakova, V.N. Priezsheva, A.N. Ponukalin
Organization: Saratov State Medical University, First Moscow State Medical University n.a. I.M. Sechenov
Summary:

In scientific article the research goal is the comparative analysis of data of clinical, laboratory and radiation diagnostic techniques of prostate cancer with histomorphological tumor gradation by Gleason scale. the level of prostate-specific antigen (PSA) and index PSA D depend on parameters on Gleason scale. Ultrasonic findings are correlated with histomorphological gradation of adenocarcinoma. Magnetic-resonance imaging is effective only with 8-10 points on Gleason scale. In the research 217 patients with suspecting prostate cancer have been included. As a result prostate cancer has been diagnosed in 157 (72,4%) patients, prostate adenoma - in 60 (27,6%) patients

Causative agents of urinary tracts infection in children with obstructive uropathy

Year: 2010, volume 6 Issue: №2 Pages: 442-446
Heading: Urology Article type: Original article
Authors: P.V.Glybochko, A.A. Svistunov, O.L. Morozova, D.A. Morozov, S.A. Scherbakova, E.S. Kazakova, I.A. Kasjan
Organization: First Moscow State Medical University n.a. I.M. Sechenov, Russian Research Anti-Plague Institute «Microbe», Saratov State Medical University
Summary:

167 children with different variants of congenital obstructions of urinary tracts were examined; the causative agents of urinary tracts infections were analyzed in all the cases. The changes of the cytokines levels were determined in those patients which had the more often found causative agents in the analyses. It was mentioned that of the total patients with obstructive uropathy (OU) the fifth part in the absence of bacteriuria had a pathogen in biopsy material (BM) of urinary tracts. In fourth part of cases microorganisms that were detected in BM and urine did not matched. The changes of cytokines levels in urine did not have any species-specific dependence on causative agent

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Comparative analysis of perioperative period in children with different corrections of vesicoureteral reflux

Year: 2010, volume 6 Issue: №1 Pages: 182-188
Heading: Urology Article type: Original article
Authors: P.V. Glybochko, A.A. Svistunov, O.L. Morozova, D.A. Morozov, B.V. Dolgov, F.K. Napolnikov
Organization: Saratov State Medical University
Summary:

The article presents the analysis of perioperative period of 52 children with different variants of correction of vesicoureteral reflux. It was based on acute-phase proteins amount, cytokines level and adhesion molecules content in blood and urine. the study revealed that if the correction is performed during the latent phase of chronic obstructive pyelonephritis the preference should be given to the endoscopic operations as they do not lead to acute inflammatory process in the urinary tract

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The prenatal verification of the obstructive uropathy at the fetal

Year: 2010, volume 6 Issue: №1 Pages: 173-178
Heading: Urology Article type: Original article
Authors: M.L. Chekhonatskaya, P.V. Glybochko, N.U. Arenina, L.V. Piskunova, M.M. Grigorieva
Organization: Saratov State Medical University, Saratov Clinical Hospital №3
Summary:

The research goal is to study functional condition of upper and lower urinary tracts at fetus with obstructive uropathy and development of differential diagnostic and prognostic criteria of transition of functional disorders to organic.
The diagnosis of prenatal and verified postnatal obstructive uropathy at 42 fetuses has been made by prenatal ultrasonic cystometry. Process of filling and evacuation of bladder has been under study. Obtained data have been compared with the results of dynamic measurement of kidney sizes in a standard projection.
According to the results only at 19,1% of cases statistically significant urodynamic differences have not been revealed in comparison with control group. Diagnostic accuracy of organic form of urodynamic obstructions is 84%, of functional in 64,7% of observations and in 52,9% of cases the infection of urinary tracts with incomplete evacuation of bladder has been diagnosed.
The degree of kidney and ureter expansion is not a differential diagnostic criterion of organic or functional urodynamic obstructions. However, using a principle of estimation of upper and lower urinary tracts condition, it is possible to make a prenatal differential diagnosis of variants of defects

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State of renal hemodynamics and nephrofibrosis parameters in patients with nephrolithiasis applying angiotensin converting enzyme inhibitors

Year: 2010, volume 6 Issue: №1 Pages: 170-173
Heading: Urology Article type: Original article
Authors: P.V. Glybochko, A.A. Svistunov, A.N. Rossolovsky, O.L. Berezinetz, N.B. Zakharova, A.P. Abramova
Organization: Saratov State Medical University, Saratov State Cardiosurgical Centre
Summary:

The aim of the study is to evaluate the influence of angiotensin converting enzyme (ACE) inhibitors of quinapril on the condition of renal hemodynamics, changes of profibrotic cytokines level and transforming growth factor at patients with nephrolithiasis undergone various kinds of surgery. Patients were divided into 2 groups initially and in 1 month after surgery. Concentrations of IL-6, TGFp and МСР-1 were determined in blood serum. Assessment of renal blood flow state by Doppler ultrasonography was performed in the same terms. As a result of quinapril treatment the decrease of МСР-1, TGFp and IL-6 was marked in comparison with the group which did not receive nephroprotective therapy. The analysis of Doppler ultrasonography data showed authentic improvement of renal blood flow in 1 month after surgery. The most informative parameter proved to be the resistance index that indicated the decrease of vascular resistance after surgical treatment in condition of quinapril therapy

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Neuroendocrine aspects of prostate oncogenesis

Year: 2010, volume 6 Issue: №1 Pages: 164-170
Heading: Urology Article type: Review
Authors: P.V. Glybochko, V.M. Popkov
Organization: Saratov State Medical University
Summary:

The prostate cancer is a widespread disease in Russia with high growth rate and high death rate. Active work in discovery of methods of early diagnostics of prostate cancer is carrying out. it will allow to increase considerably the efficiency of treatment. the data on topography, structural and functional organization, physiology and regulatory effect of neuroendocrine cells and neuroendocrine hormones and peptides of prostate produced by neuroendocrine cells are presented in the review. Neuroendocrine mechanisms of development, prospects of early diagnostics and prognosis of prostate cancer are analyzed

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