Saratov JOURNAL of Medical and Scientific Research

Sholomov I.I.

Saratov State Medical University, Head of Department of Nervous System Diseases, Professor, Doctor of Medical Science

Application NO TGCH-therapy in complex treatment of postoperative lumbar localization radiculopathy

Year: 2011, volume 7 Issue: №4 Pages: 884-887
Heading: Neurology Article type: Original article
Authors: Fomina A.V., Ablyaev l.l., Lyubitsky l.P., Bugaeva I.О., Sholomov l.l., Salina E.A.
Organization: Saratov State Medical University, Saratov Clinical Hospital №3
Summary:

This paper presents the results of a survey of 50 patients to study the application of terahertz therapy of NO in the complex treatment of postoperative lumbar radiculopathy localization. Materials and methods. Using a visual analogue scale assessed the degree of regression of pain, depending on the nature of the therapy. For the diagnosis of intra-articular inflammation in the postoperative motor segment and a local mikrovaskulita determined the level of antibodies in the serum of patients to collagen and myeloperoxidase. The results suggest shortening pain and reducing the content of antibodies to MPO and collagen in patients receiving short-wave therapy. Therefore, we conclude that the use of NO therapy TGCH improves the treatment of postoperative lumbar radiculopathy localization

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Screening methods in assessment of cognitive functions for neurosyphilis early diagnostics

Year: 2011, volume 7 Issue: №4 Pages: 879-884
Heading: Neurology Article type: Original article
Authors: Kolokolov О.V., Bakulev A.L, Sholomov I.I., Popovicheva О.A., Belousov М.I., Branova М.А., Abramova Т.P.
Organization: Saratov State Medical University
Summary:

The aim of the study: To examine the sensitivity of mini-mental state examination (MMSE) and clock drawing test (CDT) in screening of cognitive function in patients with syphilis. Materials and methods A total of 1387 patients with different forms of documented neurosyphilis were examined to study the deficiency of neurological function. The diagnosis of neurosyphilis was confirmed by CSF-study. In 75 cases cognitive function was studied by MMSE and clock drawing test. Results: MMSE and clock drawing test showed cognitive dysfunction in 76,4% of patients with syphilis. The sensitivity of both tests was rather equal. Such tests could be made in a short time and are simple in understanding. Thus these tests could help in the everyday practice of dermatologists and neurologists as screening methods of cognitive dysfunction in patients with syphilis. Conclusion: The results of screening tests in patients with significant cognitive dysfunction could be used in the early diagnostics and corresponding treatment of neurosyphilis

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Epidemiology of neurosyphilis in the Saratov region

Year: 2011, volume 7 Issue: №3 Pages: 653-657
Heading: Neurology Article type: Original article
Authors: Kravchenya S.S., Kolokolov O.V., Bakulev A. L, Sherstobitova LA., Sholomov I.I., Branova M.A., Zhukovskaya A.U.
Organization: Saratov State Medical University
Summary:

The research goal is to evaluate the epidemiology of syphilis and neurosyphilis in the Saratov region science 1994 till 2010. Materials and methods: The forms of statistical inquiry in the Saratov region have been studied. The results of syphilis blood tests were examined in neurological departments of Saratov hospitals. Results: The tendency to reduction of syphilis morbidity was revealed in the Saratov region while the incidence of neurosyphilis increased. Severe forms of symptomatic neurosyphilis were predominant. In spite of increasing number of positive syphilis serological tests in neurological hospitals of Saratov the detection of neurosyphilis among neurological patients remained low. Conclusion: Neurosyphilis has become a common disease in the Saratov region. The issues of diagnostics and treatment of neurosyphilis should be considered by close cooperation between dermatologists and neurologists

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Possibilities of magnetic resonance tomography in identification and diagnostics of neurosyphilis forms

Year: 2011, volume 7 Issue: №3 Pages: 647-652
Heading: Neurology Article type: Original article
Authors: Kolokolov O.V., Bakulev A.L., Zuev V.V., Sholomov I.I., Chekhonatskaya M.L, Kolesnikov A.I., Tikhonova LA., Starodubova A. V.
Organization: Saratov State Medical University
Summary:

Aim: To evaluate the possibilities of the magnetic resonance tomography (MRT) in diagnostics and identification of neurosyphilis. Materials and methods: A total of 1387 patients with different forms of documented neurosyphilis were examined to study the deficiency of neurological function. The diagnosis of neurosyphilis was confirmed by CSF-study. MRT was performed in 57 cases. Results: Magnetic resonance tomography (MRT) in 6 patients showed no pathology, 16 patients had arachnoid cystic changes and in 16 cases hydrocephaly occurred. Cerebral cortical atrophy was presented in 13 patients, in 12 cases — multifocal changes were visualized, 12 patients had white matter structural changes. Two cases required diagnostics. A 59-year-old man was hospitalized with epileptic seizure, progressive dementia and multifocal neurologic symptoms. A 40-year-old man was examined with recurring episodes of acute cere-brospinal accident and progressing cognitive disorders. Conclusion: MRT could be used in differential diagnostics of neurosyphilis imitating space-occupying lesions of cerebrum and spinal cord, tumors of central nervous system and could help to define the form of neurosyphilis

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Evaluation of risk factors of infantile cerebral paralysis development in disabled children

Year: 2011, volume 7 Issue: №2 Pages: 446-450
Heading: Neurology Article type: Original article
Authors: Alekseeva G.Yu., Sholomov I.I.
Organization: Saratov State Medical University
Summary:

Research object: to detect the influence of qualitative and quantitative factors involved into ICP formation. Material: the research is based on the clinical observation, instrumental diagnostics and 147 disabled children with ICP aged under 4 rehabilitation campaign results analysis. Comparison group was composed from 39 children of similar age who were registered for observation by pediatric polyclinics neurologists and were rehabilitated. Results: 2 algorithms formed as decision trees, that were built using multivariate analysis methods were suggested and can be used in pediatric polyclinics for children with ICP formation threatening detection. Conclusion: the ICP formation can be forecasted in 93% of cases wrt prematurely born children with convulsive and hypertensive-hydrocephalic syndromes in aggregate with periventricular leukomalacia

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Advanced methods of treatment of hypophysis adenoma

Year: 2011, volume 7 Issue: №1 Pages: 112-114
Heading: Neurology Article type: Review
Authors: Zhestikova M.G., Kan Ya.A., Sholomov I.I.
Organization: Saratov State Medical University, Novokuznetsk State Medical Institute for Advanced Training of Physicians, Novokuznetsk State Clinical Hospital № 1
Summary:

Hypophysis adenomas are mostly spread in the chiasmatic cellular area. They account 18% of all new brain formations, the structure of pituitary adenomas includes prolactinomas in a large number of cases which are manifested by the syndrome of hyperprolactinemia and hormone inactive hypophysis tumours (35%). Somatotropins (13-15%) are lower in frequency, the main clinical feature is acromegalia. One can rarely reveal corticotropins (8-10%), gonadotro-pins (7-9%) and thyrotropins (1%) and their mixed forms. Transsphenoidal surgical interventions are considered to be methods of choice treatment of hypophysis adenomas and other formations in the chiasmatic cellular area. Alternative methods of treatment are conservative. They can be as an addition to microsurgery (radiotherapy)

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Structural and clinikal displays of discogenic radiculopathy in combination with haemangioma of spine

Year: 2010, volume 6 Issue: №4 Pages: 803-806
Heading: Neurology Article type: Original article
Authors: Fomina AM, Bugaeva I.O., Salina E.A., Sholomov I.I.
Organization: Saratov State Medical University
Summary:

The work presents the examination results of 104 patients with the symptoms of lumbosacral compressive radiculopathy. The intensity of pain syndrome at rest, in physical exertion and at night was assessed by visual analogue and verbal assessment scales. Magnetic resonance tomography was used to examine the condition of vertebral bodies, degenerative changes of invertebral discs and the size and location of invertebral disc extrusion. The results of the study has led to the conclusion that disc syndrome in combination with spinal hemangioma is accompanied in most cases by lower limb chronic venous insufficiency, urination disorders and has no direct influence on pain intensity

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Neurosyphilis: problems of diagnostics and classification

Year: 2010, volume 6 Issue: №3 Pages: 632-636
Heading: Neurology Article type: Review
Authors: Kolokolov O.V., Sholomov I.I., Bakulev A.L., Kravchenya S.S., Kolokolova A.M.
Organization: Saratov State Medical University
Summary:

The study involved 1315 patients with various forms of syphilis. In 282 patients neurosyphilis was diagnosed. The detailed description of clinical picture of disease and the results of laboratory studies are given. Questions of tactics of medical examination, modern classification of neurosyphilis forms are discussed. The actions are discussed, allowing to increase probability of a favorable outcome of disease

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Peculiarities of psychovegetative status of preg¬nant women with fetoplacental insufficiency in condition of delivery preparation by means of biologically feedback method

Year: 2010, volume 6 Issue: №2 Pages: 295-300
Heading: Obstetrics and Gynecology Article type: Original article
Authors: T.Yu. Kipchatova, N.Yu. Arenina, M.L. Chekhonatskaya, I.I. Sholomov
Organization: Saratov State Medical University, Saratov Clinical Hospital №3, Saratov Clinical Hospital N 8
Summary:

Research goal. To study peculiarities of psychovegetative status of pregnant women with fetoplacental insufficiency in condition of delivery preparation by means of biologically feedback method.
Materials and methods. 56 pregnant women with chronic fetoplacental insufficiency took drug therapy along with biologically feedback method (BFM), 24 patients didn't undergo seances of bioregulation. Therapeutic results were evaluated after 2-4 weeks of BFM.
Results. Probability of chronic fetoplacental insufficiency progress in the absence of BFM-therapy was 32,8%; after seances of bioregulation - 11,3%. Use of BFM-therapy for women with chronic fetoplacental insufficiency promotes normalization of psychovegetative status and decreases probability of this pathology progress by 21,5%.
Conclusion. BFM-therapy had maximum efficacy in its day-time conduct. After day-time seances 71,2% of positive results was revealed; in evening - 44,6%; in morning - 56,3%. In day-time BFM-therapy seances 11,6% of unsatisfactory results was marked; while morning and evening seances recognized 18,9% and 23,4% accordingly

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Diagnostics And Treatment Of Patients With Blood Circulation Insufficiency In Vertebrobasilar Bed

Year: 2009, volume 5 Issue: №4 Pages: 629-634
Heading: Surgery Article type: Original article
Authors: R.Z. Losev, V.N. Nikolenko, I.I. Sholomov, A.M. Khachatryan
Organization: Saratov State Medical University
Summary:

For improvement of treatment results of patients with vertebrobasilar insufficiency we have analyzed data of medical examination and treatment of 182 patients stayed in clinics of Hospital Surgery and Nervous System Diseases from the 1st of January of 2005 till the 30th of June of 2009. Method of screening diagnostics, quantitative and qualitative blood flow estimation by means of Doppler ultrasonic investigation and angiography have been performed. The cause of blood circulation insufficiency in the vertebrobasilar bed at 87 patients was vertebral artery syndrome and in 95 cases there were the significant hemodynamical damages of blood flow in aorta arch branches and intracranial arteries. The neuroangiotropic therapy has been made for all patients, but the clinical improvement period was short in most cases, more prolonged effect was observed in addition of conservative therapy with plasmapheresis by indications. In the complex treatment of patients with vertebrobasilar insufficiency accompanied by degenerative diseases of spine chemical sympathectomy of vertebral artery in the III segment in the form of procaine and spirit-procaine blockades was made in 116 and 69 cases accordingly. The surgical sympathectomy was made in 15 patients. The surgical operations were made in 62 of 95 patients with significant hemodynamic pathology of blood flow in the vertebrobasilar region. In most cases isolative and combinative reconstructive surgery on carotid arteries was carried out. It played a significant role in blood flow correction. Favorable postoperative results were observed in most cases (93, 5%)

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