Saratov JOURNAL of Medical and Scientific Research

Tereshkina N.E.

Saratov State Medical University n.a. VI. Razumovsky, Senior Research Assistant, Candidate of Medical Science

Diagnostic value of bio-markers in the prognosis of postoperative relapses and metastases in patients with breast cancer

Year: 2017, volume 13 Issue: №2 Pages: 239-244
Heading: Oncology Article type: Original article
Authors: Cheburkayeva M.Yu., Zakharova N.B., Fedorov V.E., Teryoshkina N.E., Gergenreter Yu.S.
Organization: Regional Oncology center №2, Saratov State Medical University
Summary:

Purpose: to improve the diagnosis of relapse and metastasis of breast cancer in the postoperative period. Material and methods. 123 women were examined. Of these, 30 practically healthy women made up a control group, 20 women had benign breast diseases, 73 had breast cancer. The patients with ВС before the surgical intervention were divided into groups according to the stage of the disease. The 1st group consisted of 30 practically healthy women. In the second group — 20 women with fibroadenomas of the breast. In the third group — 33 women with l-ll stages of breast cancer without regional metastases. The 4th group consisted of 22 women with stage II breast cancer with regional metastases, in the 5th group — 18 patients with stage III breast cancer. After surgery, 68 patients were re-examined and divided into 2 analytical groups. The 6th group included women without clinical manifestations of relapses and metastases in the postoperative period — 44 (64.7%). Group 7 consisted of 24 (35.3%) women who had metastasis and local recurrences of the disease in the postoperative period. To determine the content of fetal proteins (Ca-15-3, Ca-125, REA), IL-8 and VEGF, commercial sets of reagents for solid-phase enzyme-linked immunosorbent assays were used. Results. Analysis of the data obtained showed that the most significant increase in serum and plasma VEGF levels occurred in breast cancer patients with clinical signs of metastasis and recurrence of the disease. Of fetal proteins, a significant increase in blood content showed Ca15-3 and CEA. Conclusion. We can assume that in patients with breast cancer only in the postoperative period, the rise in VEGF was associated with the growth of tumor tissue and the development of invasion and metastasis.

AttachmentSize
2017_02_239-244.pdf516.97 KB

The value of composition and cytokine activity of wound discharge cells in patients with acute odontogenic inflammatory diseases of the maxillofacial region

Year: 2015, volume 11 Issue: №2 Pages: 173-177
Heading: Stomatology Article type: Original article
Authors: Lepilin A.V., Zakharova N.B., Fedotenkova D.A., Tereshkina N.E.
Organization: Saratov State Medical University
Summary:

Purpose: to establish the diagnostic value of the immune cells composition and cytokine activity of the cells in wound discharge from patients with acute odontogenic inflammatory diseases of maxillofacial region. Materials and methods. A total of 31 patients with acute odontogenic inflammatory diseases of maxillofacial region were examined. The number of immune cells and pro-inflammatory cytokines content (IL1(3, MCP1, IL6, IL8, TNFa) in the wound discharge were determined. Results. It has been established that depending on the severity of the inflammatory process in maxillofacial region the immune cells composition and levels of pro-inflammatory cytokines are changing. Conclusion. Determination of the immune cells composition and level of cytokines in the wound discharge can be used for estimation of the character and severity of acute odontogenic inflammatory processes in the maxillofacial region.

AttachmentSize
2015_02_173-177.pdf535.41 KB