Saratov JOURNAL of Medical and Scientific Research

irradiation

Cytogenetic examination in remote period after the stay in the Semipalatinsk nuclear test site area

Summary:

Aim: retrospective cytogenetic indication of doses probably received by individuals during the residence in the region of the Semipalatinsk nuclear test site, at work or service in the Armed Forces on it. Material and methods: the analysis of chromosomal aberrations in peripheral blood lymphocyte cultures of 16 people с using FISH-method. Re-sults. The frequencies of FISH-registered translocations were not significantly different from control values in 7 out of 16 cases; the dose evaluations ranged from 0.20 to 0.75 Sv for the remaining 9 persons. Conclusion. FISH-technique of chromosome aberration analysis allows to make retrospective dose assessment; however it is desirable simultaneously to produce classical analysis also for a more correct interpretation of the results; Detection of single multiaber-rant cells in peripheral blood lymphocyte cultures is characteristic of persons who were in the areas of alpha-emitting radionuclide pollution, what is allowed to talk about radiation damage, but does not allow to make dose assessment.

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2015_04-01_620-624.pdf319.61 KB

Cytogenetic examination of persons working in the area of radiation accident at the Fukushima-1 NPP in Japan

Summary:

Purpose: biological dose indication of employees of the Ministry of Emergency Situations of Russia who took part in the work in Japan in connection with the accident at Fukushima-1 NPP and several journalists covering this event. Material and methods. The analysis of chromosomal aberrations in peripheral blood lymphocyte cultures of 46 people was performed. Results. The frequency of chromosomal damages exceeded background levels in only 3 people, and aberration character testified irradiation in previous situations. Conclusion. The significant overexposure of these workers during they stayed in Japan is absent, however it is necessary to perform a preliminary analysis of chromosome aberrations if you intend to exercise of biological dose indication after returning of people from areas of potential exposure.

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2014_04-01_796-800.pdf356.55 KB