Saratov JOURNAL of Medical and Scientific Research

radiopharmaceutical

Qualitative and quantitative comparisons of bone PET-imaging using 68Ga-oxabiphor and Na18F

Year: 2017, volume 13 Issue: №4 Pages: 886-891
Heading: radiation medicine Article type: Original article
Authors: Lunyov A.S., Clement'eva О.Е., Lunyova К.А., Zhukova M.V., Malysheva А.О.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

The aim of the study is to compare qualitative and quantitative characteristics of the experimental mice bone pathology using of Na18F and prospective radiotracer"Oxabigal, 68Ga" (complex of gallium-68 with oxa-bys-ethylenenitrile tetra (methylene phosphonic acid). Material and Methods. 30 nonlinear mice-female with the model of bone pathology were used in the experiment. Na18F and "Oxabigal, 68Ga" were injected to animals (i.v). Then mice were scanned using PET-imaging with subsequent calculation of pharmacokinetics parameters. Results. The intravenous injection of two radiotracers enabled to visualize of simulated bone pathology using PET. Conclusion. The experimental pathological foci were able to visualize within the first hour after i.v using of the "Oxabigal, 68Ga" and Na18F. There is a statistically significant difference between blood accumulation of radiopharmaceuticals labeled different radionuclides. However the difference doesn't matter for positive results we have got. 68Ga-labeled bone-seeking radiopharmaceuticals and its generator producing method are important supplement for independent choice of using different radiotracers for PET-imaging (such as Na18F) of bone pathology.

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Experimental assessment of the application possibility of radiopharmaceutical 68Ga-citrate for Pet-imaging of inflammation

Summary:

The aim of the study is to compare of 67Ga- and 68Ga-citrate pharmacokinetics and prove their similarity. Prior i. v. injection of physiologically acceptable compound of Fe-citrate (III) increases blood clearance and accumulation in inflammation. Materials and methods. 110 nonlinear rats-female with model of soft tissue inflammation were used in experiment. Animals i. v. were injected 67Ga- and 68Ga-citrate with premedication of Fe-citrate (III) and without it. Results. Prior injection of Fe-citrate (III) increases blood clearance, accumulation in inflammation (for 1 h past injection) and intensive excretion of radiopharmaceutical. Conclusion. There is no statistically significant difference between biodistri-bution of radiopharmaceutical labeled different gallium isotopes. It's positive and promising for application possibility of 68Ga-citrate for PET-imaging of inflammation early (for 1 h past injection).

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