Saratov JOURNAL of Medical and Scientific Research

lipid peroxidation

Lipids in the structure and functions of biological membranes

Year: 2014, volume 10 Issue: №2 Pages: 262-266
Heading: Physiology and Pathophysiology Article type: Review
Authors: Kuznetsov V.I., Morrison V.V., Lisko О.В., Tsareva T.D., Sretenskaya D.A., Gavrilova I.В., Hlebozharova O.A.
Organization: Saratov State Medical University
Summary:

Lipids are one of the main components of cellular membranes. Lipids make up 30-55% of the cell content depending on the types of cells. Phospholipids, sphingomyelins, cholesterol, etc. are characteristic to cellular membranes. The composition of lipids of the both sides of the membranes differs. This fact determines asymmetry of the structure of bili-pid layer. The reason for many pathologies is the changes in the properties of cellular membranes with the modification of their components. The study of structure and functioning of cellular biomembranes is essential for many researchers. The condition of membranes, their quality, their quantitative composition and modification under the influence of different factors as well as their interaction with carbohydrate and protein component are of great importance for the functioning of both membranes, cells and the body in general. Analysis and structuring of lipids and their functions in biological membranes are studied.

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Activity of processes of a lipoperoksidation at patients with a long postoperative pain syndrome against the combined application of application of low-intensive infrared laser therapy at impact on thymus area and pantovegin electrophoresis

Summary:

The aim of the study was to optimize the treatment of postoperative gynecological patients using physiotherapy method. Material and methods. It was examined 220 patients in postoperative period. It was investigated antioxidant status and lipid peroxidation. Results. It is demonstrated that patients with prolonged postoperative pain disorders are more pronounced as compared with the control group. The article presents data on the effectiveness of the impact on the antioxidant system and lipid peroxidation in postoperative period of combined use of low-intensity infrared laser therapy when exposed area of the thymus and in pantovegin electrophoresis in patients sustained postoperative pain after gynecological laparotomy. Conclusion. It is shown that this method helps to reduce pain in the postoperative wound.

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Molecular and cellular mechanisms of destabilization of membranes and prenatal discharge of amniotic fluid

Year: 2013, volume 9 Issue: №4 Pages: 644-648
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Mikhaylov А.V., Dyatlova L.I., Chesnokova N.P., Ponukalina Е.V., Glukhova T.N.
Organization: Perinatal Centre, Saratov , Saratov State Medical University
Summary:

Purpose: to establish the role of activation of lipid peroxidation and antioxidant deficiency of blood and amniotic fluid in the destabilization of membranes with early prenatal discharge of amniotic fluid. Material and methods. The analysis of lipid peroxidation products content in blood and amniotic fluid — diene conjugates (DC), malondialdehyde (MDA) and the quantitative determination of total peroxides (OxyStat), the estimation of the total antioxidant status (TAS), the activity of SOD and the content of ceruloplasmin in 20 pregnant with premature rupture of membranes in the gestation period of 22-34 weeks, were hospitalized at the Department of Pathology of Pregnancy of Saratov Perinatal Center in 2012. DC and MDA determination was carried out by conventional spectrophotometric methods of research, quantitative determination of peroxides (OxyStat) was carried out by enzyme immunoassay analyzer «Alfa Prime» («Meredith Diagnostics», 2008 using chemicals made by the company «Bender Medsystems»). The study of antioxidant status of serum and amniotic fluid was performed by enzyme immunoassay analyzer «Alfa Prime» («Meredith Diagnostics», England, 2008). Reagents («Bender Medsystems», Austria) were used to determine the total antioxidant status (TAS) and the SOD activity. To assess the content of ceruloplasmin reagent «Sentinel» (Italy) was used. Results. Indicators of lipid peroxidation in blood and amniotic fluid and anti-radical protection of biological membranes of cells and body fluids in the "mother-placenta-fetus" increased. Conclusion. Systemic activation of lipid peroxidation has been proved to be a
pathogenetic factor in the failure of membranes in prenatal discharge of amniotic fluid. The increase in the blood levels of lipid peroxidation products on the background of the activation of antioxidant system is considered as a prognostic sign of abortion.

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Pathogenetic interrelation of disturbances in metabolic status, cell composition and rheological properties of blood in surface thermal injuries, their diagnostic and prognostic significance

Year: 2011, volume 7 Issue: №4 Pages: 795-800
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Polutova N.V., Chesnokova N.P., Ostrovsky N.V., Newazhai Т.A.
Organization: Saratov State Medical University
Summary:

Aim. To study the interrelation between the nature of system metabolic disturbances, rheological properties and cell composition of peripheral blood and the dynamics of the development of alterative and necrotic, regenerative and proliferative processes in a zone of surface thermal injury of the skin. Materials and methods. Complex clinical and laboratory examination of 30 patients suffering from surface burns (first-, second-, and third A degrees) was conducted. Results and conclusion: The examination allowed determining the interrelation of the severity of local destructive changes in a thermal injury zone and the nature of system metabolic disturbances typical for the system inflammatory response syndrome with the degree of lipid peroxidation process activation, insufficient activity of antioxidant blood system, increase in blood viscosity properties and cell composition

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Coorection Of Lipid Peroxydation And Antioxydant Protective System By Mexidol And Glycine In Patients With Acute Ethanol Intoxication

Year: 2009, volume 5 Issue: №4 Pages: 507-510
Heading: Clinical Pharmacology Article type: Original article
Authors: A.I. Savlukov, R. N. Kildebekova, R.S. Farshatov
Organization: Ministry of Defense of the RF, Bashkir Military Hospital, Bashkir State Medical University of the Russian Health Care
Summary:

The research goal is to study lipid peroxydation and ferments of antioxidant protection in group of patients with an acute alcohol intoxication and their correction by medicaments with antioxidant activity (mexidol, glycine and their combination). Patients with diagnosis of ethanol toxic action of moderate severity degree were under study. There were 4 groups - receiving standard therapy, standard therapy and glycine, standard therapy and mexidol, patients receiving standard therapy with combination of mexidol and glycine. Clinical condition and changes in system "lipid peroxidation - antioxidant protection» were estimated. The expressed improvement was revealed applying standard therapy with combination of mexidol and glycine

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ANESTHESIA FOR UROLOGICAL AND GYNECOLOGICAL OPERATIONS

Year: 2008, volume 4 Issue: №4 Pages: 35-37
Heading: Anaesthesiology and Reanimatology Article type: Original article
Authors: I.G. Zhdanov, S.A. Matveev
Organization: Saratov State Medical University
Summary:

The studies of free radical blood activity in surgical patients of urological and gynecological profile, operated under regional anesthesia (RA) or total intravenous anesthesia (TIVA) have demonstrated that biochemical blood parameters, characteristics of stress reaction during anesthesia and early postoperative period, underwent less marked changes and normalized quicker during regional anesthesia. Early postoperative period in regional anesthesia coursed better than in TIVA.

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FEATURES OF LIPID PEROXIDATION AND NEUROTROPHIC REGULATION IN PATIENTS SUFFERING FROM PARANOID SCHIZOPHRENIA

Year: 2008, volume 4 Issue: №3 Pages: 81-83
Heading: Psychiatry Article type: Original article
Authors: E.V. Kolesnichenko, V.B. Vilyanov
Organization: Saratov State Medical University
Summary:

The article deals with the features of lipid peroxidation, activity of the antioxidative systems and level of brain-derived neurotrophic factor in patients with paranoid schizophrenia. Present study indicates associations between the studied parameters and type of progression, duration of disease and gender of patients.

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