Saratov JOURNAL of Medical and Scientific Research

breast cancer

Diagnostic value of bio-markers in the prognosis of postoperative relapses and metastases in patients with breast cancer

Year: 2017, volume 13 Issue: №2 Pages: 239-244
Heading: Oncology Article type: Original article
Authors: Cheburkayeva M.Yu., Zakharova N.B., Fedorov V.E., Teryoshkina N.E., Gergenreter Yu.S.
Organization: Regional Oncology center №2, Saratov State Medical University
Summary:

Purpose: to improve the diagnosis of relapse and metastasis of breast cancer in the postoperative period. Material and methods. 123 women were examined. Of these, 30 practically healthy women made up a control group, 20 women had benign breast diseases, 73 had breast cancer. The patients with ВС before the surgical intervention were divided into groups according to the stage of the disease. The 1st group consisted of 30 practically healthy women. In the second group — 20 women with fibroadenomas of the breast. In the third group — 33 women with l-ll stages of breast cancer without regional metastases. The 4th group consisted of 22 women with stage II breast cancer with regional metastases, in the 5th group — 18 patients with stage III breast cancer. After surgery, 68 patients were re-examined and divided into 2 analytical groups. The 6th group included women without clinical manifestations of relapses and metastases in the postoperative period — 44 (64.7%). Group 7 consisted of 24 (35.3%) women who had metastasis and local recurrences of the disease in the postoperative period. To determine the content of fetal proteins (Ca-15-3, Ca-125, REA), IL-8 and VEGF, commercial sets of reagents for solid-phase enzyme-linked immunosorbent assays were used. Results. Analysis of the data obtained showed that the most significant increase in serum and plasma VEGF levels occurred in breast cancer patients with clinical signs of metastasis and recurrence of the disease. Of fetal proteins, a significant increase in blood content showed Ca15-3 and CEA. Conclusion. We can assume that in patients with breast cancer only in the postoperative period, the rise in VEGF was associated with the growth of tumor tissue and the development of invasion and metastasis.

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Role of functional activity abnormalities of hypothalamic-pituitary-gonadal system in pathogenesis of neoplastic proliferation in patients with breast cancer

Year: 2012, volume 8 Issue: №4 Pages: 915-919
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Chesnokova N.P., Barsukov V.Yu., Zlobnova О.A.
Organization: Saratov State Medical University
Summary:

The research goal is to determine the pathogenic relationship between the dynamic changes of content of individual fractions of estrogen, progesterone, follicle-stimulating hormone, luteinizing hormone and somatotropic hormone in blood of patients with breast cancer from the stage of neoplasia spread. Methods: The authors have performed comparative evaluation of functional state of hypothalamic — pituitary — gonadal system in 128 patients with infiltrating ductal breast carcinoma (clinically nodular pathology form) using enzyme-linked immunosorbent analysis. Results: Examination of hormone profile of peripheral blood of patients with nodular breast cancer has revealed presence of centrogenous hormone influence on peripheral glands supplied by hormones of hypothalamic — pituitary system such as follicle-stimulating hormone and luteinizing hormone, these patients being of reproductive, climacteric and post-menopausal ages. At the same time, progress of initial stages of neoplastic proliferation in patients with breast cancer has been naturally accompanied by increase of estradiol level in blood, decrease of progesterone and estriol levels in blood. These levels have been parallel to the stage of neoplastic process. Hormone disbalance has been also characterized by increase of somatotropic hormone level in blood of patients with breast cancer. Hormone level increasing has been progressed by metastasizing neoplastic cells. Conclusion: The leading role in the pathogenesis of breast cancer in patients of different age groups should be assigned to the development of hormone disbalance. It should be noted that the principle of «feedback» between the central hormone influences and blood levels of hormones of peripheral glands has not been determined.

Keywords: breast cancer
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Mammary glands diseases in adolescent girls (review)

Year: 2011, volume 7 Issue: №2 Pages: 465-470
Heading: Pediatrics Article type: Review
Authors: Gumenyuk O.I., Chernenkov Yu.V.
Organization: Saratov State Medical University
Summary:

The research work provides current data about prevalence of dysmorphia and mammary glands diseases in adolescent girls

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PECULIARITIES OF MORPHOLOGICAL VERIFICATION IN BREAST CANCER

Year: 2008, volume 4 Issue: №2 Pages: 44-47
Heading: Macro- and Micromorphology Article type: Original article
Authors: S.S. Afanasieva, T.N.Popova, L.F. Zhandarova
Organization: Saratov State Medical University
Summary:

80 case histories of patients with breast cancer were analyzed. During the preoperative examination with objective and instrumental examination methods used the malignant process was suspected but no morphological verification was received. Physical examination revealed 75% cases of cancer. Roentgenologic evidence of malignant tumor was found in 43.5% women. Ultrasound examination of mammary glands showed that 57.7% of patients had cancer symptoms. Despite the repeated puncture aspiration biopsy, preoperative morphological examination proved to be negative. The reasons of morphological verification failure are connected with technical difficulties and morphological features of tumor structure. Negative malignant process verification necessitated the diagnostic partial mastectomy. To achieve ablasticity ofexcisional biopsyit is necessary to keep 2 cm from the tumor. Staged morphological diagnosis verifies the diagnosis in all patients, allowing to choose the adequate extentof surgical procedures.

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