Saratov JOURNAL of Medical and Scientific Research

Central Scientific Research Experimental Institute 33

Exotoxin A Pseudomonas aeruginosa influence on working efficiency of white rats

Year: 2017, volume 13 Issue: №3 Pages: 472-474
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Morrison V.V., Popovich V.I., Vasyutina V.O., Morrison A.V.
Organization: Central Scientific Research Experimental Institute 33, Saratov State Medical University
Summary:

Objective: to study exotoxin A Pseudomonas aeruginosa influence on physical and mental efficiency of white rats. Material and Methods. The experiments were carried out on white rats following intraperitoneal injections of exotoxin A Pseudomonas of different doses (0.1,0.5 and 1.0 LD50). Physical and mental efficiency of white rats was determined by the scheme of "Machfs camera". Results. Introducing exotoxin A Pseudomonas of 1 LD50 there was conditioned response damage in 20% of animals. The amount of cases of physical incapacity introducing highly effective doses of exotoxin A Pseudomonas overcomes the amount of cases of reaction destruction (44%). Conclusion. Exotoxin A Pseudomonas aeruginosa does not reveal a selective effect on the central nervous system and significant influence on physical efficiency of white rats.

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Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity in dynamics: an animal model in white mice

Year: 2015, volume 11 Issue: №4 Pages: 526-529
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Morrison A.V., Popovich V.I., Morrison V.V.
Organization: Central Scientific Research Experimental Institute 33, Saratov State Medical University
Summary:

Purpose: to study biochemical indices of peripheral blood which show organs functional changes. Material and Methods. The experiments were carried out on white mice in dynamics development of pseudomonas aeruginosa caused by intraperitoneal injection of various dosage of exotoxin A. Results. The dosage-dependent disturbances in activity of transaminases, a-HBDH, in content of proteins, lipids and cholesterol were revealed. The received data have determined the hepatotoxic effect of pseudomonas aeruginosa exotoxin A on changes of biochemical blood markers of liver function. Conclusion. The expressed hepatotoxic effect of Pseudomonas aeruginosa exotoxin A has been determined during all the phases of experiment even at sublethal toxin dose.

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Pseudomonas infection: exotoxin A effect

Year: 2014, volume 10 Issue: №3 Pages: 542-546
Heading: Skin Diseases Article type: Review
Authors: Morrison A.V., Popovich V.I., Morrison V.V..
Organization: Central Scientific Research Experimental Institute 33, Saratov State Medical University
Summary:

The aim of the article is to present the data analysis of the Russian and foreign literature concerning the current situation of the problem, the frequency and mechanisms of pseudomonas infection development and factors of patho-genicity of Pseudomonas aeruginosa. The mechanisms of exotoxin A effect have been under the study

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