Saratov JOURNAL of Medical and Scientific Research

Proceedings of all-Russia week of science with international participants

Proceeding of all-Rassia week of science with international participants

Year: 2016, volume 12 Issue: №2 Pages: 220-235
Heading: Proceedings of all-Russia week of science with international participants Article type: Tesis
Authors: Астраханцева Ю.С., Красникова Н.В., Напалкова М.В., Кофтина В.А., Русецкая Н.Ю., Дедова Т.А., Усова С.В., Пугнер А.С., Шерстнева В.Н., Ивличева А.В., Чувашова М.С., Ляпина Е.П., Лиско О.Б., Царева Т.Д., Зернова К.Г., Шашков К.Г., Гурьянов А.М., Караваев Н.В., Чехонацкий И.А., Чехонацкий В.А., Чехонацкая М.Л., Васютина В.О., Моррисон В.В., Долич В.Н., Урядова Л.П., Малюгин Д.С., Хворостухина А.И., Поспелов М.В., Ивахина С.А., Райкова К.А., Савенкова Е.Н., Амрахова Э.А., Ромакина Н.А., Вязовченко В.А., Гостюнина Л.С., Горина Н.А., Новокрещенова И.Г., Викторова Е.А., Понукалин А.Н., Андреева А.А., Гевелера Н.И., Шаркова Е.А., Полуконова А.В., Прилепский А.Ю., Полуконова Н.В., Соколов А.В., Рыкалина Е.Б., Решетько О.В., Ващенко И.С., Фахрудинова Э.Р., Златорев А.М., Казимирова Н.Е., Рыбкова М.А., Шашина М.М., Мыльников А.М., Удалов Е.А., Моржина В.А., Мудрак Д.А., Наволокин Н.А., Берегамян Л.А., Доровская А.И., Студеникин Л.В., Бондаревский И.Я., Ланкина Л.Ш., Хворостухина Н.Ф., Крючков И.А., Емельянова Н.В., Россоловский А.Н., Джалавян Я.В., Семочкина Л.В., Каменских Т.Г., Андрейченко О.А., Колбенев И.О., Назаренко К.А., Кузнецова Е.С., Филина Н.Ю., Махина В.И., Волошинова Е.В., Скрипцова С.А., Твердохлеб С.А., Фомин Ю.Р., Фирсова И.В., Давыдова Н.В., Киреев В.С., Погорелова Ю.С., Козлова А.Е., Сизов С.В., Абросимова Ю.С., Деревянкина А.В., Суетенков Д.Е., Тычина С.А., Корчаков Н.В., Маслякова Г.Н., Ленина Д.А., Веретельникова Ю.Я.
Organization: Saratov State Medical University
Summary:

Она содержит исходя из всех-Rassia недели науки с международными участниками.

Keywords: -
AttachmentSize
2016_02_220-235.pdf469.14 KB

Integrative approach to pre-operative determination of clinically significant prostate cancer

Year: 2015, volume 11 Issue: №3 Pages: 345-348
Heading: Proceedings of all-Russia week of science with international participants Article type: Original article
Authors: Shatylko T.V., Popkov V.M., Fomkin R.N.
Organization: Saratov State Medical University
Summary:

Aim: improvement of early diagnostics of prostate cancer by developing a technique, which makes possible to predict its clinical significance in outpatient setting before initiation of invasive procedures. Material and Methods. Clinical data of 398 patients who underwent transrectal prostate biopsy in 2012-2014 in SSMU S. R. Mirotvortsev Clinical Hospital, was used to build an artificial neural network, while its output allowed to determine whether the tumour corresponds to Epstein criteria and which D'Amico risk group it belongs to. Internal validation was performed on 80 patients, who underwent prostate biopsy in September 2014 — December 2014. Sensitivity, specificity, positive and negative predictive value of artificial neural network were calculated. Results. Accuracy of predicting adenocarcinoma presence in biopsy specimen was 93,75%; accuracy of predicting whether the cancer meets active surveillance criteria was 90%. Accuracy of predicting T stage (T1c, T2a, T2b, T2c)was 57,1%. Prediction of D'Amico risk group was accurate in 70% of cases; for low-risk cancer accuracy was 81,2%. Conclusion. Artificial neural networks may be responsible for prostate cancer risk stratification and determination of its clinical significance prior to biopsy.

AttachmentSize
2015_03_345-348.pdf302.33 KB

Clermont operation as a preventive method of post-cholecystectomy complications

Year: 2015, volume 11 Issue: №3 Pages: 341-345
Heading: Proceedings of all-Russia week of science with international participants Article type: Original article
Authors: Studenikin L.V., Bondarevsky I.Ya.
Organization: South Ural State Medical University
Summary:

Objective: to contribute to better surgical intervention outcomes in patients with cholelithiasis. Material and Methods. 41 patients were investigated prior to elective cholecystectomy The group of the study has formed the patients with raised level of the total bile acids and verified X-rays duodenal dyskinesia in subcompensation. These patients underwent laparoscopic cholecystectomy supplemented with mobilization of duodenojejunal junction without dissection of Treitz ligament (Clermont operation). Other patients underwent standard laparoscopic cholecystectomy. Life quality evaluation was performed 30 days after the surgical intervention using the unified GSRS questionnaire followed by statistical treatment. Results. Laparoscopic cholecystectomy performed simultaneously with Clermont procedure is executed in 29,3% cases (12 patients) with duodenal dyskinesia according to the classification of Ya. D. Vitebsky Life quality in group of the study was well above, than in groups of the comparison. The bile acids in group of the study were far less, than in comparison groups. Conclusion. Laparoscopic cholecystectomy performed simultaneously with Clermont operation is considered to be minimally invasive and rather effective in prevention of post-cholecystectomy complications.

AttachmentSize
2015_03_341-345.pdf986.49 KB

Analysis of efficacy of travoprost with a preservative polyquad in the treatment of patients with primary open-angle glaucoma

Year: 2015, volume 11 Issue: №3 Pages: 337-341
Heading: Proceedings of all-Russia week of science with international participants Article type: Original article
Authors: Petrova Yu.V., Veselova E.V.
Organization: Saratov State Medical University
Summary:

The purpose was to evaluate the efficacy and tolerability of travoprost and timolol use in the treatment of patients with initial stage of primary open angle glaucoma (POAG), as well as a preservative effect on the state of the cornea. Material and Methods. We observed 30 patients with a diagnosis of POAG first revealed. Group 1 patients (24 eyes) afforded 0.004% solution travoprost, patients in Group 2 (16 eyes) — 0.5% solution of timolol maleate. Patients in Group 1 who received travoprost with ВАК were administered travoprost with preservative polyquad in the same mode instillation. After 3 months after changing medication patients underwent examination of the cornea by laser scanning confocal imaging. Results. Intraocular pressure (IOP) in patients in Group 1 dropped from 33±3mm Hg. Article 18±2mm Hg.Art. In group 2, IOP decreased from 32±2mm Hg. to 21 ±1,5 mm Hg. Art. After 3 months of treatment with travoprost polyquad total number of epithelial cells of the cornea increased to 6231 ±415 cells/ mm2, signs of edema were not detected in 18 of 24 eyes in 6 cases, swelling of the corneal epithelium decreased, decreased number of "bright" keratocytes, endothelial cells well visualized and of hexagonal shape. Conclusion. Application of travoprost in patients with POAG provides a marked hypotensive effect compared with timolol. Application of travoprost with polyquad improves the state of the front layers of the epithelium and the corneal stroma of patients with glaucoma, reduced patients complaints to sensation of a foreign body and eye discomfort and redness.

AttachmentSize
2015_03_337-341.pdf1.69 MB

Expert quality evaluation of out-patient medical care for patients with cerebral infarction in the early recovery period

Year: 2015, volume 11 Issue: №3 Pages: 333-337
Heading: Proceedings of all-Russia week of science with international participants Article type: Original article
Authors: Parkhomenko А.А., Erugina M.V., Kolokolov O.V.
Organization: Saratov State Medical University
Summary:

The purpose of the research is to work out the measures of an improvement of the out-patient rehabilitation of patients with cerebral infarction in the early recovery period. Materials and Methods. Method of the expert evaluation was used for collecting data (29 questionnaires); analysis of variance, Kolmogorov-Smirnovtest, Kendall coefficient of concordance, Kemeni median were applied for processing data. Results. According to the expert opinion it is necessary to increase the role of polyclinics in a process of the rehabilitation of patients with cerebral infarction and to improve the quality of out-patient medical care in cases of this disease. Experts consider that insufficient technical provision and lack of personnel in the system of primary health care foremost lower quality of medical care. Absence of an equipment and staff shortage lead to imperfection of the rehabilitation process and poor results of recovery after cerebral infarction. Conclusion. The improvement of out-patient medical care in the early recovery period of cerebral infarction is possible through the integral impact on all components of the quality: structure (upgrade of equipment and staff provision), process (increase of length and frequency of patients' visits) and result (adoption of efficiency criteria of cerebral infarction treatment).

AttachmentSize
2015_03_333-337.pdf377.04 KB

Изменения лейкоцитарной формулы, красного костного мозга и опухоли лабораторных крыс с перевитой саркомой-45 при введении экстрактов аврана лекарственного, бессмертника песчаного, кукурузы антациановой

Year: 2015, volume 11 Issue: №3 Pages: 328-332
Heading: Proceedings of all-Russia week of science with international participants Article type: Original article
Authors: Наволокин Н.А., Мудрак Д.А., Тычина С.А., Корчаков Н.В.
Organization: Saratov State Medical University
Summary:

Цель; изучить влияние флавоноидсодержащих экстрактов аврана лекарственного, бессмертника песчаного и кукурузы обыкновенной на костный мозг и периферическую кровь при внутримышечном и пероральном введениях в эксперименте на лабораторных крысах с перевитой саркомой-45. Материал и методы. В эксперименте использовано 48 самцов белых беспородных крыс линии Wistar, которым через 72 часа после перевивки опухоли перорально и внутримышечно в течение двух недель ежедневно вводили экстракты (аврана, бессмертника и кукурузы). При этом ежедневно оценивали динамику роста опухоли. После окончания эксперимента у животных забирали кровь, костный мозг (изготавливали мазки) и опухоль для гистологического исследования. В дальнейшем подсчитывали клетки и рассчитывали лейкоцитарную формулу и миелограмму, проводили описание гистологических препаратов опухоли. Результаты. Все три изученных экстракта замедляют темпы роста перевиваемой саркомы и вызывают в ней выраженные морфологические изменения, а также не оказывают токсического эффекта на периферическую кровь. Экстракты аврана лекарственного и кукурузы антациаоновой благоприятно влияют и нормализуют процентное соотношение клеток красного костного мозга у животных с перевитой саркомой, а экстракт бессмертника не оказывает влияния на миелограмму. Заключение. Флавоноид-содержащие экстракты положительное влияют на периферическую кровь и костный мозг и обладают противоопухолевой активностью.

AttachmentSize
2015_03_328-332.pdf335.5 KB

Results of longterm follow-up of children with low birth weight

Year: 2014, volume 10 Issue: №4 Pages: 691-693
Heading: Proceedings of all-Russia week of science with international participants Article type: Original article
Authors: Panina O.S., Chemenkov Yu.V., Lavrova D.B., Belyaeva N.A.
Organization: Saratov State Medical University
Summary:

The purpose of our research is a long-term follow up study of children with low birth weight. Materials and methods. 115 premature children from 0 to 7 years old took part in the research process. The children gestational age was 30-35 weeks and their birth weight was less than 2500 g. All children had thorough clinical and laboratory, instrumental and psychological examination up to the age of seven. Their parents took part in questionnaire survey. Results. Development of all aspects of mentality is retarded and such retardation can be observed in the first months of life as slow learning of new things and peculiarities of psychological interrelations with the world around in the form of negative response to the influence of sensory stimuli, behavioral disorders and difficulties in social adaptation. Conclusion. Children with low birth weight are included into the high-risk group of disabling abnormalities and persistent non-disabling disorders. These children need early comprehensive rehabilitation and, at the same time, extremely careful prognosis of their further development.

AttachmentSize
2014_04_691-693.pdf253.28 KB

Retinopathies in premature infants, incidence, risk factors, prevention and treatment

Year: 2014, volume 10 Issue: №4 Pages: 688-691
Heading: Proceedings of all-Russia week of science with international participants Article type: Original article
Authors: Chernenkov Yu.V., Nechaev V.N., Tereshenko V.A., Rodionova O.A.
Organization: Saratov State Medical University, Saratov Perinatal Centre
Summary:

Research Objective: Analysis of incidence and accompanying states, detection of risk factors of retinopathies in premature infants (RN), dynamic monitoring and improvement of medical actions. Material and Methods: 134 children have been surveyed in the group of risk on development of RN for the last 2 years. Results: From 134 surveyed infants with gestation from 22 to 37 weeks and body weight at birth from 750 to 2500 kg. At 56 children (41,8%) the retinopathy of various degree of expressiveness has been revealed. 38 children with RN of 1-2 stages (67,8%) from which at 22 (39,3%) —the disease ended with the induced regress after a course of «retinalamin», at 16 (28,6% of RN) — spontaneous regress. 4 children (7,1%) had RN 2-3 of the Art., 3-4 Art. at 12 (21,4%), and 5 Art. a cicatricial phase with retinal detachment — 2 (3,5%). In 12 cases the laser photocoagulation in the eye centers is carried out. Conclusion: The revealed relationship of cause and effect of risk factors of formation of RN with features of a current ofthe neonatal period at patients with RN, promoted development of the system of monitoring, implementation of the program of treatment and rehabilitation of prematurely born children suffering RN. Ophthalmologic screening of premature infants with the use of the ophthalmologic digital pediatric camera "Ret Cam 3" allows to diagnose a retinopathy at early stages, in due time to hold preventive an3 medical measures that allows to lower the invalidization of this group of children.

AttachmentSize
2014_04_688-691.pdf297.21 KB

Estimation of health indicators of children born by means of application of reproductive technologies

Year: 2014, volume 10 Issue: №4 Pages: 683-688
Heading: Proceedings of all-Russia week of science with international participants Article type: Original article
Authors: Chernenkov Yu.V., Nechaev V.N., Stasova Yu.V.
Organization: Saratov State Medical University
Summary:

Objective: To examine health of children born by means of ART according to Perinatal Center of Saratov region for the last 2 years. Material and Methods: 70 pregnant women and 96 newborns with the use of ART were under examination. The causes of premature birth by women with ART, high degree of disease incidence among newborns and mortinatality are considered (рассматриваются) in the article. Results: The important factors of amnionic membranes breaking are distinguished: maternal age, multifetation, genital and extragenital pathology, antenatal infections and fetation anomaly. Highly premature babies cause not only high neonatal disease rate and disability, but also are key element in procreational loses. Women with congelated embryo transfer less often experience premature birth, also disease rate and neurologic abnormalities are less frequent. Two and more embryo transfer more often leads to habitual miscarriage. Conclusion: Mothers-to-children health indicators after using ART demonstrate the necessity of prenatal diagnostics improvement and taking measures in monitoring such women and newborns. High quality preimplantation preparation plays a major role in fetus pathology reduction. Prescriptions and counter indications to this procedure should be thoroughly evaluated; no more than 1-2 ova should be transferred.

AttachmentSize
2014_04_683-688.pdf317.94 KB

The model of prophylactic conversation on health effects of smoking

Year: 2014, volume 10 Issue: №4 Pages: 681-683
Heading: Proceedings of all-Russia week of science with international participants Article type: Original article
Authors: Strode А.А., Prokofyeva L.P.
Organization: Saratov State Medical University
Summary:

The preventive activity, which aims to improve the health of the entire population, takes an important place in the medical profession. Counseling, physical examinations, prophylactic medical examinations and health service are considered as the main types of the preventive activities. Objective; to study the situation about smoking in Russia and Latvia, to develop methods of prevention in the different target audiences. Material and Methods. The authors used the original questionnaire containing eight questions that allowed them to clarify the attitude of the respondents concerning the problem of smoking. Results. Sociological research (50 respondents from different cities of Russia and Latvia, 52% of men 48% of women, different age groups from 16 to 58 years) showed the urgent need for ongoing preventive work among the nicotine active population. Conclusion. The analysis of data led to the conclusion on the addition of female smokers, lowering of the "first cigarette" age and the increase smoker index. The study has been carried out to develop a model of conversation about the dangers of smoking, taking into account the target audience.

AttachmentSize
2014_04_681-683.pdf492.05 KB