Saratov JOURNAL of Medical and Scientific Research

age-related macular degeneration

Role of melatonin in pathogenesis of age-related macular degeneration

Year: 2019, volume 15 Issue: №2 Pages: 559-563
Heading: Ophtalmology Article type: Review
Authors: Khodzhaev N.S., Chuprov A.D., Kim S.M.
Organization: The S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in people aged 50 years and older in the advanced world. The article deals with the epidemiology and pathogenesis of the disease. Special attention is given to a new approach to the prevention and treatment of AMD with the help of melatonin; modern management options and scientifc achievements are discussed. Many researchers have shown that melatonin is able to protect retinal epithelial cells from oxidative damage. Perhaps the physiological reduction of melatonin in the elderly may be an important factor in the dysfunction of the retinal pigment epithelium, which is the cause of AMD.

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Informativeness of optical coherence tomography in differential diagnosis of central chorioretinitis and age-related macular degeneration

Year: 2019, volume 15 Issue: №2 Pages: 524-528
Heading: Ophtalmology Article type: Original article
Authors: Popova L.I., Kudryavtseva Yu.V., Demakova L.V., Obsekova K.S.
Organization: Kirov State Medical University
Summary:

Purpose: the analysis of the informativeness of optical coherence tomography as an additional method in the diferential diagnosis of central chorioretinitis and age-related macular degeneration. Material and Methods. Studies conducted in 44 patients. The frst group included 20 patients with central chorioretinitis. The second group consisted of 24 patients with diferent forms of age-related macular degeneration. The informativeness of optical coherence tomography was analyzed in the diferential diagnosis of central chorioretinitis and AMD. Results. Uncomplicated forms of AMD and central chorioretinitis have a diferent tomographic picture. Using the OCT method it is possible to judge the change in the thickness of the choroid which increases in the acute phase of chorioretinitis. In the atrophic form of AMD, the thinning of the choroid extends over a considerable distance. OCT provides additional information on the localization of the infammatory focus. Conclusion. OCT-diferences were found at the level of the pigment epithelium, retinal photoreceptors and choroid in infammatory processes and degenerative diseases, which can help in difcult cases of diferential diagnosis. However, secondary choroidal neovascularization does not have specifc OCT signs in various diseases, since it is a complication of the main process.

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Fluorescent angiography and optical coherence tomography with angiography of the ocular fundus in patients with "the wet" form of an age-related macular degeneration.

Year: 2017, volume 13 Issue: №2 Pages: 345-349
Heading: Ophtalmology Article type: Original article
Authors: Virsta A.M., Kamenskikh T.G., Nugaeva N.R., Kolbenev I.O., Gileva E/V.
Organization: Saratov State Medical University
Summary:

Purpose: to investigate the informative value of fluorescent angiography (FA) and optical coherence tomography with fundus angiography (angio-OCT) in the diagnosis of "wet" form of age-related macular degeneration (AMD). Material and methods. The present study included 20 patients (20 eyes) diagnosed with degeneration of macula and posterior pole of the eye, the "wet" form (late stage age-related macular degeneration, AREDS category 4). The study used machines: optical coherence tomography, Spectralis HRA+OCT (Heidelberg Engeneering, Germany), optical со- herence tomography-angiography CIRRUS HD-OCT MODEL 5000 (Carl Zeiss, Germany). Results. When conducting the FA, in 11 patients found the ill-defined zone of small leakage of dye in 7 patients revealed a clearly defined area of hyperfluorescence in the early phase, and marked leakage of dye in the late phase, 2 patients — uncertain indices. In connection with the received data questionable PHAGE in 11 patients, all were held angio-OCT, to clarify the localization of choroidal neovascularization (CNV). When performing angio-OCT in 11 patients revealed that "wet" form of AMD with occult choroidal neovascularization. In 7 patients there had been discovered classic CNV in 2 patients combined. Conclusion. Angio-OCT gives a clearer picture about the presence of a choroidal neovascular membrane that plays a significant role in determining the course of treatment of patients with wet age-related macular degeneration.

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Analysis of the results of multifocal electroretinogram and optical coherence tomography in diagnosis and monitoring of patients with age-related macular degeneration

Year: 2014, volume 10 Issue: №2 Pages: 308-313
Heading: Proceedings of all-Russia week of science with international participants Article type: Original article
Authors: Ait Ahmed Кh., Kamenskikh T.G.
Organization: Saratov State Medical University
Summary:

Purpose: to study the correlation between the results of the macular area responses by multifocal-electroretinog-raphy (mf-ERG) and the retina thickness obtained by the spectralis optical coherence tomography (ОСТ) in patients with age-related macular degeneration (AMD). Material and methods. 28 patients (32 eyes) where enrolled in the main group. The control group was up to 10 patients without any AMD's pathological sign in retina. All patients were examined by the optical coherence tomography (ОСТ) and multifocal electroretinography (mf-ERG). Results. The data showed a high level of negative correlation between the retinal thickness and electrical amplitudes of the fovea. With the group of "dry" AMD the rise of the macular thickness (drusen) not over 290 urn showed a moderate reduction of the amplitude on mf-ERG The group with "wet" AMD showed that a higher rise of the retinal thickness (edema, fibrosis) of the macular zone negatively influences the bio-electrical activity of this area and this fact was confirmed by a considerable decline of the amplitude on the mf-ERG. Conclusion. The AMD's pathological changes that have been observed by ОСТ are objectively confirmed by mf-ERG. The mf-ERG in supplement of ОСТ can be used as an important element in the complex studies and objectively monitoring of patients with AMD.

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