Saratov JOURNAL of Medical and Scientific Research

bone

The state of the hemocoagulation system and endothelial dysfunction in benign and malignant skeleton neoplasms

Year: 2018, volume 14 Issue: №3 Pages: 574-578
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Ponamarev I.R., Puchinyan D.M., Gladkova E.V., Korshunov G.V.
Organization:
Summary:

Aim: to study the functional status of the vascular endothelium and the activity of the hemocoagulation system, as well as the relationship between some indicators characterizing their state in patients with benign and malignant skeleton neoplasms. Material and Methods. 62 patients with benign (45) and malignant (17) bone neoplasms and 10 healthy individuals of the control group were examined. The coagulation properties of blood plasma and the content of vascular endothelial growth factor (VEGF), intercellular adhesion molecules of sICAM and adhesion molecules of vascular endothelium (sVCAM) in blood serum were investigated. Results. In patients with benign bone tumors, prothrombinase formation mechanisms were activated, the concentration of soluble fibrin-monomer complexes (FSC) was

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The role of skeletal tissue remodeling markers in the patho-genesis of implant-associated inflammation after primary knee arthroplasty

Year: 2018, volume 14 Issue: №3 Pages: 515-518
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Galashina Е.А., Bondarenko A.S., Ulyanov V.Yu., Klimov S.S.
Organization: Saratov State Medical University
Summary:

Aim: to reveal certain mechanisms of the pathogenesis of implant-associated inflammation by the level of resorption and bone tissue genesis markers in patients who underwent primary knee arthroplasty. Material and Methods. Main group consisted of 40 patients with implant-associated inflammation; first comparison group — of 20 patients with primary aseptic loosening of knee joint implant components; second comparison group — of 20 patients who underwent primary knee arthroplasty without complications in post-operative period; control group — of 20 conventionally healthy individuals. The levels of soluble receptor activator of nuclear factor kappa-B ligand and bone morphogenetic protein-2were defined in blood serum of all subjects by ELISA. Results. In patients of main group we observed more pronounced increase of soluble receptor activator of nuclear factor kappa-B ligand content and significant decrease of bone morphogenetic protein-2 content in blood serum; patients of first comparison group demonstrated activation of soluble receptor activator of nuclear factor kappa-B ligand and decreased levels of bone morphogenetic protein-2 in blood serum; patients of second comparison group did not demonstrate any changes in the studied indexes. Conclusion. The activation of soluble receptor activator of nuclear factor kappa-B ligand and decreased activity of bone morphogenetic protein-2 have leading role in the pathogenesis of implant-associated inflammation.

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Evaluation of the effectiveness of a resorbable membrane «Bio-Gidein» in combination with chitosan for the treatment of bone defects

Year: 2014, volume 10 Issue: №2 Pages: 239-245
Heading: Macro- and Micromorphology Article type: Original article
Authors: Kalmin O.V., Nikishin D.V., Volodina Yu.M.
Organization: Penza State University
Summary:

Objective: to evaluate the efficiency of a resorbable membrane «Bio-Gide» in combination with chitosan for guided bone regeneration during the degradation under the experimental conditions. Material and Methods. The histological methods provide the study of tissue samples from 6 adult rabbits from artificial mandible through 14, 28 and 42 days after surgery. In group 1 the treatment was carried out without the use of additional materials, by a blood clot. In group 2 closing of the damaged area was produced by xenopericardial plate «Bio-Gide» in combination with chitosan. Results. It has been established that the conduct of bone wound under a blood clot causes inflammatory response on the 14th day after the operation, to the 28th day inflammation disappears and it practically does not appear on the 42nd day. Closure of the bone defect using xenopericardial plate «Bio-Gide» with chitosan causes lesser inflammatory response. In the long-term period after the surgery inflammatory changes in the implantation can not be detected. Conclusion. Xenopericardial plate «Bio-Gide» in combination with chitosan has a positive impact on the recovery process of the bone defect. Neoplasm of bone occurs, the stage of development of cartilage is shortened. At the end of the experiment period xenopericardial plate is not detected indicating the high rate of its biodegradation.

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