Saratov JOURNAL of Medical and Scientific Research

interleukin-4

Correlation between the frequency of the infectious complications of abdominal surgery and the level of immune response to the surgical trauma

Year: 2013, volume 9 Issue: №4 Pages: 954-957
Heading: Surgery Article type: Original article
Authors: Korsakov I.N., Voskanyan S.E., Naydenov E.V., Timashkov D.A., Chervov A.Yu., Volkov A.A., Bolshakov M.S.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

Aim: to evaluate the correlations between the frequency of the infectious complications of abdominal surgery and the level of immune response to the surgery. Material and methods. The study has been conducted on 53 patients, who were undergone to pancreaticoduodenal resection with lymphadenectomy. Concentrations of interleukin-4 (IL-4) and interleukin-8 (IL-8) in blood serum were studied. Results. The concentrations of IL-8 were higher in patients with complications compared to those without complications. No statistically significant differences in the concentrations of IL-4 were revealed between the studied groups of patients. Conclusion. Concentrations of pro-and anti-inflammatory cytokines can be used to assess the risk of postoperative complications.

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