Saratov JOURNAL of Medical and Scientific Research

endothelial dysfunction

Cardiovascular risk factors and arterial stiffness in patients with ulcerative colitis

Year: 2019, volume 15 Issue: №3 Pages: 753-757
Heading: Cardiology Article type: Original article
Authors: Lipatova Т.Е., Mihailova Е.А., Dudaeva N.G.
Organization: Saratov State Medical University
Summary:

Purpose: to assess cardiovascular risk factors and arterial stiffness in patients with ulcerative colitis (UC) without clinical manifestations of cardiovascular diseases. Material and Methods. 76 patients with remission of UC, 40 patients with irritable bowel syndrome and 25 healthy volunteers of comparable age and gender were examined. The 10-year risk of fatal cardiovascular events (SCORE) was calculated. Daily monitoring of arterial stiffness, endothelium function together with its vasodilative, vasoconstrictive and adhesive functions were evaluated in all examinees. Results. Traditional cardiovascular risk factors such as hypercholesterolemia, obesity or hypertension were not typical for patients with UC. Risk SCORE was low in the majority of UC patients. Patients with UC were characterized by the increase of intima-media complex thickness, C-reactive protein level, and by the decrease of HDL cholesterol. UC patients demonstrated the increase of arterial rigidity and endothelial dysfunction which reflected in statistically significant decrease of endothelium-dependent vasodilation to 11.48%, and increase of plasma levels of endothelin-1, vascular adhesion molecules VCAM-1 and ICAM-1. Conclusion. UC patients need multidisciplinary approach to study their arterial rigidity and markers of endothelial dysfunction.

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The relation of carbohydrate metabolism disorders and markers of endothelial dysfunction in animals with absolute insulin defciency at biostimulation by autotransplantation of the skin fap

Year: 2019, volume 15 Issue: №2 Pages: 379-38
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Popykhova E.B., Ivanov A.N., Stepanova T.V., Pronina E.A., Lagutina D.D.
Organization: Saratov State Medical University
Summary:

The purpose of this work is to study the relationship of carbohydrate metabolism disorders and markers of endo-thelial dysfunction in animals with absolute insulin defciency at biostimulation by autotransplantation of the skin fap. Material and Methods. The study was conducted on 60 male white outbred rats, which were divided into: an intact control group, a two comparative and an experimental group. In animals of the comparison group, alloxan diabetes mellitus (DM) was caused, in rats from the experimental group, an autotransplantation of the skin fap was performed against the background of developed alloxan diabetes. The levels of glycated hemoglobin (HbA1c), glucose, C-reactive protein (CRP) and vascular endothelial growth factor (VEGF) were determined. Results. Autotransplantation of the skin fap causes a normalization of the glycemic profle in animals of the experimental group, and also reduces subclinical infammation caused by hyperglycemia and stabilizes the expression of VEGF.Diabetes causes an increase in HbA1c by 69 % and CRP by 11 %, while аutotransplantation of the skin fap leads to a decrease in the concentration of HbA1c by 28 % and CRP by 7 %. Conclusion. Autotransplantation of the skin fap reduces the risk of microcirculatory disorders due to hyperglycemia and chronic subclinical infammation.

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Systemic inflammatory response and cytokine profile at burn injury in dynamics

Year: 2017, volume 13 Issue: №2 Pages: 229-232
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Morrison V.V., Bozhedomov A.Yu., Simonyan M.A., Morrison A.V.
Organization: Leningrad Regional Clinical Hospital, Saratov State Medical University
Summary:

The aim of the article is to study the dynamics of indices of systemic inflammation in correlation with the following factors: the outcome of the disease, disturbances in proinflammatory cytokines rate and vascular endothelial dysfunction markers rate at burn injury in dynamics. Material and Methods. 152 patients with burn injuries over 30 units by Frank's index were under the study. The research on the level of interleukins, endothelial vessels growth factor, macrophage chemotactic protein, level of endothelin and C-reactive protein was performed with quantitative immuno-enzymatic detection. The amount of circulating of desquamated endothelial cells was accounted by phase-contrast microscopy. Results. Proinflammatory cytokines rate and vascular endothelial dysfunction markers rate significantly increase reaching their maximum indices to the 7-15th day of burn injury and indicating the expressiveness of systemic inflammatory response syndrome. Conclusion. The received data have become important in the determination of increased number of criteria of systemic inflammatory response syndrome depending on the outcomes of the burn injury and endothelial dysfunction development.

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Influence of low-intensity electromagnetic fields on endothelial function in patients with chronic heart failure

Year: 2014, volume 10 Issue: №1 Pages: 86-92
Heading: Сardiology Article type: Original article
Authors: Bokeria O.L., Kuular A.M.
Organization: Bakulev Center of Cardiovascular Surgery, Moscow State Medical Stomatological University n.a. A. I. Evdokimov
Summary:

Objective: to evaluate the influence of low-intensity electromagnetic fields on endogenous bioresonance therapy on the level of asymmetric dimethylarginine in blood, as well as on the parameters of microcirculation in the assessment of endothelial function in patients with chronic heart failure. Material and Methods. The basic group included 40 patients with chronic heart failure (NYHA II): 17 female and 23 male patients. The average age of the patients was 56,4±10 years. The control group consisted of healthy volunteers (20 patients, including 10 women, 10 men aged 31 ±5 years). Assessment of vasomotor state of the endothelium microcirculation was carried out with the help of laser Dopplerflow-metry on the apparatus LAKK-TEST (T) («Lazma», Russia). After the procedure endogenous bioresonance therapy was held. The intervention by low-intensity electromagnetic fields was carried out with the help of a hardware-software complex IMEDIS-EXPERT mode of endogenous bioresonance therapy for 15 minutes. Vasomotor endothelial function of microcirculation was evaluated. The concentration of an inhibitor of nitric oxide synthases, asymmetric dimethylar-ginine in blood before and after the exposure to the intervention by low-intensity electromagnetic fields was studied. Results. After the endogenous bioresonance therapy the microcirculation M parameter in the main group, on the background of iontophoresis with acetylcholine counted in average6,13±4,7 PF units. After iontophoresis with nitroprusside it was 5,9±3,8 PF units. In the control group the rate of myogenic oscillation amplitude (Am) amounted in average 0,75±0,13 Hz, in the main group it was 0,68±0,26 Hz. Reduction of myogenic tone in the control group was statistically significant (p

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Endothelial dysfunction in psoriasis and type 2 diabetes in terms of comorbidity

Year: 2013, volume 9 Issue: №3 Pages: 590-595
Heading: Dermatovenerology Article type: Review
Authors: Slesarenko N.A., Utz S.R., Shtoda U.M., Platonova A.N.
Organization: Saratov State Medical University
Summary:

In the article the analysis of medical literature of changing in a vascular endothelium in psoriasis and type 2 diabetes in a combination is given.

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Features of endothelial dysfunction changes at patients with systemic lupus erythematosus on a background of various therapy// Saratov Journal of Medical Scientific Research

Year: 2011, volume 7 Issue: №4 Pages: 822-827
Heading: Internal Diseases Article type: Original article
Authors: Nam I.F., Rebrov А.Р.
Organization: Saratov State Medical University, Saratov Regional Clinical Hospital
Summary:

Aim. To investigated endothelial dysfunction in patients with systemic lupus erythematosus (SLE), depending on different activity, duration of disease and different type of therapy. Methods. We examined 77 patients with SLE during 1 year. We administered puls therapy with high dose glucocorticoids and cyclophosphamide in the 33 patients. 44 patients were given low dose steroids orally or hydroxychloroquine. We investigated the number of circulating endothelial cells in peripheral blood. Vasoactive function was assessed in reactive hyperemia test, antitrombogenic function with short-lived ischemia was examined. Results. Patients with SLE demonstrated endothelial damage, its antitrombogenic and vasodilatation function was reduced especially in high activity of disease. Pulse therapy improved endothelial function after 12-month treatment periods. The activity of the SLE decreased what was associated with reduced endothelial damage. Also vasodilatation function improved, but anticoagulant activity was without changes. Conclusion. It is necessary to administer pulse therapy according to the right indication despite potential danger of steroids and cyclophosphamide on endothelial function. Probably pulse therapy should be used with vasoprotective drugs in order to improve anticoagulant function

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Endothelium Damage And Arterial Rigidity In Patients With Psoriatic Arthritis

Year: 2009, volume 5 Issue: №4 Pages: 544-548
Heading: Internal Diseases Article type: Original article
Authors: А.Р. Rebrov, I.Z. Gaydukova
Organization: Saratov State Medical University
Summary:

The research goal is to study the connection between activity of systemic inflammation, endothelium damage and arterial rigidity in patients with psoriatic arthritis (PsA). Expression of arterial damage (the level of circulation of endothe-liocytes (CEC)) and indices of arterial rigidity have been studied in 32 patients with PsA. Methods used in the investigation are oscillography, photopletismography and occlusion test. Control group consisted of 22 practically in good health state volunteers. Patients with PsA had endothelium dysfunction, damage of endothelium and higher arterial rigidity. These findings were related to PsA activity and observed in patients with serious joint damage

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Role Of Adhesion Molecules Vcam-1 And Ve-Cadherin In Endothelium Dysfunction Development At Hemorrhagic Fever With Renal Syndrome

Year: 2009, volume 5 Issue: №4 Pages: 478-481
Heading: Biochemistry Article type: Original article
Authors: А.А. Baygildina
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

The research goal is to determine the changes in concentration of both sVCAM-1 and VE-cadherin in blood serum of patients suffered from hemorrhagic fever with renal syndrome (HFRS). 87 patients aged 15-65 were examined. Concentrations of both sVCAM-1 and VE- cadherin in blood serum by means of "Bender MedSystems" (Austria) ELISA test were determined. It was shown that in both medium severe and severe forms of HFRS statistically the significant rise of sVCAM-1 concentration in blood with high indices in oliguric period took place. Complicated form was characterized by high indices of sVCAM-1 level in fever period, extremely decreasing in concentration in oliguric period and tendency to normalizing in clinical convalescence period. VE-cadherin level in blood was predominantly lower than control in all the observed groups with the exception of fever period in group with medium severe disease form. Negative correlation of normal intensity between adhesion molecules levels in blood was revealed. In conclusion it is necessary to point out that high VCAM-1 expression by endotheliocytes evidences the development of an adhesion form of endothelial dysfunction, low VE-cadherin production in a base for development of angiogenic form of endothelial dysfunction and changes in expression of these adhesion molecules that have adaptive metabolic response to macroorganism of HFRS pathogenic action

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ABOUT THE ROLE OF ENDOTHELIAL DYSFUNCTION IN GESTOSIS DEVELOPMENT

Year: 2007, volume 3 Issue: №3 Pages: 60-62
Heading: Obstetrics and Gynecology Article type: Original article
Authors: G.I. Khripunova, E.V. Ponukalina, G.S. Salakhieva
Organization: Saratov State Medical University
Summary:

The complex clinical and laboratory researches conducted in groups of the pregnant women with mild case of gestosis, middle serious preeclampsia and with heavys everity of gestosis. Anticoagulation and fibrinolytic activity of a wall of vessels on a background of creation of a short-lived ischemia were examined. Disturbance of a coagulative potential of a blood are actuated development endothelial dysfunction in groups of the pregnant women with middle serious preeclampsia and with heavy severity of gestosis.

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ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH DISTURBED MYOCARDIAL CONTRACTIVE ACTIVITY OF THE LEFT VENTRICLE IN CHRONIC HEART FAILURE PROGNOSIS

Year: 2008, volume 4 Issue: №2 Pages: 76-81
Heading: Internal Diseases Article type: Original article
Authors: N.A Kosheleva, A.P Rebrov
Organization: Saratov State Medical University
Summary:

The aim of the given study was to define antithrombogenic and vasodilative vascular wall activity in patients with disturbed function of left ventricle (LV), developed after Q-myocardial infarction; and to specify its role in chronic heart failure (CHF) prognosis. 40 patients after Q-myocardial infarction were examined; compare five group consisted of 20 patients. Antithrombogenic (anticoagulant and fibrinolytic) and vasomotor activity of vascular wall were determined. It was revealed that disturbance of systolic function of left ventricle in patients with CHF is accompanied by decrease of antithrombogenic and vasodilative vascular wall activity. Patients with IV functional class of CHF having long term CHF and blood release value consisted < 33%; during six months of monitoring the number of repeated unfavourable cardiovascular events was essentially increased.

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