Saratov JOURNAL of Medical and Scientific Research

Karpova O.V.

State Scientific Research Center n.a. A.I. Burnazyan — Federal Medical Biophysical Center of Federal Medical Biological Agency, Federal neurological center of extrapyramidal disorders and mental health, Neurologist.

Transarterial chemoembolization for primary and metastatic liver tumors

Year: 2016, volume 12 Issue: №4 Pages: 716-720
Heading: Oncology Article type: Review
Authors: Popov M.V., Aronov M.S., Voskanyan S.E., Karpova O.V.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

The literature review presents the methodology of transarterial chemoembolization (TACE) — widely used method of treatment of primary and secondary liver tumors. The TACE role as a neoadjuvant therapy and the role in the management of unresectable primary and secondary liver tumors are shown. The morphofunctional basis of TACE, benefits of superselective intra-arterial administration of cytostatic agents especially in combination with ischemic impact on a tumor are described. The subject of the choice of the chemotherapeutic agent is also touched; modern drug-loaded microspheres which allow the use of higher doses of the chemotherapeutic drug without increasing systemic effect and prolong its effect on tumor are described. Lack of correlation of presence and severity of a post-embolization syndrome with success of the procedure is noted.

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Role of a preoperative distal and proximal embolization of the right branch of the portal vein at surgical treatment of a liver malignant tumors

Year: 2016, volume 12 Issue: №4 Pages: 713-716
Heading: Oncology Article type: Original article
Authors: Popov M.V., Voskanyan S.E., Aronov M.S., Karpova O.V.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

Objective: assessment of safety and efficiency of application of the method of the distal and proximal embolization of the right branch of a portal vein using an occluder for preventive increase of the small future remaining liver amount in case of the planned resection. Material and methods. In the Burnazyan Federal Medical Biophysical Center that method was used in two cases: metastasises of bladder cancer in one case and of colorectal cancer in second case. Patients were males aged 57 and 64. Measuring the amount of future remaining liver volume was carried out with the CT-volumetry. Portal vein embolization of the right branch was carried out by transhepatic ipsilateral access using polyvinyl alcohol particles and occluder AVP II. Results. As a result in both cases the gain (9 and 24%), sufficient for performance of a resection, of the remaining liver volume was noted; the progression of the tumor process and periop-erative complications were not observed. Conclusion. Distal and proximal preoperative portal vein embolization is an effective and promising method, allowing surgeons to increase the number of operable patients and reduce the risk of postoperative liver failure.

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Rehabilitation of walking disorders with a freezing in patients Parkinson disease: methods of outpatient correction

Year: 2013, volume 9 Issue: №4 Pages: 923-927
Heading: rehabilitative medicine Article type: Original article
Authors: Krivonos О.V., Smolentseva I.G., Amosova N.A., Gubaydullina R.F., Karpova О.V., Chupina L. P.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

The study aimed the effectiveness of rehabilitation approaches for patients with Parkinson disease with a freezing at an outpatient condition. Material and methods. The study included 26 patients with Parkinson disease (14 men and 12 women), average age was 54.1± 9.5 years, average disease duration — 7.8± 3.1 years, the stage of the disease by Hoehn and Yahr scale — 3, 1±0.8. The control group included 15 patients with Parkinson disease (9 men and 6 women), matched in age, duration and severity. All patients have got a stable antiparkinsonian therapy before and during the study. The experiment had been performed for 6 months. The rehabilitation program consisted of 10 sessions. In rehabilitation program there had been used a sensor treadmill and Nordic walking. Patients had been kept training the Nordic walking at home through the course of the study. The results show the effectiveness of rehabilitation for reducing the severity of a freezing, increasing the speed of walking, the increased of the length step, decreased the time for turning compared to the control group. The effect had been supported by home rehabilitation training for 3 and 6 months after the study. Besides, patients from the main group did not need the change of the antiparkinsonian therapy after the study comparing with the control group.

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Преимущества организации длительной когнитивной реабилитации при болезни Паркинсона в специализированном клинико-диагностическом кабинете

Year: 2013, volume 9 Issue: №4 Pages: 917-922
Heading: rehabilitative medicine Article type: Original article
Authors: Krivonos О.V., Smolentseva I.G., Amosova N.A., Karpova O.V.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

The study aimed: to evaluate the advantages of the long-term of cognitive rehabilitation on the evidence of cognitive and affective disorders in Parkinson disease in a specialized clinical diagnostic room. Material and methods. The study included 37 patients with Parkinson disease (PD) — the study group, who had the long-term cognitive rehabilitation on the background of a standard drug therapy, and 28 patients in the control group, who had received only standard drug therapy. Assessment of cognitive function was carried out by neurologists, who had a course of thematic advanced training in the diagnosis and treatment of patients with extrapyramidal disorders, and who are working in a specialized clinical diagnostic room for patients with movement disorders. Results. Our results show the effectiveness of the long-term cognitive rehabilitation of Parkinson disease in specialized clinical diagnostic rooms. Whether the optimal duration and frequency of trainings, the duration of the course of the rehabilitation program remains unclear.

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