Saratov JOURNAL of Medical and Scientific Research

Kashkina E.I.

Saratov State Medical University, Department of Hospital Therapy of Therapeutic Faculty, Professor, Doctor of Medical Science

The treatment of gastroesophageal reflux disease in menopausal women suffering from diabetes mellitus type II

Year: 2016, volume 12 Issue: №4 Pages: 556-560
Heading: Internal Diseases Article type: Original article
Authors: Semikina Т.М., Kunitsyna M.A., Kashkina E.l.
Organization: Saratov State Medical University
Summary:

Purpose: to develop criteria for the selection of optimal tactics of supporting treatment of nonerosive gastroesophageal reflux disease with proton pump inhibitors in menopausal women suffering from diabetes mellitus type II. Material and Methods. 186 patients aged 45-59 who suffer from gastroesophageal reflux disease have been followed up, 46 of which suffer from diabetes mellitus type II as well. The climacteric syndrome's morbidity has been assessed in accordance with the modified menopause index; the level of glycated hemoglobin has been measured by the Abbott analyzer produced in the USA. Results. It is established that irrespective of the supporting treatment, the gastroesophageal reflux disease remittance was shorter in direct proportion with increase of the HbA1c level and the value of the modified menopause index in menopausal women suffering from diabetes mellitus type II. Conclusion. When the climacteric syndrome was mild or moderate, taking 20 mg Omeprazole once a day and "on demand" has comparable results, therefore this group of women prefer the "on demand" regimen as it lowers the risk of osteoporosis progression and further bone fracture. Taking 20 mg Omeprazole once a day, every other day, and "on demand" allows the disease remittance to prolong for a year and longer in less than 30% of women suffering from severe climacteric syndrome and having HbA1c>9.0%; however, this number may grow up to 70% of women in case they follow medical advice and reduce their carbohydrate input to 11 carbohydrate units and less.

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Ulcerative colitis: criteria and methods of prognosis of exacerbation

Year: 2014, volume 10 Issue: №3 Pages: 404-407
Heading: Internal Diseases Article type: Original article
Authors: Kashkina E.l., Fedosova M.A.
Organization: Saratov State Medical University
Summary:

Objective: research is devoted to the development of criteria and methods for prognosis of the next recurrence of exacerbation of ulcerative colitis (UC) after the patient discharged from hospital. Material and Methods: During a period of a year 38 patients with UC were supervised. The criteria used in the prognosis of recurrence included results of the evaluation of quality of life (SF-36 questionnaire), the analysis of the autonomic nervous system (coefficient Hildebrant and Kerdo index) and the level of stressful load procedure Holmes-Rage. Results. It has been established that the risk factors for recurrence include low quality of life on the scale of RP, SF and MH SF-36, the coefficient Hildebrant >5.6 units, Kerdo index 314 points. Conclusion: The obtained data have been processed by multivariate mathematical statistics and the obtained analytical expression allows to prognose the time of recurrence of ulcerative colitis.

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Expression of lectins in nonspecific ulcerative colitis

Year: 2012, volume 8 Issue: №4 Pages: 937-942
Heading: Internal Diseases Article type: Original article
Authors: Markova А.А., Kashkina E.I., Maslyakova G.N.
Organization: Saratov State Medical University
Summary:

Purpose: To analyze the expression of lectins in mucosa of a colon in patients with ulcerative colitis (UC), depending on the duration, severity, location and activity of the inflammatory process. Materials and methods: A total of 48 patients with ulcerative colitis and 15 healthy people have been examined. The expression of specific lectins has been determined in mucosa of colon. Results: in healthy patients the expression of the studied lectins has not been observed. In patients with ulcerative colitis there have been differences in the expression of the wheat ovaries lectin. Conclusion: In patients with ulcerative colitis the dependence of expression of the wheat ovaries lectin, WGA-isotropic to N-acetylglucosamine, on the severity and activity of the inflammatory process has been determined.

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Pancreatogenic diabetes mellitus: actual problems of pathogenesis and treatment

Year: 2012, volume 8 Issue: №3 Pages: 862-867
Heading: Endocrinology Article type: Review
Authors: Rebrov А.P., Kunitsyna М.А., Kashkina E.I., Arkhangelskaya Е.Е.
Organization: Saratov State Medical University
Summary:

We have presented the review of literature devoted to the problem of pancreatogenic diabetes mellitus. We have found up that prevalence of pancreatogenic diabetes mellitus needs to be adjusted. In analyzed literature the influence of localization of structural changes of pancreatic tissue on risk of diabetes mellitus development is studied insufficiently. In the result of our literature analysis we have detected that treatment of pancreatogenic diabetes mellitus up to date is not unified and is mostly descriptive, what indicates on necessity of further investigations in order to optimize and increase the efficacy of its treatment.

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Comparative assessment of efficacy of different methods of treatment of pancreatogenic diabetes mellitus in alcoholic and biliary forms of chronic pancreatitis

Year: 2012, volume 8 Issue: №3 Pages: 859-862
Heading: Endocrinology Article type: Original article
Authors: Kunitsyna М.А., Kashkina E.I.
Organization: Saratov State Medical University
Summary:

Aim: the study was devoted to the analysis of efficacy of different methods of treatment of pancreatogenic diabetes mellitus (DM) in alcoholic and biliary forms of chronic pancreatitis (CP). Material and methods. We have observed 86 patients with CP and first diagnosed DM. The assessment of carbohydrate metabolism compensation via HbA1 с level was done using analyzer IMX «Abbot» (USA). Results. At the 1st step of DM treatment we recommended the lifestyle modification and usage of creon 30-60.000 units daily. At the 2d step of treatment if necessary we added glyclazide. Conclusion. We have detected that irrespective of duration of alcoholic form of CP in case of subsequent DM development the lifestyle modification together with replacement ferment therapy in 90% of cases were non-effective. In the result of the research it was established, in case of 3 and more relapses per year in alcoholic form of CPthe probability of achievement of target HbA1 с level in complex with lifestyle changes and replacement ferment therapy was twice low, in connection with that fact the indication of oral anti-diabetic agents became necessary.

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Features of clinical course and quality of life in patients with chronic pancreatitis and diabetes mellitus

Year: 2011, volume 7 Issue: №1 Pages: 087-091
Heading: Internal Diseases Article type: Original article
Authors: Kunitsyna М.А., Kashkina E.I.
Organization: Saratov State Medical University
Summary:

Clinical and life quality features of 183 patients with chronic pancreatitis and diabetes mellitus were studied. We have found that the incidence of exacerbations increased by 36,7% after the appearance of diabetes mellitus, the number of days of loss of ability to work increased by 27,8%, the quality of life decreased

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New data on alcoholic liver disease

Year: 2010, volume 6 Issue: №2 Pages: 317-322
Heading: Internal Diseases Article type: Review
Authors: A.A. Antonyan, E.I. Kashkina, R.V. Lyakisheva
Organization: Saratov State Medical University, Saratov Regional Clinical Hospital
Summary:

The review of recent data is presented in the article. it concerns pathogenesis, course, progressing of pathologic process in liver, methods of treatment of patients with alcoholic liver disease

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Disturbance Of Sleep-Wake Regimen As Prognosis Criterion Of Gastroesophageal Reflux Disease Exacerbation

Year: 2009, volume 5 Issue: №3 Pages: 355-357
Heading: Internal Diseases Article type: Original article
Authors: E.I. Kashkina, R.V. Lyakisheva
Organization: Saratov State Medical University
Summary:

The goal of the present research is to define correlation of disease exacerbation risk within the next month and sleep-wake regimen changes in patients with gastroesophageal reflux disease. 40 patients with remission have been examined three times a week to determine qualitative and quantitative indices of sleep characteristic. During the following month the dynamic examination of the mentioned group of patients has been carried out for the purpose of timely acute condition diagnostics. It has been revealed that disturbances of sleep indices, such as late falling asleep, long-term falling asleep, frequency of awakening and unpleasant dreams become unfavorable risk factors for the development of the next recurrence of gastroesophageal reflux disease during the nearest month, but the remission of this disease is significantly connected with falling asleep duration and awakening time.

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FEATURES OF CLINICAL COURSE OF GASTROESOPHAGEAL REFLUX DISEASE IN NEWLY RECRUITED WITH CONNECTIVE TISSUE UNDIFFERENTIATED DYSPLASIA SYNDROME

Year: 2008, volume 4 Issue: №4 Pages: 46-49
Heading: Internal Diseases Article type: Original article
Authors: S.V. Semenov, E.I. Kashkina
Organization: Saratov State Medical University, Saratov Military Medical Institute
Summary:

The presence of connective tissue undifferentiated dysplasia syndrome against a background of psychological stress at newly recruited can promote the risk of gastroesophageal reflux disease occurrence. To the utmost, correlation between the gastroesophageal reflux disease and such manifestations of connective tissue undifferentiated dysplasia syndrome as asthenic constitution, chest deformation, Gothic palate and hypermobility of joints was found

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Chronic Biliary Pancreatitis Clinical Course Interrelation with Quality of Life and Patients Dependance on Supporting Therapy Indices

Year: 2009, volume 5 Issue: №2 Pages: 203-207
Heading: Internal Diseases Article type: Original article
Authors: E.I. Khashkina, J.V. Listishenkova
Organization: Saratov State Medical University
Summary:

The analysis of clinical course influence on life quality and patients dependance on supporting therapy of chronic biliary dependent pancreatitis is represented. It has been determined that increase of life quality is in close correlation with exacerbation frequency, dyspepsia syndrome evidence and manifestations of exocrinous insufficiency of pancreas. Patients with chronic biliary dependent pancreatitis do not carry out doctor’s recommendations in appropriate manner.

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