Saratov JOURNAL of Medical and Scientific Research

Suvorova L.A.

State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency, the leading researcher, Doctor of Biological Sciences

Medical consequences of Chernobyl accident

Year: 2015, volume 11 Issue: №4 Pages: 637-644
Heading: Hygiene Article type: Original article
Authors: Galstyan I.A., Nadejina N.M., Suvorova L.A., Kashirina O.G., Nugis V.Ju.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

Aim: to study the long-term effects of acute radiation syndrome (ARS), developed at the victims of the Chernobyl accident. Material and Methods. 237 people were exposed during the accident, 134 of them were diagnosed with ARS. Dynamic observation implies a thorough annual examination in a hospital. Results. In the first 1.5-2 years after the ARS mean group indices of peripheral blood have returned to normal. However, many patients had transient expressed moderate cytopenias. Granulocytopenia, thrombocytopenia, lymphopenia and erythropenia were the most frequently observed things during the first 5 years after the accident. After 5 years their occurences lowered. In 11 patients the radiation cataract was detected. A threshold dose for its development is a dose of 3.2 Gy Long-term effects of local radiation lesions (LRL) range from mild skin figure smoothing to a distinct fibrous scarring, contractures, persistently recurrent late radiation ulcers. During all years of observation we found 8 solid tumors, including 2 thyroid cancers. 5 hematologic diseases were found. During 29 years 26 ARS survivors died of various causes. Conclusion. The health of ones with long-term ARS effects is determined by the evolution of the LRL effects on skin, radiation cataracts, hema-tological diseases and the accession of of various somatic diseases, not caused by radiation.

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Blood status in the long-term radiation syndrome

Year: 2013, volume 9 Issue: №4 Pages: 882-890
Heading: radiation medicine Article type: Original article
Authors: Galstyan I.A., Suvorova L.A., Nadejina N.M., Kozlova M.G., Nugis V.Yu.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

Aims: to reveal regularities of change of peripheral blood indicators in the long-term acute radiation syndrome (ARS) depending on its initial severity and existence of various somatic diseases. Material and methods. Clinical he-matologic materials from 114 patients in the long-term ARS (from 1,5 to more than 20 years after radiation accident), developed as a result of gamma beta exposure are presented. Results. In the period of the late radiation effect average values of peripheral blood are in physiological norm limits. However at some patients there are temporary superficial cytopenic conditions (thrombocytopenia — 22,7%, a leukopenia — 12,2%, a neutropenia — 13,1%, a lymphocytope-nia — 10,5%). Conclusion. As a result of a dynamic research it is revealed that in the remote terms of ARS (from 1,5 to more than 20 years after radiation) average group levels of erythrocytes, leukocytes, neutrophils and lymphocytes in blood are in limits of physiological norm. However in the individual analysis of a functional state of blood at a part of patients are noted not stable cytopenic states.

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